Cannabis use is associated with changes in psychological and functional well-being during young adulthood: evidence from self-reports and hair analyses.
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| Titel: | Cannabis use is associated with changes in psychological and functional well-being during young adulthood: evidence from self-reports and hair analyses. |
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| Autoren: | Johnson-Ferguson L; Jacobs Center for Productive Youth Development, https://ror.org/02crff812University of Zurich, Zurich, Switzerland.; Experimental Pharmacopsychology and Psychological Addiction Research, Department of Psychiatry, Psychotherapy, and Psychosomatics, https://ror.org/01462r250University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland., Loher M; Jacobs Center for Productive Youth Development, https://ror.org/02crff812University of Zurich, Zurich, Switzerland., Bechtiger L; Jacobs Center for Productive Youth Development, https://ror.org/02crff812University of Zurich, Zurich, Switzerland., Janousch C; Jacobs Center for Productive Youth Development, https://ror.org/02crff812University of Zurich, Zurich, Switzerland.; Experimental Pharmacopsychology and Psychological Addiction Research, Department of Psychiatry, Psychotherapy, and Psychosomatics, https://ror.org/01462r250University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland., Baumgartner MR; Center for Forensic Hair Analytics; Zurich Institute of Legal Medicine, University of Zurich, Zurich, Switzerland., Binz TM; Center for Forensic Hair Analytics; Zurich Institute of Legal Medicine, University of Zurich, Zurich, Switzerland., Ribeaud D; Jacobs Center for Productive Youth Development, https://ror.org/02crff812University of Zurich, Zurich, Switzerland., Eisner M; Jacobs Center for Productive Youth Development, https://ror.org/02crff812University of Zurich, Zurich, Switzerland.; Institute of Criminology, https://ror.org/013meh722University of Cambridge, Cambridge, UK., Quednow BB; Jacobs Center for Productive Youth Development, https://ror.org/02crff812University of Zurich, Zurich, Switzerland.; Experimental Pharmacopsychology and Psychological Addiction Research, Department of Psychiatry, Psychotherapy, and Psychosomatics, https://ror.org/01462r250University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland., Shanahan L; Jacobs Center for Productive Youth Development, https://ror.org/02crff812University of Zurich, Zurich, Switzerland.; Department of Psychology, University of Zurich, Zurich, Switzerland. |
| Quelle: | Psychological medicine [Psychol Med] 2025 Aug 26; Vol. 55, pp. e246. Date of Electronic Publication: 2025 Aug 26. |
| Publikationsart: | Journal Article |
| Sprache: | English |
| Info zur Zeitschrift: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 1254142 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-8978 (Electronic) Linking ISSN: 00332917 NLM ISO Abbreviation: Psychol Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Cambridge University Press Original Publication: London, British Medical Assn. |
| MeSH-Schlagworte: | Dronabinol*/adverse effects , Dronabinol*/analysis , Marijuana Use*/adverse effects , Marijuana Use*/psychology , Mental Disorders*/chemically induced , Psychological Well-Being*, Humans ; Young Adult ; Cannabis ; Hair Analysis ; Psychopathology ; Self Report |
| Abstract: | Background: Cannabis use in young adulthood is common, yet few studies have explored how it predicts changes in psychopathology and functional well-being in community samples. We assessed these links using both self-reported frequency of cannabis use and hair THC concentrations. Methods: Data came from a community sample of young adults ( N = 863) who reported cannabis use (weekly-to-daily use: n = 150) and provided hair samples at age 20 (cannabis detected: n = 110). Liquid chromatography-tandem mass spectrometry quantified delta-9-tetrahydrocannabinol (THC) and cannabinol (CBN) concentrations in hair. At ages 20 and 24, participants reported psychopathology (psychotic-like experiences, problematic substance use, internalizing symptoms, and aggression) and functional wellbeing (general well-being, delinquency, and not being in employment, education, or training). Multiple linear and logit regression models tested associations between six different continuous and dichotomous operationalizations of self-reported and objective cannabis exposure at age 20 and psychological and functional well-being at age 24, adjusting for sex, sociodemographic characteristics, and the outcomes measured at age 20. Results: Both self-reported frequency of cannabis use and hair THC concentrations predicted increases in psychotic-like experiences and internalizing symptoms, increased aggression, decreased general well-being, higher odds of not being in employment, training, or education, and more problematic substance use from age 20 to 24, with small effect sizes. Composite exposure scores derived from self-reports and hair data were not more informative than either source alone. Conclusions: Frequent cannabis use predicted adverse changes in psychopathological outcomes from ages 20 to 24, regardless of how it was assessed. |
| References: | Psychol Med. 2021 Mar;51(4):617-622. (PMID: 31839011) Early Interv Psychiatry. 2015 Jun;9(3):207-10. (PMID: 24274357) JAMA Psychiatry. 2016 Apr;73(4):388-95. (PMID: 26886046) Assessment. 2019 Oct;26(7):1234-1245. (PMID: 28758417) Addiction. 2022 Feb;117(2):284-298. (PMID: 34264545) Front Hum Neurosci. 2022 Nov 11;16:951204. (PMID: 36438638) JAMA Psychiatry. 2019 Apr 1;76(4):426-434. (PMID: 30758486) J Am Acad Child Adolesc Psychiatry. 2023 Jul;62(7):791-804. (PMID: 36731790) Drug Alcohol Rev. 2017 Mar;36(2):220-226. (PMID: 27296783) Acta Paediatr. 2015 Feb;104(2):130-7. (PMID: 25377988) Eur Addict Res. 2025;31(1):60-74. (PMID: 39561726) Nat Rev Neurosci. 2020 May;21(5):247-263. (PMID: 32231315) Int J Drug Policy. 2022 Jul;105:103716. (PMID: 35613480) Psychopharmacology (Berl). 2002 Oct;164(1):61-70. (PMID: 12373420) Schizophr Bull. 2016 Sep;42(5):1262-9. (PMID: 26884547) Front Psychiatry. 2023 Feb 21;14:955626. (PMID: 36896345) J Dev Life Course Criminol. 2022;8(1):151-171. (PMID: 35223378) Front Psychiatry. 2020 Sep 23;11:591979. (PMID: 33173527) Lancet. 2007 Jul 28;370(9584):319-28. (PMID: 17662880) Soc Psychiatry Psychiatr Epidemiol. 2019 Aug;54(8):987-996. (PMID: 30929042) Psychopharmacology (Berl). 2024 Jun;241(6):1237-1244. (PMID: 38407636) Anal Methods. 2022 Nov 18;14(44):4583-4591. (PMID: 36317647) Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 May;6(5):536-544. (PMID: 33712378) Longit Life Course Stud. 2012;3(2):164-172. (PMID: 26473017) Psychoneuroendocrinology. 2023 Nov;157:106369. (PMID: 37639800) J Affect Disord. 2020 Jul 1;272:98-103. (PMID: 32379627) Addiction. 2019 Jun;114(6):1015-1023. (PMID: 30597667) Ann Epidemiol. 2005 May;15(5):381-9. (PMID: 15840552) Schizophr Bull. 2017 Jan;43(1):44-47. (PMID: 28053129) Australas Psychiatry. 2021 Feb;29(1):88-96. (PMID: 33174758) Aggress Violent Behav. 2024 Sep-Oct;78:. (PMID: 38828012) Psychol Med. 2022 Aug 25;:1-12. (PMID: 36004805) Perspect Psychol Sci. 2022 Jan;17(1):205-215. (PMID: 34213378) Sci Rep. 2015 Oct 07;5:14906. (PMID: 26443501) Lancet Psychiatry. 2014 Sep;1(4):286-93. (PMID: 26360862) Psychol Med. 2019 Jul;49(9):1574-1580. (PMID: 30176957) Chem Biodivers. 2007 Aug;4(8):1770-804. (PMID: 17712819) Health Educ Res. 2022 Mar 24;37(2):61-78. (PMID: 35311986) Addict Behav. 2023 Mar;138:107552. (PMID: 36413909) J Am Acad Child Adolesc Psychiatry. 2024 Nov;63(11):1084-1113. (PMID: 38552901) Cannabis Cannabinoid Res. 2017 Aug 01;2(1):217-223. (PMID: 29082319) J Youth Adolesc. 2021 Apr;50(4):663-673. (PMID: 33528705) Drug Alcohol Depend. 2021 Nov 1;228:109063. (PMID: 34601277) Ther Drug Monit. 2006 Apr;28(2):155-63. (PMID: 16628124) Schizophr Bull. 2016 Jan;42(1):34-44. (PMID: 26150674) Addiction. 2003 Nov;98(11):1493-504. (PMID: 14616175) Lancet Psychiatry. 2014 Dec;1(7):569-76. (PMID: 26361316) Psychol Med. 2014 Mar;44(4):797-810. (PMID: 23795762) Curr Pharm Des. 2012;18(32):4966-79. (PMID: 22716148) Am J Addict. 2017 Jun;26(4):335-342. (PMID: 28314070) Drug Alcohol Depend. 2001 Nov 1;64(3):319-27. (PMID: 11672946) J Am Acad Child Adolesc Psychiatry. 2022 Apr;61(4):533-543. (PMID: 34416291) Lancet Psychiatry. 2019 May;6(5):427-436. (PMID: 30902669) J Anal Toxicol. 2021 Aug 14;45(7):701-712. (PMID: 32986078) Eur Child Adolesc Psychiatry. 2025 Mar;34(3):1063-1074. (PMID: 39085493) Drug Test Anal. 2018 Apr;10(4):628-635. (PMID: 29441730) Child Psychiatry Hum Dev. 2022 Oct;53(5):1083-1096. (PMID: 34059956) Drug Test Anal. 2016 Jan;8(1):128-32. (PMID: 26097164) J Abnorm Child Psychol. 1991 Jun;19(3):285-300. (PMID: 1865046) Drug Alcohol Depend. 2021 Jul 1;224:108697. (PMID: 33930639) |
| Grant Information: | 10531C_189008 Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung |
| Contributed Indexing: | Keywords: THC; cannabis; functional well-being; hair; psychopathology; young adulthood |
| Substance Nomenclature: | 7J8897W37S (Dronabinol) |
| Entry Date(s): | Date Created: 20250826 Date Completed: 20250827 Latest Revision: 20250904 |
| Update Code: | 20250904 |
| PubMed Central ID: | PMC12404324 |
| DOI: | 10.1017/S003329172510144X |
| PMID: | 40856282 |
| Datenbank: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Background: Cannabis use in young adulthood is common, yet few studies have explored how it predicts changes in psychopathology and functional well-being in community samples. We assessed these links using both self-reported frequency of cannabis use and hair THC concentrations.<br />Methods: Data came from a community sample of young adults ( N = 863) who reported cannabis use (weekly-to-daily use: n = 150) and provided hair samples at age 20 (cannabis detected: n = 110). Liquid chromatography-tandem mass spectrometry quantified delta-9-tetrahydrocannabinol (THC) and cannabinol (CBN) concentrations in hair. At ages 20 and 24, participants reported psychopathology (psychotic-like experiences, problematic substance use, internalizing symptoms, and aggression) and functional wellbeing (general well-being, delinquency, and not being in employment, education, or training). Multiple linear and logit regression models tested associations between six different continuous and dichotomous operationalizations of self-reported and objective cannabis exposure at age 20 and psychological and functional well-being at age 24, adjusting for sex, sociodemographic characteristics, and the outcomes measured at age 20.<br />Results: Both self-reported frequency of cannabis use and hair THC concentrations predicted increases in psychotic-like experiences and internalizing symptoms, increased aggression, decreased general well-being, higher odds of not being in employment, training, or education, and more problematic substance use from age 20 to 24, with small effect sizes. Composite exposure scores derived from self-reports and hair data were not more informative than either source alone.<br />Conclusions: Frequent cannabis use predicted adverse changes in psychopathological outcomes from ages 20 to 24, regardless of how it was assessed. |
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| ISSN: | 1469-8978 |
| DOI: | 10.1017/S003329172510144X |