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The relationship between racial discrimination and white matter among Black older adults.

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Název: The relationship between racial discrimination and white matter among Black older adults.
Autoři: Palms JD; Department of Psychology, University of Michigan, 1004 East Hall, 530 Church St, Ann Arbor, MI 48109, United States. Electronic address: jdpalms@umich.edu., Lee JH; Department of Human Development and Community Health, Montana State University, 223 Herrick Hall, Bozeman, MT 59715, United States., Morris EP; Department of Psychology, University of Michigan, 1004 East Hall, 530 Church St, Ann Arbor, MI 48109, United States., Sol K; Comprehensive Center for Brain Health, Department of Neurology, Miller School of Medicine, University of Miami., Walters ME; Department of Psychology, University of Michigan, 1004 East Hall, 530 Church St, Ann Arbor, MI 48109, United States., Scambray KA; Department of Psychology, University of Michigan, 1004 East Hall, 530 Church St, Ann Arbor, MI 48109, United States., Morales CD; Department of Neurology, Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 710 West 168th St, New York, NY 10032, United States., Alshikho MJ; Department of Neurology, Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 710 West 168th St, New York, NY 10032, United States., Lao PJ; Department of Neurology, Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 710 West 168th St, New York, NY 10032, United States., Manly JJ; Department of Neurology, Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 710 West 168th St, New York, NY 10032, United States., Brickman AM; Department of Neurology, Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 710 West 168th St, New York, NY 10032, United States., Zahodne LB; Department of Psychology, University of Michigan, 1004 East Hall, 530 Church St, Ann Arbor, MI 48109, United States.
Zdroj: Neurobiology of aging [Neurobiol Aging] 2025 Dec; Vol. 156, pp. 63-72. Date of Electronic Publication: 2025 Jul 30.
Způsob vydávání: Journal Article
Jazyk: English
Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 8100437 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-1497 (Electronic) Linking ISSN: 01974580 NLM ISO Abbreviation: Neurobiol Aging Subsets: MEDLINE
Imprint Name(s): Publication: New York : Elsevier
Original Publication: Fayetteville, N.Y. : Ankho International.
Výrazy ze slovníku MeSH: White Matter*/pathology , White Matter*/diagnostic imaging , Racism*/psychology , Black or African American*/psychology , Cognitive Aging*/psychology , Aging*/psychology , Aging*/pathology, Humans ; Male ; Female ; Aged ; Diffusion Tensor Imaging ; Middle Aged ; Aged, 80 and over ; Anisotropy ; Stress, Psychological ; Brain/pathology
Abstrakt: Black older adults experience worse brain and cognitive aging than White older adults, on average. Racially patterned psychosocial stressors may contribute to these disparities. Maintaining white matter health is important for cognitive aging, particularly among Black older adults, and it is uniquely vulnerable to stress. Examining associations between racial discrimination and white matter may elucidate mechanisms of disparities. A sample of Black older adults in the Washington Heights-Inwood Columbia Aging project were included (N = 217). Everyday and major life discrimination were self-reported on well-validated scales. Diffusion tensor imaging quantified white matter fractional anisotropy (FA). Multivariable regressions revealed more major life discrimination was associated with lower FA in the cingulum cingulate gyrus, forceps major, forceps minor, and inferior fronto-occipital fasciculus but greater FA in the superior longitudinal fasciculus temporal projection. Everyday discrimination was not associated with FA. Findings suggest that institutional racism may have a stronger effect on white matter tracts corresponding to cognitive and emotional/affective processing than interpersonal racism. White matter health may be a mechanism through which racially patterned stressors contribute to disparities in brain and cognitive aging.
(Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.)
Contributed Indexing: Keywords: Brain health; Diffusion tensor imaging (DTI); Fractional anisotropy (FA); Psychosocial stress; Racism
Entry Date(s): Date Created: 20250821 Date Completed: 20251018 Latest Revision: 20251121
Update Code: 20251121
DOI: 10.1016/j.neurobiolaging.2025.07.017
PMID: 40839940
Databáze: MEDLINE
Popis
Abstrakt:Black older adults experience worse brain and cognitive aging than White older adults, on average. Racially patterned psychosocial stressors may contribute to these disparities. Maintaining white matter health is important for cognitive aging, particularly among Black older adults, and it is uniquely vulnerable to stress. Examining associations between racial discrimination and white matter may elucidate mechanisms of disparities. A sample of Black older adults in the Washington Heights-Inwood Columbia Aging project were included (N = 217). Everyday and major life discrimination were self-reported on well-validated scales. Diffusion tensor imaging quantified white matter fractional anisotropy (FA). Multivariable regressions revealed more major life discrimination was associated with lower FA in the cingulum cingulate gyrus, forceps major, forceps minor, and inferior fronto-occipital fasciculus but greater FA in the superior longitudinal fasciculus temporal projection. Everyday discrimination was not associated with FA. Findings suggest that institutional racism may have a stronger effect on white matter tracts corresponding to cognitive and emotional/affective processing than interpersonal racism. White matter health may be a mechanism through which racially patterned stressors contribute to disparities in brain and cognitive aging.<br /> (Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.)
ISSN:1558-1497
DOI:10.1016/j.neurobiolaging.2025.07.017