Comparing Pediatric Dermatology Research Funded by the US National Institutes of Health (NIH) With the US Skin Disease Burden in Patients Under 20 Years Old.
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| Názov: | Comparing Pediatric Dermatology Research Funded by the US National Institutes of Health (NIH) With the US Skin Disease Burden in Patients Under 20 Years Old. |
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| Autori: | Mackenzie E; Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA., Amancharla N; Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA., Casagrande S; Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA., Ayyaz W; Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA., Tchack M; Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.; Rao Dermatology, New York, New York, USA.; Center for Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, New Jersey, USA., Musolff N; Rao Dermatology, New York, New York, USA., Rao B; Rao Dermatology, New York, New York, USA.; Center for Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, New Jersey, USA.; Department of Dermatology, Weill Cornell Medicine, New York, New York, USA. |
| Zdroj: | Pediatric dermatology [Pediatr Dermatol] 2025 Sep-Oct; Vol. 42 (5), pp. 993-997. Date of Electronic Publication: 2025 Aug 17. |
| Spôsob vydávania: | Journal Article; Comparative Study |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Wiley Country of Publication: United States NLM ID: 8406799 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1470 (Electronic) Linking ISSN: 07368046 NLM ISO Abbreviation: Pediatr Dermatol Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2010->: Hoboken, NJ : Wiley Original Publication: [Boston, MA] : Blackwell Scientific Publications, [1983- |
| Výrazy zo slovníka MeSH: | National Institutes of Health (U.S.)*/economics , Skin Diseases*/economics , Skin Diseases*/epidemiology , Biomedical Research*/economics , Dermatology*/economics , Cost of Illness* , Research Support as Topic*/statistics & numerical data , Research Support as Topic*/economics, United States ; Humans ; Cross-Sectional Studies ; Child ; Adolescent ; Child, Preschool ; Disability-Adjusted Life Years ; Young Adult ; Infant ; Male |
| Abstrakt: | Background: Disease burden, measured by disability-adjusted life years (DALYs), is a helpful metric to guide research funding priorities. Pediatric dermatologic conditions significantly contribute to DALYs, yet it is unclear whether NIH funding reflects this burden. Objectives: To compare NIH-funded dermatology research with the most burdensome skin diseases in the United States for patients under 20 years old, as measured by DALYs, and to identify mismatches between funding and disease burden. Methods: A cross-sectional analysis was independently performed by two researchers who matched projects from the 2024 to 2025 NIH Research Portfolio Online Reporting Tools with 10 pediatric dermatology skin conditions and their respective DALYs from the Global Burden of Disease (GBD) 2021 study. NIH-funded research projects were categorized by condition and pediatric focus, and funding allocation was compared to DALYs to evaluate alignment. Results: The NIH supported 307 grants totaling $388 million across the 10 skin conditions. Atopic dermatitis received the most funding ($62.99 million), with 47.9% of grants pediatric-focused. Viral skin diseases, despite being second in burden, received only $2.35 million and 0 pediatric grants. Most conditions had fewer than 15% pediatric-focused grants. Conclusions: There is a persistent mismatch between NIH funding and the burden of pediatric skin disease, both in overall funding and in the proportion of research focused on pediatric populations. Increased investment in high-burden, underfunded conditions, particularly those lacking pediatric-specific research, is essential. (© 2025 The Author(s). Pediatric Dermatology published by Wiley Periodicals LLC.) |
| References: | Arch Dermatol Res. 2024 Jul 23;316(7):487. (PMID: 39042295) J Am Acad Dermatol. 2015 Sep;73(3):383-91.e1. (PMID: 26051697) Bull World Health Organ. 1994;72(3):429-45. (PMID: 8062401) Pharmaceutics. 2021 Jul 11;13(7):. (PMID: 34371756) Lancet. 2024 May 18;403(10440):1958-1959. (PMID: 38642567) Curr Dermatol Rep. 2017 Sep;6(3):204-210. (PMID: 29226027) JAMA Pediatr. 2021 Dec 1;175(12):1236-1243. (PMID: 34515752) Br J Dermatol. 2016 Apr;174(4):853-61. (PMID: 26686685) Pediatr Dermatol. 2025 Sep-Oct;42(5):993-997. (PMID: 40820233) N Engl J Med. 1999 Jun 17;340(24):1881-7. (PMID: 10369852) PLoS One. 2011 Feb 24;6(2):e16837. (PMID: 21383981) |
| Entry Date(s): | Date Created: 20250817 Date Completed: 20250924 Latest Revision: 20250926 |
| Update Code: | 20250926 |
| PubMed Central ID: | PMC12459415 |
| DOI: | 10.1111/pde.70007 |
| PMID: | 40820233 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Background: Disease burden, measured by disability-adjusted life years (DALYs), is a helpful metric to guide research funding priorities. Pediatric dermatologic conditions significantly contribute to DALYs, yet it is unclear whether NIH funding reflects this burden.<br />Objectives: To compare NIH-funded dermatology research with the most burdensome skin diseases in the United States for patients under 20 years old, as measured by DALYs, and to identify mismatches between funding and disease burden.<br />Methods: A cross-sectional analysis was independently performed by two researchers who matched projects from the 2024 to 2025 NIH Research Portfolio Online Reporting Tools with 10 pediatric dermatology skin conditions and their respective DALYs from the Global Burden of Disease (GBD) 2021 study. NIH-funded research projects were categorized by condition and pediatric focus, and funding allocation was compared to DALYs to evaluate alignment.<br />Results: The NIH supported 307 grants totaling $388 million across the 10 skin conditions. Atopic dermatitis received the most funding ($62.99 million), with 47.9% of grants pediatric-focused. Viral skin diseases, despite being second in burden, received only $2.35 million and 0 pediatric grants. Most conditions had fewer than 15% pediatric-focused grants.<br />Conclusions: There is a persistent mismatch between NIH funding and the burden of pediatric skin disease, both in overall funding and in the proportion of research focused on pediatric populations. Increased investment in high-burden, underfunded conditions, particularly those lacking pediatric-specific research, is essential.<br /> (© 2025 The Author(s). Pediatric Dermatology published by Wiley Periodicals LLC.) |
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| ISSN: | 1525-1470 |
| DOI: | 10.1111/pde.70007 |