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Decoding Noncoding RNAs: Mastering Bone Morphogenetic Protein Signaling and Crosstalk Pathways for Breakthroughs in Periodontal Regeneration.

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Title: Decoding Noncoding RNAs: Mastering Bone Morphogenetic Protein Signaling and Crosstalk Pathways for Breakthroughs in Periodontal Regeneration.
Authors: Ghanati H; Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran., Motamedi S; Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Fallahpour S; Faculty of Biological Sciences, Department of Biology, Islamic Azad University, Esfahan, Iran., Bayat A; Faculty of Dentistry, Arak University of Medical Sciences, Arak, Iran., Maddahi M; Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, University of Health Sciences, Istanbul, Turkey., Kazemi P; Faculty of Dentistry, Ilam University of Medical Science, Ilam, Iran., Aghakouchakzadeh A; Department of Oral and Maxillofacial Pathology, School of Dentistry, Alborz University of Medical Sciences, Karaj, Iran., Rezaee A; Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran., Hakimy S; Faculty of Dentistry, Department of Prosthodontics, Istanbul Medipol University, Istanbul, Türkiye., Pirouzan M; Alumni of Dental School, Alborz University of Medical Science, Karaj, Iran., Rostami M; Faculty of Dentistry, Tehran University of Medical Science, Tehran, Iran., Dibazar ZE; Faculty of Dentistry, Tabriz University of Medical Science, Tabriz, Iran.; Faculty of Dentistry, Birjand University of Medical Science, Birjand, Iran.
Source: DNA and cell biology [DNA Cell Biol] 2025 Sep; Vol. 44 (9), pp. 486-501. Date of Electronic Publication: 2025 Aug 11.
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 9004522 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7430 (Electronic) Linking ISSN: 10445498 NLM ISO Abbreviation: DNA Cell Biol Subsets: MEDLINE
Imprint Name(s): Publication: Larchmont, NY : Mary Ann Liebert
Original Publication: [New York, NY] : Mary Ann Liebert, [c1990-
MeSH Terms: Regeneration*/genetics , RNA, Untranslated*/genetics , RNA, Untranslated*/metabolism , Bone Morphogenetic Proteins*/metabolism , Bone Morphogenetic Proteins*/genetics , Periodontium*/physiology, Humans ; Signal Transduction ; Periodontal Ligament/physiology ; Periodontal Ligament/metabolism ; Animals ; Tissue Engineering
Abstract: Regenerating periodontal tissues remains a significant hurdle in regenerative dentistry, requiring meticulous coordination of cellular and molecular mechanisms. Noncoding RNAs (ncRNAs), including microRNAs, long ncRNAs, and circular RNAs, are emerging as essential modulators of bone morphogenetic protein (BMP) signaling pathways, which are vital for processes such as osteogenesis, cementum formation, and periodontal ligament (PDL) repair. This review delves into the pivotal role of ncRNAs in influencing BMP signaling while briefly addressing their interaction with other critical pathways, such as transforming growth factor-beta, Activin, Wnt, Notch, mitogen-activated protein kinase, and PI3K. These ncRNAs act as dynamic regulators, fine-tuning BMP signaling to facilitate tissue differentiation, modulate inflammatory responses, and enhance extracellular matrix remodeling-key elements for addressing the complexity of periodontal tissue regeneration. By compiling the latest advancements, this review sheds light on the potential of ncRNAs as therapeutic targets, emphasizing their ability to refine BMP signaling for greater precision in tissue engineering. Moreover, the integration of ncRNA insights with advanced biomaterials and engineering solutions offers a promising direction for reconstructing the intricate bone-PDL-cementum complex. Framing ncRNAs as a central innovation in regenerative therapy, this review underscores their transformative potential in addressing the multifactorial challenges of periodontal repair and restoration.
Contributed Indexing: Keywords: bone morphogenetic proteins; crosstalk; mesenchymal stem cells; ncRNAs; periodontal tissue regeneration
Substance Nomenclature: 0 (RNA, Untranslated)
0 (Bone Morphogenetic Proteins)
Entry Date(s): Date Created: 20250811 Date Completed: 20250916 Latest Revision: 20250916
Update Code: 20250916
DOI: 10.1177/10445498251362766
PMID: 40788828
Database: MEDLINE
Description
Abstract:Regenerating periodontal tissues remains a significant hurdle in regenerative dentistry, requiring meticulous coordination of cellular and molecular mechanisms. Noncoding RNAs (ncRNAs), including microRNAs, long ncRNAs, and circular RNAs, are emerging as essential modulators of bone morphogenetic protein (BMP) signaling pathways, which are vital for processes such as osteogenesis, cementum formation, and periodontal ligament (PDL) repair. This review delves into the pivotal role of ncRNAs in influencing BMP signaling while briefly addressing their interaction with other critical pathways, such as transforming growth factor-beta, Activin, Wnt, Notch, mitogen-activated protein kinase, and PI3K. These ncRNAs act as dynamic regulators, fine-tuning BMP signaling to facilitate tissue differentiation, modulate inflammatory responses, and enhance extracellular matrix remodeling-key elements for addressing the complexity of periodontal tissue regeneration. By compiling the latest advancements, this review sheds light on the potential of ncRNAs as therapeutic targets, emphasizing their ability to refine BMP signaling for greater precision in tissue engineering. Moreover, the integration of ncRNA insights with advanced biomaterials and engineering solutions offers a promising direction for reconstructing the intricate bone-PDL-cementum complex. Framing ncRNAs as a central innovation in regenerative therapy, this review underscores their transformative potential in addressing the multifactorial challenges of periodontal repair and restoration.
ISSN:1557-7430
DOI:10.1177/10445498251362766