Social interaction in mice suppresses breast cancer progression via a corticoamygdala neural circuit.
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| Název: | Social interaction in mice suppresses breast cancer progression via a corticoamygdala neural circuit. |
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| Autoři: | Wen HZ; Department of Neurobiology, Chongqing Key Laboratory of Brain Development and Cognitive Science, Army Medical University, Chongqing 400038, China., Xiong SY; Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing 400038, China., Lou YX; Department of Neurobiology, Chongqing Key Laboratory of Brain Development and Cognitive Science, Army Medical University, Chongqing 400038, China., Yang SZ; Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing 400038, China., Sun L; Southwest Hospital, Army Medical University, Chongqing 400038, China., Yi YL; Experimental Center of Basic Medicine, Chongqing Key Laboratory of Brain Development and Cognitive Science, Army Medical University, Chongqing 400038, China., Tang BQ; Experimental Center of Basic Medicine, Chongqing Key Laboratory of Brain Development and Cognitive Science, Army Medical University, Chongqing 400038, China., Shu Q; Experimental Center of Basic Medicine, Chongqing Key Laboratory of Brain Development and Cognitive Science, Army Medical University, Chongqing 400038, China., Wang ZQ; Department of Neurobiology, Chongqing Key Laboratory of Brain Development and Cognitive Science, Army Medical University, Chongqing 400038, China., Yan XJ; Department of Biochemistry and Molecular Biology, Army Medical University, Chongqing 400038, China., Wu YR; Department of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing 400037, China., Chen PH; Department of Neurobiology, Chongqing Key Laboratory of Brain Development and Cognitive Science, Army Medical University, Chongqing 400038, China., Qi XW; Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing 400038, China., Zhang Y; Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing 400038, China. Electronic address: yzhang@tmmu.edu.cn., Dai LM; Department of Gynecology and Obstetrics, Southwest Hospital, Army Medical University, Chongqing 400038, China. Electronic address: dailimeng@tmmu.edu.cn., Xiong Y; Department of Neurobiology, Chongqing Key Laboratory of Brain Development and Cognitive Science, Army Medical University, Chongqing 400038, China. Electronic address: yxiong@tmmu.edu.cn., Wu GY; Experimental Center of Basic Medicine, Chongqing Key Laboratory of Brain Development and Cognitive Science, Army Medical University, Chongqing 400038, China. Electronic address: wgy009@tmmu.edu.cn. |
| Zdroj: | Neuron [Neuron] 2025 Oct 15; Vol. 113 (20), pp. 3374-3389.e9. Date of Electronic Publication: 2025 Aug 01. |
| Způsob vydávání: | Journal Article |
| Jazyk: | English |
| Informace o časopise: | Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Cambridge, Mass. : Cell Press, c1988- |
| Výrazy ze slovníku MeSH: | Social Interaction* , Gyrus Cinguli*/physiology , Basolateral Nuclear Complex*/physiology , Breast Neoplasms*/psychology , Breast Neoplasms*/pathology , Nerve Net*, Animals ; Mice ; Female ; Disease Progression ; Neural Pathways/physiology ; Mice, Inbred C57BL ; Amygdala |
| Abstrakt: | Competing Interests: Declaration of interests The authors declare no competing interests. Social behaviors are vital for all mammalian species. Clinical observations and epidemiological studies have demonstrated that social interaction (SI) may slow cancer progression and improve patient outcomes. However, the underlying neural mechanisms remain unknown. Here, we found that SI in mouse models suppresses tumor growth through activating glutamatergic inputs from the anterior cingulate cortex (ACC Glu ) to the basolateral amygdala (BLA), inhibiting intratumoral sympathetic nerve activity. Chemogenetic inhibition of the SI-activated ACC Glu neurons and ACC Glu →BLA Glu circuits abolished anxiolytic and antitumor effects of SI. Artificial reactivation of these neurons and circuits could mimic the anxiolytic and antitumor effects of SI. Manipulating the ACC Glu →BLA Glu circuits to regulate intratumoral sympathetic activity and norepinephrine (NE) release affected tumor progression by modulating antitumor immunity. Collectively, our study shows that SI activates the corticoamygdala neural circuit, which suppresses cancer progression, offering potential insights into the clinical application of social support in cancer treatment. (Copyright © 2025 Elsevier Inc. All rights reserved.) |
| Contributed Indexing: | Keywords: brain; breast cancer; cancer neuroscience; neural circuit; social interaction; tumor microenvironment |
| Entry Date(s): | Date Created: 20250802 Date Completed: 20251016 Latest Revision: 20251017 |
| Update Code: | 20251018 |
| DOI: | 10.1016/j.neuron.2025.07.002 |
| PMID: | 40752486 |
| Databáze: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declaration of interests The authors declare no competing interests.<br />Social behaviors are vital for all mammalian species. Clinical observations and epidemiological studies have demonstrated that social interaction (SI) may slow cancer progression and improve patient outcomes. However, the underlying neural mechanisms remain unknown. Here, we found that SI in mouse models suppresses tumor growth through activating glutamatergic inputs from the anterior cingulate cortex (ACC <sup>Glu</sup> ) to the basolateral amygdala (BLA), inhibiting intratumoral sympathetic nerve activity. Chemogenetic inhibition of the SI-activated ACC <sup>Glu</sup> neurons and ACC <sup>Glu</sup> →BLA <sup>Glu</sup> circuits abolished anxiolytic and antitumor effects of SI. Artificial reactivation of these neurons and circuits could mimic the anxiolytic and antitumor effects of SI. Manipulating the ACC <sup>Glu</sup> →BLA <sup>Glu</sup> circuits to regulate intratumoral sympathetic activity and norepinephrine (NE) release affected tumor progression by modulating antitumor immunity. Collectively, our study shows that SI activates the corticoamygdala neural circuit, which suppresses cancer progression, offering potential insights into the clinical application of social support in cancer treatment.<br /> (Copyright © 2025 Elsevier Inc. All rights reserved.) |
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| ISSN: | 1097-4199 |
| DOI: | 10.1016/j.neuron.2025.07.002 |