Impact of timing and breastfeeding on postpartum breast cancer diagnostic patterns and outcomes.
Uložené v:
| Názov: | Impact of timing and breastfeeding on postpartum breast cancer diagnostic patterns and outcomes. |
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| Autori: | Klebaner D; Department of Radiation Oncology, Stanford Cancer Institute, Stanford, CA, USA., Park N; Department of Radiation Oncology, Stanford Cancer Institute, Stanford, CA, USA., Stone K; Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA., Riaz F; Division of Medical Oncology, Department of Medicine, Stanford Cancer Institute, Stanford, CA, USA., Crowe S; Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA., Telli M; Division of Medical Oncology, Department of Medicine, Stanford Cancer Institute, Stanford, CA, USA., Marquez C; Department of Radiation Oncology, Stanford Cancer Institute, Stanford, CA, USA., Horst K; Department of Radiation Oncology, Stanford Cancer Institute, Stanford, CA, USA. kateh@stanford.edu. |
| Zdroj: | Breast cancer research and treatment [Breast Cancer Res Treat] 2025 Nov; Vol. 214 (1), pp. 79-86. Date of Electronic Publication: 2025 Jul 30. |
| Spôsob vydávania: | Journal Article |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE |
| Imprint Name(s): | Publication: Dordrecht : Kluwer Academic Original Publication: The Hague ; Boston : M. Nijhoff, c1981- |
| Výrazy zo slovníka MeSH: | Breast Neoplasms*/diagnosis , Breast Neoplasms*/mortality , Breast Neoplasms*/epidemiology , Breast Neoplasms*/pathology , Breast Feeding* , Postpartum Period*, Humans ; Female ; Adult ; Prognosis ; Middle Aged ; Delayed Diagnosis ; Time Factors ; Neoplasm Staging ; Kaplan-Meier Estimate |
| Abstrakt: | Competing Interests: Declarations. Conflict of interest: KS has received research funding from Lumicell. The remaining authors have no additional disclosures. Ethical approval: This was an observational studied and approved by our Institutional Review Board, Protocol 35536. Purpose: Postpartum breast cancers (PPBC) have a worse prognosis than other breast cancers, but the impact of timing postpartum (PP) and concurrent breastfeeding (BF) on diagnostic patterns and outcomes remains unclear. Methods: We analyzed 161 PPBC patients diagnosed from 2002 to 2014, hypothesizing that diagnosis < 2 years PP (vs 2-5 years) and concurrent BF (vs not BF) at diagnosis would be associated with delayed diagnosis. We compared 2-year PP patients (N = 60) and 2-5 year PP patients (N = 101), and subsequently, patients who were (n = 36) and were not (n = 24) BF at diagnosis among the 2-year PP group with respect to clinicopathologic characteristics, breastfeeding details, diagnostic patterns, and disease outcomes. Differences were evaluated using chi-square and Mann-Whitney tests. Kaplan-Meier analysis assessed overall survival (OS) and distant disease-free survival (DDFS). Results: Median follow-up was 54 months. Patients in the 2-year PP group were more likely to be BF at diagnosis (60% vs 7%, p < 0.001), and have their symptoms attributed to lactational change (37 vs 9%, p < 0.001). They were also diagnosed at a higher stage (43 vs 24% Stage III/IV, p = 0.01), had worse 5-year OS (79% vs 97%, p < 0.001), and DDFS (74% vs 93%, p = 0.003) compared to 2-5 year PP patients. Among 2-year PP patients, patients BF at diagnosis were more likely to be diagnosed with mastitis preceding diagnosis (31% vs 4%, p = 0.03), more often had their symptoms attributed to lactational change (58% vs 4%), trended toward higher stage at diagnosis (53 vs 29% Stage III/IV, p = 0.1), had significantly worse 5-year DDFS (62% vs 91%, p = 0.032), and trended toward worse OS (74% vs 86%, p = 0.08) compared to those not BF. Conclusions: Our findings suggest that early PPBC and BF at diagnosis are associated with diagnostic delay and higher stage at diagnosis, which may have implications for prognosis. (© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| Contributed Indexing: | Keywords: Breast neoplasms; Delayed diagnosis; Lactation; Postpartum period |
| Entry Date(s): | Date Created: 20250731 Date Completed: 20250830 Latest Revision: 20250830 |
| Update Code: | 20250903 |
| DOI: | 10.1007/s10549-025-07796-2 |
| PMID: | 40739382 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declarations. Conflict of interest: KS has received research funding from Lumicell. The remaining authors have no additional disclosures. Ethical approval: This was an observational studied and approved by our Institutional Review Board, Protocol 35536.<br />Purpose: Postpartum breast cancers (PPBC) have a worse prognosis than other breast cancers, but the impact of timing postpartum (PP) and concurrent breastfeeding (BF) on diagnostic patterns and outcomes remains unclear.<br />Methods: We analyzed 161 PPBC patients diagnosed from 2002 to 2014, hypothesizing that diagnosis < 2 years PP (vs 2-5 years) and concurrent BF (vs not BF) at diagnosis would be associated with delayed diagnosis. We compared 2-year PP patients (N = 60) and 2-5 year PP patients (N = 101), and subsequently, patients who were (n = 36) and were not (n = 24) BF at diagnosis among the 2-year PP group with respect to clinicopathologic characteristics, breastfeeding details, diagnostic patterns, and disease outcomes. Differences were evaluated using chi-square and Mann-Whitney tests. Kaplan-Meier analysis assessed overall survival (OS) and distant disease-free survival (DDFS).<br />Results: Median follow-up was 54 months. Patients in the 2-year PP group were more likely to be BF at diagnosis (60% vs 7%, p < 0.001), and have their symptoms attributed to lactational change (37 vs 9%, p < 0.001). They were also diagnosed at a higher stage (43 vs 24% Stage III/IV, p = 0.01), had worse 5-year OS (79% vs 97%, p < 0.001), and DDFS (74% vs 93%, p = 0.003) compared to 2-5 year PP patients. Among 2-year PP patients, patients BF at diagnosis were more likely to be diagnosed with mastitis preceding diagnosis (31% vs 4%, p = 0.03), more often had their symptoms attributed to lactational change (58% vs 4%), trended toward higher stage at diagnosis (53 vs 29% Stage III/IV, p = 0.1), had significantly worse 5-year DDFS (62% vs 91%, p = 0.032), and trended toward worse OS (74% vs 86%, p = 0.08) compared to those not BF.<br />Conclusions: Our findings suggest that early PPBC and BF at diagnosis are associated with diagnostic delay and higher stage at diagnosis, which may have implications for prognosis.<br /> (© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| ISSN: | 1573-7217 |
| DOI: | 10.1007/s10549-025-07796-2 |