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The Reciprocal Relationship Between Cell Adhesion Molecules and Reactive Oxygen Species.

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Názov: The Reciprocal Relationship Between Cell Adhesion Molecules and Reactive Oxygen Species.
Autori: Al-Hadi M; School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia., Nikonenko AG; Department of Cytology, Bogomoletz Institute of Physiology, 01024 Kyiv, Ukraine., Sytnyk V; School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia.
Zdroj: Cells [Cells] 2025 Jul 17; Vol. 14 (14). Date of Electronic Publication: 2025 Jul 17.
Spôsob vydávania: Journal Article; Review
Jazyk: English
Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
Imprint Name(s): Original Publication: Basel, Switzerland : MDPI
Výrazy zo slovníka MeSH: Reactive Oxygen Species*/metabolism , Cell Adhesion Molecules*/metabolism, Humans ; Animals ; Cell Adhesion ; Signal Transduction
Abstrakt: Cell adhesion molecules (CAMs) are cell-surface-localized proteins mediating interactions of cells with other cells and the extracellular matrix. CAMs influence cell behavior and survival by inducing various intracellular signaling cascades that regulate diverse cellular processes including cytoskeleton remodeling and gene expression. Here, we review the evidence demonstrating that the levels, subcellular distribution, and binding affinities of CAMs of several major families including integrins, cadherins, immunoglobulin superfamily, and selectins are regulated by intracellularly generated or extracellular reactive oxygen species (ROS). Remarkably, CAMs themselves induce ROS production in response to binding to their ligands by activating lipoxygenases or NADPH oxidases or influencing ROS generation in mitochondria. CAM-dependent ROS production is essential for CAM-mediated cell adhesion and CAM-dependent intracellular signaling. Importantly, CAMs also protect cells from the ROS-induced cell death by stimulating the synthesis of antioxidants and suppressing the cell death signaling. A better understanding of the role ROS play in controlling CAM functions and mechanisms of this control may pave the way to modulating the functions of CAMs in various disorders associated with abnormal cell adhesion.
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Contributed Indexing: Keywords: cadherin; cell adhesion molecule; cell death; immunoglobulin superfamily; integrin; reactive oxygen species; selectin
Substance Nomenclature: 0 (Reactive Oxygen Species)
0 (Cell Adhesion Molecules)
Entry Date(s): Date Created: 20250725 Date Completed: 20250725 Latest Revision: 20250729
Update Code: 20250729
PubMed Central ID: PMC12293960
DOI: 10.3390/cells14141098
PMID: 40710351
Databáza: MEDLINE
Popis
Abstrakt:Cell adhesion molecules (CAMs) are cell-surface-localized proteins mediating interactions of cells with other cells and the extracellular matrix. CAMs influence cell behavior and survival by inducing various intracellular signaling cascades that regulate diverse cellular processes including cytoskeleton remodeling and gene expression. Here, we review the evidence demonstrating that the levels, subcellular distribution, and binding affinities of CAMs of several major families including integrins, cadherins, immunoglobulin superfamily, and selectins are regulated by intracellularly generated or extracellular reactive oxygen species (ROS). Remarkably, CAMs themselves induce ROS production in response to binding to their ligands by activating lipoxygenases or NADPH oxidases or influencing ROS generation in mitochondria. CAM-dependent ROS production is essential for CAM-mediated cell adhesion and CAM-dependent intracellular signaling. Importantly, CAMs also protect cells from the ROS-induced cell death by stimulating the synthesis of antioxidants and suppressing the cell death signaling. A better understanding of the role ROS play in controlling CAM functions and mechanisms of this control may pave the way to modulating the functions of CAMs in various disorders associated with abnormal cell adhesion.
ISSN:2073-4409
DOI:10.3390/cells14141098