Vitamin D intervention improves recognition memory and reduces hippocampal inflammation in rats submitted to an experimental model of cerebral palsy.
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| Titel: | Vitamin D intervention improves recognition memory and reduces hippocampal inflammation in rats submitted to an experimental model of cerebral palsy. |
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| Autoren: | Gouveia HJCB; Graduate Program in Nutrition, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil; Studies in Nutrition and Phenotypic Plasticity Unit, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil., Toscano AE; Graduate Program in Nutrition, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil; Studies in Nutrition and Phenotypic Plasticity Unit, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil; Graduate Program in Neuropsychiatry and Behavioral Sciences, Center for Medical Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-901, Brazil; Graduate Program in Nutrition, Physical Activity and Phenotypic Plasticity, Vitória Academic Center, Federal University of Pernambuco, Vitória de Santo Antão, Pernambuco 55608-680, Brazil; Nursing Unit, Vitória Academic Center, Federal University of Pernambuco, Vitória de Santo Antão, Pernambuco 55608-680, Brazil. Electronic address: aeltoscano@yahoo.com.br., da Silva MM; Graduate Program in Nutrition, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil; Studies in Nutrition and Phenotypic Plasticity Unit, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil., Marques da Silva LKT; Studies in Nutrition and Phenotypic Plasticity Unit, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil; Graduate Program in Nutrition, Physical Activity and Phenotypic Plasticity, Vitória Academic Center, Federal University of Pernambuco, Vitória de Santo Antão, Pernambuco 55608-680, Brazil., Cruz Silva MA; Studies in Nutrition and Phenotypic Plasticity Unit, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil., Dos Santos-Júnior OH; Studies in Nutrition and Phenotypic Plasticity Unit, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil; Graduate Program in Neuropsychiatry and Behavioral Sciences, Center for Medical Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-901, Brazil., Pontes Silva PB; Studies in Nutrition and Phenotypic Plasticity Unit, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil; Graduate Program in Neuropsychiatry and Behavioral Sciences, Center for Medical Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-901, Brazil., Silva Araújo ERD; Studies in Nutrition and Phenotypic Plasticity Unit, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil; Graduate Program in Neuropsychiatry and Behavioral Sciences, Center for Medical Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-901, Brazil., Manhães de Castro R; Graduate Program in Nutrition, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil; Studies in Nutrition and Phenotypic Plasticity Unit, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-420, Brazil; Graduate Program in Neuropsychiatry and Behavioral Sciences, Center for Medical Sciences, Federal University of Pernambuco, Recife, Pernambuco 50670-901, Brazil. |
| Quelle: | Behavioural brain research [Behav Brain Res] 2025 Oct 02; Vol. 494, pp. 115735. Date of Electronic Publication: 2025 Jul 12. |
| Publikationsart: | Journal Article |
| Sprache: | English |
| Info zur Zeitschrift: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| MeSH-Schlagworte: | Hippocampus*/drug effects , Hippocampus*/metabolism , Hippocampus*/pathology , Recognition, Psychology*/drug effects , Recognition, Psychology*/physiology , Vitamin D*/pharmacology , Vitamin D*/administration & dosage , Cerebral Palsy*/drug therapy , Cerebral Palsy*/complications , Cerebral Palsy*/physiopathology , Neuroinflammatory Diseases*/drug therapy, Animals ; Male ; Female ; Rats ; Disease Models, Animal ; Rats, Wistar ; Inflammation/drug therapy |
| Abstract: | Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Cerebral Palsy (CP) comprises neurological conditions characterized by abnormalities in movement, body posture, and altered muscle tone. Vitamin D (VitD) is important in bone metabolism and has anti-inflammatory, immune, and neuromodulatory properties. The aim of this study was thus to investigate the effects of VitD supplementation on parameters associated with memory, hippocampal inflammation, and neuronal loss in male and female rats with CP. The experimental model of CP included postnatal anoxia (P0-P1) and sensory-motor restriction (P2-P28). The pups were treated intraperitoneally with vehicle or VitD (5 μg/kg/day) during the first 30 days of postnatal life. The following were assessed: reflex-ontogeny, T-Maze and novel object recognition test (NORT), glial and neuronal responses, and inflammatory markers in the hippocampus. In male pups, CP caused delayed reflex maturation, impaired short- (P31) and long-term (P38) object recognition and spatial memory (P50-P52), reduced neuronal density, increased microglial area and density, and elevated expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). Female CP pups showed only delayed reflex maturation, impaired long-term object recognition, and increased microglial area. Intervention with VitD led to an earlier maturation of the righting reflex in males and females with CP, better performance in object recognition in the long term, a reduction in the area and density of microglia, as well as a reduction in the expression of TNF-α and IL-6 in CP males. These results confirm the greater resilience of females to the damage caused by CP and the promising effects of VitD in reducing hippocampal neuroinflammation. (Copyright © 2025 Elsevier B.V. All rights reserved.) |
| Contributed Indexing: | Keywords: Cerebral palsy; Cytokines; Memory; Microglia; Neurons; Vitamin D |
| Substance Nomenclature: | 1406-16-2 (Vitamin D) |
| Entry Date(s): | Date Created: 20250714 Date Completed: 20250907 Latest Revision: 20250907 |
| Update Code: | 20250908 |
| DOI: | 10.1016/j.bbr.2025.115735 |
| PMID: | 40659222 |
| Datenbank: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br />Cerebral Palsy (CP) comprises neurological conditions characterized by abnormalities in movement, body posture, and altered muscle tone. Vitamin D (VitD) is important in bone metabolism and has anti-inflammatory, immune, and neuromodulatory properties. The aim of this study was thus to investigate the effects of VitD supplementation on parameters associated with memory, hippocampal inflammation, and neuronal loss in male and female rats with CP. The experimental model of CP included postnatal anoxia (P0-P1) and sensory-motor restriction (P2-P28). The pups were treated intraperitoneally with vehicle or VitD (5 μg/kg/day) during the first 30 days of postnatal life. The following were assessed: reflex-ontogeny, T-Maze and novel object recognition test (NORT), glial and neuronal responses, and inflammatory markers in the hippocampus. In male pups, CP caused delayed reflex maturation, impaired short- (P31) and long-term (P38) object recognition and spatial memory (P50-P52), reduced neuronal density, increased microglial area and density, and elevated expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). Female CP pups showed only delayed reflex maturation, impaired long-term object recognition, and increased microglial area. Intervention with VitD led to an earlier maturation of the righting reflex in males and females with CP, better performance in object recognition in the long term, a reduction in the area and density of microglia, as well as a reduction in the expression of TNF-α and IL-6 in CP males. These results confirm the greater resilience of females to the damage caused by CP and the promising effects of VitD in reducing hippocampal neuroinflammation.<br /> (Copyright © 2025 Elsevier B.V. All rights reserved.) |
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| ISSN: | 1872-7549 |
| DOI: | 10.1016/j.bbr.2025.115735 |