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[Medication-related osteonecrosis of the jaw (MRONJ) during the treatment of cancer patients].

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Bibliographic Details
Title: [Medication-related osteonecrosis of the jaw (MRONJ) during the treatment of cancer patients].
Transliterated Title: Gyógyszer okozta állcsontnekrózis (MRONJ) a daganatos betegek kezelésekor.
Authors: Németh Z; Fogorvostudományi Kar, Semmelweis Egyetem, Arc-Állcsont-Szájsebészeti és Fogászati Klinika, Budapest, Hungary. nemeth.zsolt@semmelweis.hu., Bogdán S; Fogorvostudományi Kar, Semmelweis Egyetem, Arc-Állcsont-Szájsebészeti és Fogászati Klinika, Budapest, Hungary. nemeth.zsolt@semmelweis.hu., Joób-Fancsaly Á; Fogorvostudományi Kar, Semmelweis Egyetem, Arc-Állcsont-Szájsebészeti és Fogászati Klinika, Budapest, Hungary. nemeth.zsolt@semmelweis.hu., Vaszilkó M; Fogorvostudományi Kar, Semmelweis Egyetem, Arc-Állcsont-Szájsebészeti és Fogászati Klinika, Budapest, Hungary. nemeth.zsolt@semmelweis.hu., Tóth A; Fogorvostudományi Kar, Semmelweis Egyetem, Budapest, Hungary., Szentpéteri S; Fogorvostudományi Kar, Semmelweis Egyetem, Arc-Állcsont-Szájsebészeti és Fogászati Klinika, Budapest, Hungary. nemeth.zsolt@semmelweis.hu.
Source: Magyar onkologia [Magy Onkol] 2025 Jul 11; Vol. 69 (2), pp. 118-127. Date of Electronic Publication: 2025 Jun 20.
Publication Type: Journal Article; Review; English Abstract
Language: Hungarian
Journal Info: Publisher: Professional Publishing Hungary Kft Country of Publication: Hungary NLM ID: 9313833 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2060-0399 (Electronic) Linking ISSN: 00250244 NLM ISO Abbreviation: Magy Onkol Subsets: MEDLINE
Imprint Name(s): Publication: Budapest : Professional Publishing Hungary Kft.
Original Publication: Budapest : Medicina, [1957-
MeSH Terms: Bisphosphonate-Associated Osteonecrosis of the Jaw*/etiology , Bisphosphonate-Associated Osteonecrosis of the Jaw*/diagnosis , Bisphosphonate-Associated Osteonecrosis of the Jaw*/therapy , Neoplasms*/drug therapy , Bone Density Conservation Agents*/adverse effects , Osteonecrosis*/chemically induced , Angiogenesis Inhibitors*/adverse effects , Jaw Diseases*/chemically induced , Jaw Diseases*/diagnosis, Humans ; Risk Factors ; Aged ; Tooth Extraction/adverse effects ; Bone Remodeling/drug effects
Abstract: Medication-related osteonecrosis of the jaw (MRONJ), associated with antiresorptive and antiangiogenic/immunomodulatory therapies, is a severe condition affecting the jawbones. It most commonly occurs as a side effect of treatments for malignant tumors, osteological, and rheumatological diseases. Spontaneous healing is uncommon, and no definitive causal therapy exists. Surgical interventions, such as sequestrectomy or segmental resection, provide only temporary solutions, as the unpredictable involvement of the entire jawbone complicates the progression of the disease. The development of MRONJ is primarily linked to impaired bone remodeling, especially following trauma, such as tooth extractions. Patients over 65 years of age, those with weakened conditions, diabetes, ongoing steroid therapy, or poor oral hygiene are particularly affected, with the mandibular molar region being especially at risk. This study reviews the causative medications, risk factors, and the importance of early diagnosis and prevention. It also explores research directions aimed at achieving more effective treatments.
Substance Nomenclature: 0 (Bone Density Conservation Agents)
0 (Angiogenesis Inhibitors)
Entry Date(s): Date Created: 20250711 Date Completed: 20250711 Latest Revision: 20250711
Update Code: 20250711
PMID: 40643448
Database: MEDLINE
Description
Abstract:Medication-related osteonecrosis of the jaw (MRONJ), associated with antiresorptive and antiangiogenic/immunomodulatory therapies, is a severe condition affecting the jawbones. It most commonly occurs as a side effect of treatments for malignant tumors, osteological, and rheumatological diseases. Spontaneous healing is uncommon, and no definitive causal therapy exists. Surgical interventions, such as sequestrectomy or segmental resection, provide only temporary solutions, as the unpredictable involvement of the entire jawbone complicates the progression of the disease. The development of MRONJ is primarily linked to impaired bone remodeling, especially following trauma, such as tooth extractions. Patients over 65 years of age, those with weakened conditions, diabetes, ongoing steroid therapy, or poor oral hygiene are particularly affected, with the mandibular molar region being especially at risk. This study reviews the causative medications, risk factors, and the importance of early diagnosis and prevention. It also explores research directions aimed at achieving more effective treatments.
ISSN:2060-0399