High ciguatoxin-producing Gambierdiscus clade (Gonyaulacales, Dinophyceae) as a source of toxins causing ciguatera poisoning.
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| Názov: | High ciguatoxin-producing Gambierdiscus clade (Gonyaulacales, Dinophyceae) as a source of toxins causing ciguatera poisoning. |
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| Autori: | Murray SA; University of Technology Sydney, School of Life Sciences, PO Box 123 Broadway, Sydney, NSW 2007, Australia. Electronic address: Shauna.Murray@uts.edu.au., Verma A; University of Technology Sydney, School of Life Sciences, PO Box 123 Broadway, Sydney, NSW 2007, Australia., Hoppenrath M; Senckenberg am Meer, German Centre for Marine Biodiversity Research (DZMB), Südstrand 44, D-26382 Wilhelmshaven, Germany., Harwood DT; Cawthron Institute, 98 Halifax Street East, Nelson 7010, New Zealand., Murray JS; Cawthron Institute, 98 Halifax Street East, Nelson 7010, New Zealand., Smith KF; Cawthron Institute, 98 Halifax Street East, Nelson 7010, New Zealand., Lewis R; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Finch SC; AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand., Islam SS; Institute for Marine and Antarctic Studies (IMAS), University of Tasmania, Private Bag 129, Hobart 7001, Tasmania, Australia., Ashfaq A; University of Technology Sydney, School of Life Sciences, PO Box 123 Broadway, Sydney, NSW 2007, Australia., De Azevedo CD; University of Technology Sydney, School of Life Sciences, PO Box 123 Broadway, Sydney, NSW 2007, Australia., Bolch CJS; Institute for Marine and Antarctic Studies (IMAS), University of Tasmania, Private Bag 129, Hobart 7001, Tasmania, Australia. |
| Zdroj: | The Science of the total environment [Sci Total Environ] 2025 Sep 10; Vol. 994, pp. 179990. Date of Electronic Publication: 2025 Jul 07. |
| Spôsob vydávania: | Journal Article |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier. |
| Výrazy zo slovníka MeSH: | Ciguatoxins*/analysis , Dinoflagellida*/metabolism , Dinoflagellida*/genetics , Ciguatera Poisoning*/epidemiology, Phylogeny |
| Abstrakt: | Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Shauna Murray, Christopher Bolch, Tim Harwood reports financial support was provided by Australian Research Council. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Ciguatera Poisoning (CP) is caused by neurotoxins (Ciguatoxins, CTXs) produced by microbial eukaryotes (Gambierdiscus, Fukuyoa: Dinophyceae) that accumulate in seafood and can result in severe human illness. More than 80 % of the world's CP occurs in the South Pacific, and climate change is projected to increase cases. However, our understanding of CP is hindered because Gambierdiscus spp. directly associated with CP remain uncertain. Most Gambierdiscus/Fukuyoa spp. demonstrate little CTX-like activity, which appears to be unlikely to cause CP at scale. We characterised Gambierdiscus from the Great Barrier Reef (Australia), a region with endemic CP, including G. bagnisii sp. nov., using light and scanning electron microscopy, morphometric analysis, and phylogenomics. Using LC-MS/MS, G. holmesii produced M-seco-CTX4A/B, the second taxon after G. polynesiensis with chemically detectable CTXs in the Pacific region. G. bagnisii sp. nov. and G. holmesii produced an uncharacterised compound found previously only in G. polynesiensis, however its bioactivity and relationship, if any, to CP is unknown. A close relationship between G. bagnisii sp. nov., G. holmesii, and G. polynesiensis (as Clade III) was found, and taxa were distributed from the far north to southern Great Barrier Reef and throughout the South Pacific. Our analyses indicate that CTXs produced by Gambierdiscus from Clade III, such as G. polynesiensis, are important in relation to CP and might be responsible for the majority of CP in the South Pacific. (Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Contributed Indexing: | Keywords: Ciguatera poisoning (CP); Dinophyceae; Liquid chromatography-tandem mass spectrometry (LC-MS/MS); Morphology; Phylogeny; Ribosomal RNA |
| Substance Nomenclature: | 11050-21-8 (Ciguatoxins) |
| Entry Date(s): | Date Created: 20250708 Date Completed: 20250809 Latest Revision: 20250809 |
| Update Code: | 20250811 |
| DOI: | 10.1016/j.scitotenv.2025.179990 |
| PMID: | 40628156 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Shauna Murray, Christopher Bolch, Tim Harwood reports financial support was provided by Australian Research Council. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br />Ciguatera Poisoning (CP) is caused by neurotoxins (Ciguatoxins, CTXs) produced by microbial eukaryotes (Gambierdiscus, Fukuyoa: Dinophyceae) that accumulate in seafood and can result in severe human illness. More than 80 % of the world's CP occurs in the South Pacific, and climate change is projected to increase cases. However, our understanding of CP is hindered because Gambierdiscus spp. directly associated with CP remain uncertain. Most Gambierdiscus/Fukuyoa spp. demonstrate little CTX-like activity, which appears to be unlikely to cause CP at scale. We characterised Gambierdiscus from the Great Barrier Reef (Australia), a region with endemic CP, including G. bagnisii sp. nov., using light and scanning electron microscopy, morphometric analysis, and phylogenomics. Using LC-MS/MS, G. holmesii produced M-seco-CTX4A/B, the second taxon after G. polynesiensis with chemically detectable CTXs in the Pacific region. G. bagnisii sp. nov. and G. holmesii produced an uncharacterised compound found previously only in G. polynesiensis, however its bioactivity and relationship, if any, to CP is unknown. A close relationship between G. bagnisii sp. nov., G. holmesii, and G. polynesiensis (as Clade III) was found, and taxa were distributed from the far north to southern Great Barrier Reef and throughout the South Pacific. Our analyses indicate that CTXs produced by Gambierdiscus from Clade III, such as G. polynesiensis, are important in relation to CP and might be responsible for the majority of CP in the South Pacific.<br /> (Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.) |
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| ISSN: | 1879-1026 |
| DOI: | 10.1016/j.scitotenv.2025.179990 |