Disruption of the linear relationship between recognition memory and local functional connectivity of left perirhinal cortex in rat after acute 2.856 GHz microwave exposure.
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| Názov: | Disruption of the linear relationship between recognition memory and local functional connectivity of left perirhinal cortex in rat after acute 2.856 GHz microwave exposure. |
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| Autori: | Zhao J; Beijing Institute of Radiation Medicine, Beijing 100850, China., Yue H; Beijing Institute of Radiation Medicine, Beijing 100850, China., Wang K; Beijing Institute of Radiation Medicine, Beijing 100850, China., Sun Y; Beijing Institute of Radiation Medicine, Beijing 100850, China., Zhao L; Beijing Institute of Radiation Medicine, Beijing 100850, China., Wang H; Beijing Institute of Radiation Medicine, Beijing 100850, China., Zhang J; Beijing Institute of Radiation Medicine, Beijing 100850, China., Xu X; Beijing Institute of Radiation Medicine, Beijing 100850, China., Yao B; Beijing Institute of Radiation Medicine, Beijing 100850, China., Dong J; Beijing Institute of Radiation Medicine, Beijing 100850, China., Wang H; Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address: smart106@126.com., Zuo Z; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: zuozt@ibp.ac.cn., Peng R; Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address: ruiyunpeng18@126.com. |
| Zdroj: | Brain research [Brain Res] 2025 Oct 01; Vol. 1864, pp. 149816. Date of Electronic Publication: 2025 Jul 05. |
| Spôsob vydávania: | Journal Article |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press. |
| Výrazy zo slovníka MeSH: | Microwaves*/adverse effects , Recognition, Psychology*/radiation effects , Recognition, Psychology*/physiology , Perirhinal Cortex*/radiation effects , Perirhinal Cortex*/physiopathology , Perirhinal Cortex*/diagnostic imaging , Perirhinal Cortex*/physiology, Animals ; Male ; Rats ; Magnetic Resonance Imaging/methods ; Rats, Sprague-Dawley ; Hippocampus/radiation effects ; Neural Pathways/radiation effects ; Nerve Net/radiation effects |
| Abstrakt: | Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Objective: With the widespread utilization of S band (2 GHz ∼ 4 GHz) microwave (MW) in communication, its potential health risks have drawn significant attention. The purpose of this study was to investigate the impacts of acute 2.856 GHz MW exposure on recognition memory, its corresponding functional brain network, and the relationships between them in rats. Methods: Novel object recognition (NOR) tests were conducted to examine the influence of 50 mW/cm 2 acute 2.856 GHz MW on rat's recognition memory. Subsequently, resting state functional magnetic resonance imaging (rs-fMRI) was implemented to investigate the changes in the topological characteristics, long-range functional connectivity (FC), local FC assessed by regional homogeneity (ReHo), and fractional amplitude of low frequency fluctuation (fALFF) of rats' brain network related to recognition memory. Furthermore, the relationships between recognition memory and the potentially changed functional characteristics were investigated. Results: Our findings revealed that the acute MW exposure induced recognition memory decline in rats. Though no significant alterations were detected in topological properties, long-range FCs, and fALFF within the brain network related to recognition memory, the local FCs of bilateral perirhinal cortex and right hippocampus in rats exhibited marginally significant increases following the MW exposure. Moreover, in the Sham group, the local FC of the left perirhinal cortex demonstrated a significantly positive linear correlation with recognition memory ability (p = 0.0193, r = 0.7182). However, this linear relationship was disrupted after the MW exposure. Conclusion: In conclusion, acute 2.856 GHz MW exposure can induce recognition memory impairments in rats. There is a positive linear relationship between recognition memory and the local FC of the left perirhinal cortex in normal rats. However, this relationship is disrupted after MW exposure, potentially due to maladaptive reorganization or failure of compensation within the brain region. (Copyright © 2025 Elsevier B.V. All rights reserved.) |
| Contributed Indexing: | Keywords: Acute exposure; Brain network; Local functional connectivity; Long-range functional connectivity; Microwave; Rats; Recognition memory |
| Entry Date(s): | Date Created: 20250706 Date Completed: 20250903 Latest Revision: 20250903 |
| Update Code: | 20250904 |
| DOI: | 10.1016/j.brainres.2025.149816 |
| PMID: | 40618867 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br />Objective: With the widespread utilization of S band (2 GHz ∼ 4 GHz) microwave (MW) in communication, its potential health risks have drawn significant attention. The purpose of this study was to investigate the impacts of acute 2.856 GHz MW exposure on recognition memory, its corresponding functional brain network, and the relationships between them in rats.<br />Methods: Novel object recognition (NOR) tests were conducted to examine the influence of 50 mW/cm <sup>2</sup> acute 2.856 GHz MW on rat's recognition memory. Subsequently, resting state functional magnetic resonance imaging (rs-fMRI) was implemented to investigate the changes in the topological characteristics, long-range functional connectivity (FC), local FC assessed by regional homogeneity (ReHo), and fractional amplitude of low frequency fluctuation (fALFF) of rats' brain network related to recognition memory. Furthermore, the relationships between recognition memory and the potentially changed functional characteristics were investigated.<br />Results: Our findings revealed that the acute MW exposure induced recognition memory decline in rats. Though no significant alterations were detected in topological properties, long-range FCs, and fALFF within the brain network related to recognition memory, the local FCs of bilateral perirhinal cortex and right hippocampus in rats exhibited marginally significant increases following the MW exposure. Moreover, in the Sham group, the local FC of the left perirhinal cortex demonstrated a significantly positive linear correlation with recognition memory ability (p = 0.0193, r = 0.7182). However, this linear relationship was disrupted after the MW exposure.<br />Conclusion: In conclusion, acute 2.856 GHz MW exposure can induce recognition memory impairments in rats. There is a positive linear relationship between recognition memory and the local FC of the left perirhinal cortex in normal rats. However, this relationship is disrupted after MW exposure, potentially due to maladaptive reorganization or failure of compensation within the brain region.<br /> (Copyright © 2025 Elsevier B.V. All rights reserved.) |
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| ISSN: | 1872-6240 |
| DOI: | 10.1016/j.brainres.2025.149816 |