Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study.
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| Názov: | Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study. |
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| Autori: | Rong X; Nanshan School, Guangzhou Medical University, Guangzhou, China., Yu D; Nanshan School, Guangzhou Medical University, Guangzhou, China., Zhao W; School of Pediatrics, Guangzhou Medical University, Guangzhou, China., Xiao J; Nanshan School, Guangzhou Medical University, Guangzhou, China., Feng D; Nanshan School, Guangzhou Medical University, Guangzhou, China., Chen G; Nanshan School, Guangzhou Medical University, Guangzhou, China., Cao Z; Nanshan School, Guangzhou Medical University, Guangzhou, China., Shu L; Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. |
| Zdroj: | Frontiers in public health [Front Public Health] 2025 Jun 02; Vol. 13, pp. 1598497. Date of Electronic Publication: 2025 Jun 02 (Print Publication: 2025). |
| Spôsob vydávania: | Journal Article |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers Editorial Office |
| Výrazy zo slovníka MeSH: | Epilepsy*/epidemiology , Epilepsy*/mortality , Health Promotion* , Social Factors* , Health Status Disparities* , Cost of Illness*, Humans ; Female ; Male ; Adult ; Middle Aged ; Global Health/statistics & numerical data ; Global Burden of Disease/trends ; Socioeconomic Factors ; Aged ; Adolescent ; Incidence |
| Abstrakt: | Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Background: Idiopathic epilepsy is a major global health burden that causes premature death and disability. Previous studies have systematically analyzed trends in the burden of idiopathic epilepsy. However, analyses of the impact of social factors, health campaigns and policies on the burden of idiopathic epilepsy are lacking. This study aims to fill that gap. Methods: We used data from the 2021 Global Burden of Disease (GBD) and calculated the estimated annual percentage changes (EAPC) to assess trends. Decomposition analysis breaks down changes in the burden of idiopathic epilepsy into three factors. Correlation analysis measures the association between the EAPC and social development. Inequality analysis illustrates the disparity in the burden of idiopathic epilepsy among countries. Generalized difference-in-differences (GDID) and synthetic difference-in-differences (SDID) analyses are used to quantify the impact of health campaigns or policies on the burden of idiopathic epilepsy. Results: With respect to incidence, aging had a negative impact. The correlation between the sociodemographic index (SDI) and EAPC had a rho value of -0.18. The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes. Conclusion: This study explores the impact of social factors and health campaigns on the burden of idiopathic epilepsy. We emphasize the need for targeted prevention and treatment strategies to effectively address the burden of idiopathic epilepsy. (Copyright © 2025 Rong, Yu, Zhao, Xiao, Feng, Chen, Cao and Shu.) |
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| Contributed Indexing: | Keywords: disability-adjusted life years; generalized difference-in-differences; global burden of disease; idiopathic epilepsy; inequality; synthetic difference-in-differences |
| Entry Date(s): | Date Created: 20250618 Date Completed: 20250618 Latest Revision: 20250620 |
| Update Code: | 20250620 |
| PubMed Central ID: | PMC12171163 |
| DOI: | 10.3389/fpubh.2025.1598497 |
| PMID: | 40529696 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br />Background: Idiopathic epilepsy is a major global health burden that causes premature death and disability. Previous studies have systematically analyzed trends in the burden of idiopathic epilepsy. However, analyses of the impact of social factors, health campaigns and policies on the burden of idiopathic epilepsy are lacking. This study aims to fill that gap.<br />Methods: We used data from the 2021 Global Burden of Disease (GBD) and calculated the estimated annual percentage changes (EAPC) to assess trends. Decomposition analysis breaks down changes in the burden of idiopathic epilepsy into three factors. Correlation analysis measures the association between the EAPC and social development. Inequality analysis illustrates the disparity in the burden of idiopathic epilepsy among countries. Generalized difference-in-differences (GDID) and synthetic difference-in-differences (SDID) analyses are used to quantify the impact of health campaigns or policies on the burden of idiopathic epilepsy.<br />Results: With respect to incidence, aging had a negative impact. The correlation between the sociodemographic index (SDI) and EAPC had a rho value of -0.18. The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.<br />Conclusion: This study explores the impact of social factors and health campaigns on the burden of idiopathic epilepsy. We emphasize the need for targeted prevention and treatment strategies to effectively address the burden of idiopathic epilepsy.<br /> (Copyright © 2025 Rong, Yu, Zhao, Xiao, Feng, Chen, Cao and Shu.) |
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| ISSN: | 2296-2565 |
| DOI: | 10.3389/fpubh.2025.1598497 |