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Integrating magnetic field-initiated thermal-thermodynamic therapy and immune checkpoint blockade to boost antitumor immunotherapy.

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Title: Integrating magnetic field-initiated thermal-thermodynamic therapy and immune checkpoint blockade to boost antitumor immunotherapy.
Authors: Tao C; Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China; State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China., Wen M; State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China., Qiu P; State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China., Niu S; State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China., Wang X; State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China., Yu N; State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China., Li M; Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China., Chen Z; Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China; State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. Electronic address: zgchen@dhu.edu.cn., Pan L; Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address: panlong@tongji.edu.cn.
Source: Journal of colloid and interface science [J Colloid Interface Sci] 2025 Dec; Vol. 699 (Pt 1), pp. 138113. Date of Electronic Publication: 2025 Jun 06.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: MEDLINE
Imprint Name(s): Publication: Orlando, FL : Academic Press
Original Publication: New York.
MeSH Terms: Immunotherapy*/methods , Immune Checkpoint Inhibitors*/pharmacology , Immune Checkpoint Inhibitors*/chemistry , Hyperthermia, Induced* , Magnetic Fields* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Neoplasms*/therapy , Neoplasms*/immunology, Animals ; Humans ; Mice ; Apoptosis/drug effects ; Thermodynamics ; Particle Size ; Female ; Cell Line, Tumor
Abstract: Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Immune checkpoint blockade (ICB) immunotherapy has transformed cancer treatment by unleashing anti-tumor immune responses. However, its effectiveness in solid tumors is often limited by weak or insufficient immune activation. Herein, an immune-adjuvant strategy has been developed by integrating ICB and alternating magnetic field (AMF) activatable nanoagents to augment antitumor immunotherapy. The AMF-initiated nanoagents are composed of Fe 3 O 4 core and mesoporous organosilica shell (MOS) loaded with radical generator 2,2'-azabis(2-imidazoline) dihydrochloride (AIPH), abbreviated as Fe 3 O 4 @MOS-AIPH. The MOS shell with SSSS- bonds reacts with reductive glutathione (GSH), releasing Fe 3 O 4 and AIPH. The Fe 3 O 4 can rapidly heat up under AMF irradiation and decompose AIPH into alkyl free radicals, which promotes cell apoptosis via magnetic hyperthermia therapy and thermodynamic therapy (MHT/TDT), thereby effectively inducing immunogenic cell death (ICD) for subsequent dendritic cell maturation. By integrating MHT/TDT and anti-PD-L1 (anti-programmed death-ligand 1 antibody), the antitumor immune response has been greatly enhanced, resulting in the elimination of the primary tumor and effective suppression of distant tumors and lung metastases. The integration of AMF-initiated nanoagents and ICB provides insights into regulating immune cells through multimodal approaches.
(Copyright © 2025 Elsevier Inc. All rights reserved.)
Contributed Indexing: Keywords: Immunotherapy; Magnetothermal; Mesoporous organosilica; Tetrasulfide bond; Thermodynamic
Substance Nomenclature: 0 (Immune Checkpoint Inhibitors)
0 (Antineoplastic Agents)
Entry Date(s): Date Created: 20250616 Date Completed: 20250730 Latest Revision: 20250730
Update Code: 20250731
DOI: 10.1016/j.jcis.2025.138113
PMID: 40523335
Database: MEDLINE
Description
Abstract:Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br />Immune checkpoint blockade (ICB) immunotherapy has transformed cancer treatment by unleashing anti-tumor immune responses. However, its effectiveness in solid tumors is often limited by weak or insufficient immune activation. Herein, an immune-adjuvant strategy has been developed by integrating ICB and alternating magnetic field (AMF) activatable nanoagents to augment antitumor immunotherapy. The AMF-initiated nanoagents are composed of Fe <subscript>3</subscript> O <subscript>4</subscript> core and mesoporous organosilica shell (MOS) loaded with radical generator 2,2'-azabis(2-imidazoline) dihydrochloride (AIPH), abbreviated as Fe <subscript>3</subscript> O <subscript>4</subscript> @MOS-AIPH. The MOS shell with SSSS- bonds reacts with reductive glutathione (GSH), releasing Fe <subscript>3</subscript> O <subscript>4</subscript> and AIPH. The Fe <subscript>3</subscript> O <subscript>4</subscript> can rapidly heat up under AMF irradiation and decompose AIPH into alkyl free radicals, which promotes cell apoptosis via magnetic hyperthermia therapy and thermodynamic therapy (MHT/TDT), thereby effectively inducing immunogenic cell death (ICD) for subsequent dendritic cell maturation. By integrating MHT/TDT and anti-PD-L1 (anti-programmed death-ligand 1 antibody), the antitumor immune response has been greatly enhanced, resulting in the elimination of the primary tumor and effective suppression of distant tumors and lung metastases. The integration of AMF-initiated nanoagents and ICB provides insights into regulating immune cells through multimodal approaches.<br /> (Copyright © 2025 Elsevier Inc. All rights reserved.)
ISSN:1095-7103
DOI:10.1016/j.jcis.2025.138113