Short Anagen Hair Syndrome and Its Association With WNT10A Gene Variants: A Report of Three Pediatric Cases.
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| Title: | Short Anagen Hair Syndrome and Its Association With WNT10A Gene Variants: A Report of Three Pediatric Cases. |
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| Authors: | Román Mendoza NM; Department of Dermatology, Hospital Infantil Universitario Niño Jesus, Madrid, Spain., Louka M; Department of Dermatology, Hospital Infantil Universitario Niño Jesus, Madrid, Spain., García-González S; Department of Dermatology, Hospital Infantil Universitario Niño Jesus, Madrid, Spain., Ortiz-Cabrera NV; Department of Genetics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Garoz BF; Department of Genetics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Noguera-Morel L; Department of Dermatology, Hospital Infantil Universitario Niño Jesus, Madrid, Spain., Hernández-Martín Á; Department of Dermatology, Hospital Infantil Universitario Niño Jesus, Madrid, Spain. |
| Source: | Pediatric dermatology [Pediatr Dermatol] 2025 Nov-Dec; Vol. 42 (6), pp. 1169-1171. Date of Electronic Publication: 2025 May 29. |
| Publication Type: | Journal Article; Case Reports |
| Language: | English |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 8406799 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1470 (Electronic) Linking ISSN: 07368046 NLM ISO Abbreviation: Pediatr Dermatol Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2010->: Hoboken, NJ : Wiley Original Publication: [Boston, MA] : Blackwell Scientific Publications, [1983- |
| MeSH Terms: | Wnt Proteins*/genetics , Hair*/abnormalities , Hair*/growth & development , Hair Diseases*/genetics, Humans ; Female ; Male ; Child ; Adolescent ; Child, Preschool |
| Abstract: | Short anagen hair syndrome (SAHS) is a rare hair disorder characterized by a shortened anagen phase, limiting hair growth to a few centimeters. SAHS is a benign condition often improving after puberty, with diagnosis supported by clinical, trichological, and genetic findings. We report three pediatric cases of persistently short hair, all with negative hair pull tests and trichogram findings revealing club-shaped roots, tapering, and hair shaft diameter variability. Genetic testing identified the c.682 T>A;p.(Phe228Ile) variant in heterozygosity in the WNT10A gene in two patients, a variant reported as a risk factor for the condition. (© 2025 Wiley Periodicals LLC.) |
| References: | M. M. Barraud‐Klenovsek and R. M. Trüeb, “Congenital Hypotrichosis due to Short Anagen,” British Journal of Dermatology 143, no. 3 (2000): 612–617, https://doi.org/10.1111/j.1365‐2133.2000.03720.x. P. J. W. Kersey, “Tricho‐Dental Syndrome: A Disorder With a Short Hair Cycle,” British Journal of Dermatology 116, no. 2 (1987): 259–263, https://doi.org/10.1111/j.1365‐2133.1987.tb05824.x. N. Cesarato, A. Schwieger‐Briel, Y. Gossmann, et al., “Short Anagen Hair Syndrome: Association With Mono‐ and Biallelic Variants in WNT10A and a Genetic Overlap With Male Pattern Hair Loss,” British Journal of Dermatology 189, no. 6 (2023): 741–749, https://doi.org/10.1093/bjd/ljad314. R. Mo, Z. Chen, Y. Yang, and Y. Jiang, “Novel Variant in WNT10A Caused Short Anagen Hair Syndrome in a Chinese Pedigree,” Journal of the European Academy of Dermatology and Venereology 38, no. 11 (2024): 976–978, https://doi.org/10.1111/jdv.20035. M. Starace, C. Gurioli, M. A. Carpanese, et al., “Short Anagen Syndrome: A Case Series and Algorithm for Diagnosis,” Pediatric Dermatology 38, no. 5 (2021): 1157–1161, https://doi.org/10.1111/pde.14750. S. H. Park, J. E. Seol, D. H. Kim, and H. Kim, “Analysis of Microscopic Examination of Pulled out Hair in Telogen Effluvium Patients,” Annals of Dermatology 32, no. 2 (2020): 141–145, https://doi.org/10.5021/ad.2020.32.2.141. K. M. Stieler, T. Bartzela, C. Finke, U. Blume‐Peytavi, and J. Fischer, “Congenital Hair Anomaly in Association With Hypodontia of Permanent Teeth: A Quiz,” Acta Dermato‐Venereologica 100, no. 14 (2020): 5841, https://doi.org/10.2340/00015555‐3592. B. J. Doolan, A. Onoufriadis, P. Kantaputra, and J. A. McGrath, “WNT10A, Dermatology and Dentistry,” British Journal of Dermatology 185, no. 6 (2021): 1105–1111, https://doi.org/10.1111/bjd.20601. P. García‐Martín, A. Hernández‐Martín, and A. Torrelo, “Displasias Ectodérmicas: Revisión Clínica y Molecular,” Actas Dermo‐Sifiliográficas 104, no. 6 (2013): 451–470, https://doi.org/10.1016/j.ad.2012.07.012. K. J. Karczewski, L. C. Francioli, G. Tiao, et al., “The Mutational Constraint Spectrum Quantified From Variation in 141,456 Humans,” Nature 581, no. 7809 (2020): 434–443, https://doi.org/10.1038/s41586‐020‐2308‐7. |
| Contributed Indexing: | Keywords: WNT10A; hair disorders; short anagen hair syndrome; trichogram |
| Substance Nomenclature: | 0 (WNT10A protein, human) 0 (Wnt Proteins) |
| Entry Date(s): | Date Created: 20250529 Date Completed: 20251125 Latest Revision: 20251125 |
| Update Code: | 20251126 |
| DOI: | 10.1111/pde.15976 |
| PMID: | 40439174 |
| Database: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Short anagen hair syndrome (SAHS) is a rare hair disorder characterized by a shortened anagen phase, limiting hair growth to a few centimeters. SAHS is a benign condition often improving after puberty, with diagnosis supported by clinical, trichological, and genetic findings. We report three pediatric cases of persistently short hair, all with negative hair pull tests and trichogram findings revealing club-shaped roots, tapering, and hair shaft diameter variability. Genetic testing identified the c.682 T>A;p.(Phe228Ile) variant in heterozygosity in the WNT10A gene in two patients, a variant reported as a risk factor for the condition.<br /> (© 2025 Wiley Periodicals LLC.) |
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| ISSN: | 1525-1470 |
| DOI: | 10.1111/pde.15976 |