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Mortality and Ventricular Arrhythmia in Patients with Early Ventricular Repolarization.

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Název: Mortality and Ventricular Arrhythmia in Patients with Early Ventricular Repolarization.
Transliterovaný název: Mortalidade e Arritmia Ventricular em Pacientes com Repolarização Precoce.
Autoři: Baldisserotto H; Programa de Pós-Graduação em Ciências da Saúde: Cardiologia e Ciências Cardiovasculares, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Lima BA; Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS - Brasil., Saffi MAL; Programa de Pós-Graduação em Ciências da Saúde: Cardiologia e Ciências Cardiovasculares, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Silveira ADD; Programa de Pós-Graduação em Ciências da Saúde: Cardiologia e Ciências Cardiovasculares, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Baldisserotto ML; Departamento de Psicometria, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ - Brasil., Leiria TLL; Programa de Pós-Graduação em Ciências da Saúde: Cardiologia e Ciências Cardiovasculares, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil.
Zdroj: Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2025 Apr; Vol. 122 (4), pp. e20240516.
Způsob vydávání: Journal Article
Jazyk: Portuguese; English
Informace o časopise: Publisher: Sociedad Brasileira De Cardiologia Country of Publication: Brazil NLM ID: 0421031 Publication Model: Print Cited Medium: Internet ISSN: 1678-4170 (Electronic) Linking ISSN: 0066782X NLM ISO Abbreviation: Arq Bras Cardiol Subsets: MEDLINE
Imprint Name(s): Original Publication: Sao Paulo : Sociedad Brasileira De Cardiologia
Výrazy ze slovníku MeSH: Ventricular Fibrillation*/mortality , Ventricular Fibrillation*/physiopathology , Arrhythmias, Cardiac*/mortality , Arrhythmias, Cardiac*/physiopathology, Humans ; Male ; Female ; Middle Aged ; Brazil/epidemiology ; Retrospective Studies ; Adult ; Electrocardiography ; Aged ; Risk Factors ; Tachycardia, Ventricular/mortality ; Epidemiologic Methods
Abstrakt: Background: Recent research has linked early repolarization (ER) with increased ventricular fibrillation risk, especially in leads V1-V3 and in inferior and lateral regions. However, data on the Brazilian population are limited.
Objective: To estimate the impact of ER on survival and the occurrence of ventricular arrhythmias (VA) in patients over a 10-year period at a university hospital.
Methods: This retrospective cohort study included patients with ER on electrocardiogram from the hospital database. Descriptive analysis was conducted to describe patients' profile and characteristics. Kaplan-Meier method was utilized to analyze survival curves, with the log-rank test employed to assess differences between ER types. Cox regression models were applied to evaluate the risks of death and VA, calculating both gross and adjusted hazard ratios. The level of significance adopted in the statistical analysis was 5%.
Results: The study population was predominantly male, average age of 45.6 years; 2.7% experienced VA (five in the group with lateral ER, four in the group with inferior ER group, and four in the ER inferolateral group). Significant differences were observed in age, sex, and HFrEF between the groups. Regarding all-cause mortality, 2.3% of patients died (five in the group with lateral ER, one in the group with inferior ER group, and five in the ER inferolateral group). Only age showed a statistically significant difference. There were significant differences in both death and VA between the groups (p=0.7 and p=0.5, respectively).
Conclusion: ER did not lead to a higher incidence of VA or all-cause mortality in this cohort.
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Contributed Indexing: Local Abstract: [Publisher, Portuguese] Estudos recentes associaram a repolarização precoce (RP) com um risco de fibrilação ventricular aumentado, especialmente nas derivações V1-V3 e nas regiões inferior e lateral. No entanto, dados sobre a população brasileira são limitados. [Publisher, Portuguese] Estimar o impacto da RP na sobrevida e na ocorrência de arritmias ventriculares (AVs) em um período de 10 anos em um hospital universitário. [Publisher, Portuguese] Este estudo retrospectivo do tipo coorte incluiu pacientes com RP no eletrocardiograma a partir do banco de dados do hospital. Análise descritiva foi conduzida para descrever o perfil e as características dos pacientes. O método de Kaplan-Meier foi usado para avaliar as diferenças entre os tipos de RP. Modelos de regressão de Cox foram aplicados para avaliar os riscos de morte e AV. calculando os hazard ratios brutos e ajustados. O nível de significância adotado na análise estatística foi de 5%. [Publisher, Portuguese] A população do estudo foi predominantemente do sexo masculino, com idade média de 45,6 anos; 2,7% apresentaram AV (cinco no grupo com RP lateral, quatro no grupo com RP inferior e quatro no grupo com RP ínfero-lateral). Foram observadas diferenças significativas na idade, sexo, e ocorrência de insuficiência cardíaca com fração de ejeção reduzida entre os grupos. Em relação à mortalidade por todas as causas, 2,3% dos pacientes foram a óbito (cinco no grupo com RP lateral, um no grupo com RP inferior e cinco no grupo com RP ínfero-lateral). Somente idade mostrou uma diferença estatisticamente significativa. Observou-se diferenças significativas na ocorrência de morte e de AV entre os grupos (p=0,7 e p=0,5, respectivamente). [Publisher, Portuguese] A RP não levou a uma maior incidência de AV nem de mortalidade por todas as causas na população estudada.
Entry Date(s): Date Created: 20250514 Date Completed: 20250515 Latest Revision: 20250530
Update Code: 20250530
PubMed Central ID: PMC12108119
DOI: 10.36660/abc.20240516
PMID: 40367002
Databáze: MEDLINE
Popis
Abstrakt:Background: Recent research has linked early repolarization (ER) with increased ventricular fibrillation risk, especially in leads V1-V3 and in inferior and lateral regions. However, data on the Brazilian population are limited.<br />Objective: To estimate the impact of ER on survival and the occurrence of ventricular arrhythmias (VA) in patients over a 10-year period at a university hospital.<br />Methods: This retrospective cohort study included patients with ER on electrocardiogram from the hospital database. Descriptive analysis was conducted to describe patients' profile and characteristics. Kaplan-Meier method was utilized to analyze survival curves, with the log-rank test employed to assess differences between ER types. Cox regression models were applied to evaluate the risks of death and VA, calculating both gross and adjusted hazard ratios. The level of significance adopted in the statistical analysis was 5%.<br />Results: The study population was predominantly male, average age of 45.6 years; 2.7% experienced VA (five in the group with lateral ER, four in the group with inferior ER group, and four in the ER inferolateral group). Significant differences were observed in age, sex, and HFrEF between the groups. Regarding all-cause mortality, 2.3% of patients died (five in the group with lateral ER, one in the group with inferior ER group, and five in the ER inferolateral group). Only age showed a statistically significant difference. There were significant differences in both death and VA between the groups (p=0.7 and p=0.5, respectively).<br />Conclusion: ER did not lead to a higher incidence of VA or all-cause mortality in this cohort.
ISSN:1678-4170
DOI:10.36660/abc.20240516