View in EDS

LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis.

Saved in:
Bibliographic Details
Title: LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis.
Authors: Yin X; Department of Neurosurgery, Peking University Third Hospital, Beijing, China., Chen X; Department of Neurosurgery, Peking University Third Hospital, Beijing, China., Wang T; Department of Neurosurgery, Peking University Third Hospital, Beijing, China., Yang J; Department of Neurosurgery, Peking University Third Hospital, Beijing, China., Yu J; Department of Neurosurgery, Peking University Third Hospital, Beijing, China., Yang J; Department of Neurosurgery, Peking University Third Hospital, Beijing, China.; Center for Precision Neurosurgery and Oncology, Peking University Health Science Center, Beijing, China.
Source: Epigenetics [Epigenetics] 2025 Dec; Vol. 20 (1), pp. 2487317. Date of Electronic Publication: 2025 May 13.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265293 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-2308 (Electronic) Linking ISSN: 15592294 NLM ISO Abbreviation: Epigenetics Subsets: MEDLINE
Imprint Name(s): Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Georgetown, Tex. : Landes Bioscience, c2006-
MeSH Terms: RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Plaque, Atherosclerotic*/genetics , Plaque, Atherosclerotic*/metabolism , Plaque, Atherosclerotic*/pathology , Macrophages*/metabolism , Phagocytosis* , Atherosclerosis*/genetics , Atherosclerosis*/pathology , Atherosclerosis*/metabolism, Animals ; Mice ; RAW 264.7 Cells ; Humans ; Apoptosis ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Male ; Lipoproteins, LDL/metabolism ; Efferocytosis
Abstract: In recent years, findings suggest that long noncoding RNAs (lncRNAs) are closely related to the development of atherosclerosis (AS), but there is a lack of studies on the involvement of lncRNA-regulated cytosolic burial in the regulation of AS. In this study, we investigated the mechanism by which lncRNA SCARNA8 affects macrophage cell burial to regulate AS. The cytosolic burial-associated target gene regulated by lncRNA SCARNA8 was PPARG. LncRNA SCARNA8 was increased in the carotid unstable plaque group, whereas PPARG was decreased. Ox-LDL led to the up-regulation of lncRNA SCARNA8 expression and apoptosis in Raw264.7 cells in a time-, concentration-dependent manner. Knockdown of lncRNA SCARNA8 upregulated PPARG and reduced apoptosis in Raw264.7 cells. In addition, knockdown of lncRNA SCARNA8 improved the stability of atherosclerotic plaques by promoting cellular burial of Raw264.7 cells. LncRNA SCARNA8 is a key regulator of plaque vulnerability, and targeting lncRNA SCARNA8 May provide a novel means for the prevention and treatment of AS.
References: Eur Heart J. 2015 Dec 1;36(45):3147-54. (PMID: 26419623)
J Leukoc Biol. 2023 Jan 10;113(1):41-57. (PMID: 36822162)
Prog Lipid Res. 2019 Jan;73:65-91. (PMID: 30528667)
J Clin Invest. 2017 Nov 1;127(11):4075-4089. (PMID: 28972541)
Phytomedicine. 2024 Jan;123:155227. (PMID: 38128398)
Circ Res. 2018 Jan 5;122(1):155-166. (PMID: 29301847)
Lancet. 2013 Oct 19;382(9901):1329-40. (PMID: 23915883)
Circulation. 2017 Sep 19;136(12):1140-1154. (PMID: 28698173)
N Engl J Med. 2017 Sep 21;377(12):1119-1131. (PMID: 28845751)
J Clin Invest. 2018 Jul 2;128(7):2713-2723. (PMID: 30108191)
J Clin Lab Anal. 2020 Feb;34(2):e23056. (PMID: 31721299)
J Cardiovasc Transl Res. 2019 Jun;12(3):171-183. (PMID: 30607799)
Atherosclerosis. 2017 Nov;266:176-181. (PMID: 29035780)
Front Immunol. 2023 Dec 08;14:1301051. (PMID: 38143759)
Biochem Genet. 2024 Aug;62(4):3155-3173. (PMID: 38082058)
Circ Res. 2018 Jul 6;123(2):205-220. (PMID: 29976688)
Circulation. 2017 Jul 18;136(3):263-276. (PMID: 28483812)
J Cell Mol Med. 2023 Dec;27(24):4155-4170. (PMID: 37905351)
Nat Immunol. 2018 Jun;19(6):526-537. (PMID: 29777212)
Vascul Pharmacol. 2019 Mar;114:76-92. (PMID: 30300747)
Acta Pharmacol Sin. 2018 Jul;39(7):1100-1109. (PMID: 29565037)
Circulation. 2017 Jan 31;135(5):476-489. (PMID: 28137963)
Eur Heart J Cardiovasc Imaging. 2019 Feb 1;20(2):168-176. (PMID: 30325426)
Front Immunol. 2019 Jan 29;9:3184. (PMID: 30761161)
Cell. 2018 Jan 25;172(3):393-407. (PMID: 29373828)
Immun Inflamm Dis. 2023 Feb;11(2):e779. (PMID: 36840485)
Nat Rev Dis Primers. 2019 Aug 16;5(1):56. (PMID: 31420554)
Immunity. 2017 Oct 17;47(4):621-634. (PMID: 29045897)
Diabetes Metab Syndr. 2015 Jan-Mar;9(1):46-50. (PMID: 25450819)
Nat Rev Cardiol. 2019 Jul;16(7):389-406. (PMID: 30846875)
Nucleic Acids Res. 2019 Jan 8;47(D1):D140-D144. (PMID: 30380072)
Cell Mol Neurobiol. 2022 Jan;42(1):265-278. (PMID: 32653974)
Circ Res. 2014 Jan 3;114(1):214-26. (PMID: 24385514)
Front Immunol. 2019 Jan 10;9:3127. (PMID: 30687328)
Contributed Indexing: Keywords: Long noncoding RNAs; PPARG; atherosclerosis; macrophage efferocytosis
Substance Nomenclature: 0 (RNA, Long Noncoding)
0 (PPAR gamma)
0 (oxidized low density lipoprotein)
0 (Lipoproteins, LDL)
Entry Date(s): Date Created: 20250513 Date Completed: 20250513 Latest Revision: 20250516
Update Code: 20250519
PubMed Central ID: PMC12077458
DOI: 10.1080/15592294.2025.2487317
PMID: 40356342
Database: MEDLINE
Description
Abstract:In recent years, findings suggest that long noncoding RNAs (lncRNAs) are closely related to the development of atherosclerosis (AS), but there is a lack of studies on the involvement of lncRNA-regulated cytosolic burial in the regulation of AS. In this study, we investigated the mechanism by which lncRNA SCARNA8 affects macrophage cell burial to regulate AS. The cytosolic burial-associated target gene regulated by lncRNA SCARNA8 was PPARG. LncRNA SCARNA8 was increased in the carotid unstable plaque group, whereas PPARG was decreased. Ox-LDL led to the up-regulation of lncRNA SCARNA8 expression and apoptosis in Raw264.7 cells in a time-, concentration-dependent manner. Knockdown of lncRNA SCARNA8 upregulated PPARG and reduced apoptosis in Raw264.7 cells. In addition, knockdown of lncRNA SCARNA8 improved the stability of atherosclerotic plaques by promoting cellular burial of Raw264.7 cells. LncRNA SCARNA8 is a key regulator of plaque vulnerability, and targeting lncRNA SCARNA8 May provide a novel means for the prevention and treatment of AS.
ISSN:1559-2308
DOI:10.1080/15592294.2025.2487317