Epidemiology and pathobiology of H5Nx highly pathogenic avian influenza in South Korea (2003-2024): a comprehensive review.
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| Názov: | Epidemiology and pathobiology of H5Nx highly pathogenic avian influenza in South Korea (2003-2024): a comprehensive review. |
|---|---|
| Autori: | Lee SH; Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.; Wildlife Health Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea., Kwon JH; Laboratory of Veterinary Microbiology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea., Youk S; Department of Microbiology, College of Medicine, Chungbuk National University, Cheongju-si, Republic of Korea., Lee SW; College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea., Lee DH; Wildlife Health Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea., Song CS; Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea. |
| Zdroj: | The veterinary quarterly [Vet Q] 2025 Dec; Vol. 45 (1), pp. 23-38. Date of Electronic Publication: 2025 May 07. |
| Spôsob vydávania: | Journal Article; Review |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 7909485 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-5941 (Electronic) Linking ISSN: 01652176 NLM ISO Abbreviation: Vet Q Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2011->: Abingdon, Oxfordshire : Taylor & Francis Original Publication: The Hague, Boston : Published for the Royal Netherlands Veterinary Assn. by M. Nijhoff. |
| Výrazy zo slovníka MeSH: | Influenza in Birds*/epidemiology , Influenza in Birds*/virology , Influenza in Birds*/transmission , Influenza A virus*/pathogenicity , Influenza A virus*/genetics , Poultry Diseases*/epidemiology , Poultry Diseases*/virology, Animals ; Republic of Korea/epidemiology ; Disease Outbreaks/veterinary ; Animals, Wild/virology ; Birds ; Influenza A Virus, H5N8 Subtype/pathogenicity ; Influenza A Virus, H5N8 Subtype/genetics ; Poultry ; Influenza A Virus, H5N1 Subtype/pathogenicity ; Influenza A Virus, H5N1 Subtype/genetics ; Chickens |
| Abstrakt: | Since their emergence in Guangdong, China, in 1996, Gs/GD H5 highly pathogenic avian influenza viruses (HPAIVs) have diversified into multiple clades, spreading globally through wild bird migrations and causing substantial losses in poultry and wildlife. In South Korea, HPAIVs, including H5N1, H5N8, and H5N6 subtypes, have been repeatedly introduced since 2003. This review examines the epidemiology, genetic characteristics, and pathobiological features of these viruses in South Korea. Outbreaks typically occur between October and December, aligning with the arrival of wintering migratory birds. While outbreaks in poultry farms dominated before 2018, wild bird cases became more prevalent in subsequent years. Seasonal outbreaks in poultry have declined, but large-scale mortality events in wild birds emerged biennially from 2020. Genotypic diversity has increased since 2014 due to reassortment with low pathogenic viruses, with novel genomic traits detected in recent seasons. Infection studies show consistently fatal outcomes in chickens, while high mortality in domestic ducks was observed only with two of the studied strains, despite efficient transmission. Wild bird studies reveal species-specific roles in viral shedding and transmission. This review underscores the dynamic nature of HPAI outbreaks, highlighting the importance of surveillance, biosecurity, and genetic and pathogenicity analyses to mitigate future risks. |
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| Contributed Indexing: | Keywords: Highly pathogenicity avian influenza; characteristics; outbreak; poultry; republic of Korea; wild bird |
| Entry Date(s): | Date Created: 20250507 Date Completed: 20250507 Latest Revision: 20250511 |
| Update Code: | 20250511 |
| PubMed Central ID: | PMC12064103 |
| DOI: | 10.1080/01652176.2025.2498918 |
| PMID: | 40332021 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Since their emergence in Guangdong, China, in 1996, Gs/GD H5 highly pathogenic avian influenza viruses (HPAIVs) have diversified into multiple clades, spreading globally through wild bird migrations and causing substantial losses in poultry and wildlife. In South Korea, HPAIVs, including H5N1, H5N8, and H5N6 subtypes, have been repeatedly introduced since 2003. This review examines the epidemiology, genetic characteristics, and pathobiological features of these viruses in South Korea. Outbreaks typically occur between October and December, aligning with the arrival of wintering migratory birds. While outbreaks in poultry farms dominated before 2018, wild bird cases became more prevalent in subsequent years. Seasonal outbreaks in poultry have declined, but large-scale mortality events in wild birds emerged biennially from 2020. Genotypic diversity has increased since 2014 due to reassortment with low pathogenic viruses, with novel genomic traits detected in recent seasons. Infection studies show consistently fatal outcomes in chickens, while high mortality in domestic ducks was observed only with two of the studied strains, despite efficient transmission. Wild bird studies reveal species-specific roles in viral shedding and transmission. This review underscores the dynamic nature of HPAI outbreaks, highlighting the importance of surveillance, biosecurity, and genetic and pathogenicity analyses to mitigate future risks. |
|---|---|
| ISSN: | 1875-5941 |
| DOI: | 10.1080/01652176.2025.2498918 |