Where is clinical research in radiation oncology going? a snapshot from Lombardy, Italy-a study endorsed by AIRO Lombardia.
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| Názov: | Where is clinical research in radiation oncology going? a snapshot from Lombardy, Italy-a study endorsed by AIRO Lombardia. |
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| Autori: | Zaffaroni M; Department of Radiation Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy., Vincini MG; Department of Radiation Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy. mariagiulia.vincini@ieo.it., Arcangeli S; Department of Radiation Oncology, University of Milan Bicocca, Milan, Italy., Cocchi A; SC Radioterapia, Ospedale Alessandro Manzoni, ASST Lecco, Lecco, Italy.; Radiation Oncology Department, ASST della Valle Olona, Busto Arsizio, Italy., De Stefani A; Radiotherapy Unit, ASST Bergamo Ovest, Treviglio, BG, Italy., Filippi AR; Radiation Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Franceschini D; Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Milan, Italy., Motta M; Department of Radiation Oncology, ASST Papa Giovanni XXIII, Bergamo, Italy., Piccolo F; SC Radioterapia , Ospedale di Circolo e Fondazione Macchi ASST SETTELAGHI, Varese, Italy., Tomasini D; Department of Radiation Oncology, ASST Spedali Civili Di Brescia, Brescia, Italy., Jereczek-Fossa BA; Department of Radiation Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Laudati A; UOC Di Radioterapia Oncologica, ASST Lariana, Ospedale S. Anna, Como, Italy., Alterio D; Department of Radiation Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy. |
| Zdroj: | Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2025 Oct; Vol. 27 (10), pp. 4011-4019. Date of Electronic Publication: 2025 Apr 21. |
| Spôsob vydávania: | Journal Article; Multicenter Study |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Springer Italia Country of Publication: Italy NLM ID: 101247119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1699-3055 (Electronic) Linking ISSN: 1699048X NLM ISO Abbreviation: Clin Transl Oncol Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2010- >: Milan : Springer Italia Original Publication: Barcelona, Spain : Doyma, c2005- |
| Výrazy zo slovníka MeSH: | Radiation Oncology*/statistics & numerical data , Radiation Oncology*/trends , Clinical Trials as Topic*/statistics & numerical data , Research Support as Topic*/statistics & numerical data , Biomedical Research*/statistics & numerical data , Biomedical Research*/trends , Neoplasms*/radiotherapy, Surveys and Questionnaires ; Italy ; Humans ; Databases, Factual |
| Abstrakt: | Competing Interests: Declarations. Conflict of interest: Division of RT IEO received research funding from AIRC (Italian Association for Cancer Research), and Fondazione IEO-CCM (Istituto Europeo di Oncologia-Centro Cardiologico Monzino) (all outside the current project). IEO, the European Institute of Oncology IRCCS, was partially supported by institutional grants from Accuray Inc. and IBA (Ion Beam Applications, Louvain-la-Neuve, Belgium). The sponsors did not play any role in the study design, collection, analysis, and interpretation of data, nor in the writing of the manuscript, nor in the decision to submit the manuscript for publication. The remaining authors declare no conflicts of interest that are relevant to the content of this article. Research involving human participants and/or animals: Not applicable. Consent to participate: Not applicable. Background: The research activity is fundamental to improve knowledge in Medicine. In the setting of clinical oncology, radiotherapy (RT) represents a cornerstone for patients treated with curative intent. Purpose: The aim of this snapshot was to investigate the number and the characteristics of clinical trials currently ongoing in the Lombardy (Italy) RT divisions highlighting involved resources and eventual needs to improve the process of study activation. Methods: In April 2024, a survey composed of two parts, a snapshot of clinical and research activity and a database to report data on ongoing clinical trials, was proposed to the 30 RT centers in Lombardy. The snapshot consisted of 19 short answer questions. Results: A total of 26 (87%) centers answered the survey. The total number of active studies was 161. The median age among principal investigators was 51 years. Most studies were multicentric (61%) national (76%). Among 72 studies with available phase, 43% resulted phase III studies. Fifty-three (33%) studies were sponsored. IRCCS (Istituti di Ricovero e Cura a carattere scientifico) RT have a median of 11 active studies vs versus 6 in non-IRCCS structures. More resources are available in IRCCS centers compared to non-IRCCS: data management service 50% vs 25%, dedicated scientific nurses 20% vs 0%, clinical statistics services 60% vs 25%. The main difficulties in conducting clinical trials were bureaucratic difficulties with ethics committees (5 centers), time constraints (5 centers), and a lack of resources and staff (15 centers). The most frequently (58% of the centers) proposed solution was an increase in resources and staff. Conclusion: While the RT centers in Lombardy demonstrate a commendable commitment to clinical research, disparities in resources and infrastructure remain significantly challenging. (© 2025. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).) |
| References: | Delaney G, Jacob S, Featherstone C, Barton M. The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer. 2005;104:1129–37. https://doi.org/10.1002/cncr.21324 . (PMID: 10.1002/cncr.2132416080176) Baumann M. Clinical research for global needs of radiation oncology. Radiother Oncol. 2024;190:110076. (PMID: 10.1016/j.radonc.2023.11007638157941) Lawler M, Davies L, Oberst S, Oliver K, Eggermont A, Schmutz A, et al. European groundshot-addressing europe’s cancer research challenges: a Lancet oncology commission. Lancet Oncol. 2023;24:e11–56. https://doi.org/10.1016/S1470-2045(22)00540-X . (PMID: 10.1016/S1470-2045(22)00540-X36400101) Park S. Where is clinical research for radiotherapy going? Cross-sectional comparison of past and contemporary phase III clinical trials. Radiat Oncol. 2020. https://doi.org/10.1186/s13014-020-01489-4 . (PMID: 10.1186/s13014-020-01489-4329778087519557) Nikzad N. Analyzing factors associated with clinical trial publication in radiation oncology. Contemp Clin Trials Commun. 2022;29:100978. (PMID: 10.1016/j.conctc.2022.100978360333629399472) Hancock A. Barriers and facilitators to conducting radiotherapy clinical trials: findings from a UK survey. Radiography. 2023;29(2):369–78. (PMID: 10.1016/j.radi.2023.01.00136758382) Kumar G, Chaudhary P, Quinn A, Su D. Barriers for cancer clinical trial enrollment: a qualitative study of the perspectives of healthcare providers. Contemp Clin Trials Commun. 2022;28: 100939. https://doi.org/10.1016/j.conctc.2022.100939 . (PMID: 10.1016/j.conctc.2022.100939357074839189774) Fogel DB. Factors associated with clinical trials that fail and opportunities for improving the likelihood of success: a review. Contemp Clin Trials Commun. 2018;11:156–64. https://doi.org/10.1016/j.conctc.2018.08.001 . (PMID: 10.1016/j.conctc.2018.08.001301124606092479) Edwards MA, Roy S. Academic research in the 21st Century: maintaining scientific integrity in a climate of perverse incentives and hypercompetition. Environ Eng Sci. 2017;34:51–61. https://doi.org/10.1089/ees.2016.0223 . (PMID: 10.1089/ees.2016.0223281158245206685) |
| Contributed Indexing: | Keywords: Clinical research; Cross-sectional study; Radiation oncology; Survey |
| Entry Date(s): | Date Created: 20250420 Date Completed: 20250930 Latest Revision: 20250930 |
| Update Code: | 20250930 |
| DOI: | 10.1007/s12094-025-03919-9 |
| PMID: | 40254696 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declarations. Conflict of interest: Division of RT IEO received research funding from AIRC (Italian Association for Cancer Research), and Fondazione IEO-CCM (Istituto Europeo di Oncologia-Centro Cardiologico Monzino) (all outside the current project). IEO, the European Institute of Oncology IRCCS, was partially supported by institutional grants from Accuray Inc. and IBA (Ion Beam Applications, Louvain-la-Neuve, Belgium). The sponsors did not play any role in the study design, collection, analysis, and interpretation of data, nor in the writing of the manuscript, nor in the decision to submit the manuscript for publication. The remaining authors declare no conflicts of interest that are relevant to the content of this article. Research involving human participants and/or animals: Not applicable. Consent to participate: Not applicable.<br />Background: The research activity is fundamental to improve knowledge in Medicine. In the setting of clinical oncology, radiotherapy (RT) represents a cornerstone for patients treated with curative intent.<br />Purpose: The aim of this snapshot was to investigate the number and the characteristics of clinical trials currently ongoing in the Lombardy (Italy) RT divisions highlighting involved resources and eventual needs to improve the process of study activation.<br />Methods: In April 2024, a survey composed of two parts, a snapshot of clinical and research activity and a database to report data on ongoing clinical trials, was proposed to the 30 RT centers in Lombardy. The snapshot consisted of 19 short answer questions.<br />Results: A total of 26 (87%) centers answered the survey. The total number of active studies was 161. The median age among principal investigators was 51 years. Most studies were multicentric (61%) national (76%). Among 72 studies with available phase, 43% resulted phase III studies. Fifty-three (33%) studies were sponsored. IRCCS (Istituti di Ricovero e Cura a carattere scientifico) RT have a median of 11 active studies vs versus 6 in non-IRCCS structures. More resources are available in IRCCS centers compared to non-IRCCS: data management service 50% vs 25%, dedicated scientific nurses 20% vs 0%, clinical statistics services 60% vs 25%. The main difficulties in conducting clinical trials were bureaucratic difficulties with ethics committees (5 centers), time constraints (5 centers), and a lack of resources and staff (15 centers). The most frequently (58% of the centers) proposed solution was an increase in resources and staff.<br />Conclusion: While the RT centers in Lombardy demonstrate a commendable commitment to clinical research, disparities in resources and infrastructure remain significantly challenging.<br /> (© 2025. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).) |
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| ISSN: | 1699-3055 |
| DOI: | 10.1007/s12094-025-03919-9 |