View in EDS

Neutralizing Antibodies against California Serogroup Orthobunyaviruses in Human Serum Samples, Montana, USA.

Saved in:
Bibliographic Details
Title: Neutralizing Antibodies against California Serogroup Orthobunyaviruses in Human Serum Samples, Montana, USA.
Authors: Woods TA, Johnson SF, Evans AB, Peterson KE
Source: Emerging infectious diseases [Emerg Infect Dis] 2025 Apr; Vol. 31 (4), pp. 699-709.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE
Imprint Name(s): Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-
MeSH Terms: Antibodies, Viral*/blood , Antibodies, Viral*/immunology , Antibodies, Neutralizing*/blood , Antibodies, Neutralizing*/immunology , Encephalitis, California*/epidemiology , Encephalitis, California*/immunology , Encephalitis, California*/virology , Orthobunyavirus*/immunology , Orthobunyavirus*/classification , Bunyaviridae Infections*/epidemiology , Bunyaviridae Infections*/immunology , Bunyaviridae Infections*/virology, Humans ; Montana/epidemiology ; Encephalitis Virus, California/immunology ; Serogroup ; Cross Reactions ; Neutralization Tests ; Female ; Adult ; Male ; Middle Aged
Abstract: Viral encephalitis is often underreported and undiagnosed. To understand the potential causes of viral encephalitis in the state of Montana, USA, we examined the relative incidence of human infections for the California serogroup (CSG) of Orthobunyaviruses by screening random convenience serum samples obtained from different hospitals across Montana. We initially screened deidentified samples for neutralizing antibodies against Jamestown Canyon virus (JCV), a CSG virus that has caused encephalitis in Montana. We then analyzed JCV-positive samples for neutralization of other CSG viruses, and detected neutralizing antibodies against La Crosse virus, California encephalitis virus, and Trivittatus virus. We also found a high level of cross-reactivity, particularly between JCV and California encephalitis virus. Our findings indicate that the relative CSG virus infection rates in humans are quite high, between 21% and 40%. Clinicians should consider CSG viruses in differential diagnosis for cases of encephalitis of unknown etiology in Montana.
References: Viruses. 2019 Aug 29;11(9):. (PMID: 31470541)
Semin Neurol. 2019 Aug;39(4):419-427. (PMID: 31533182)
Microbiol Spectr. 2023 Oct 17;11(5):e0196623. (PMID: 37668403)
Virology. 2017 Dec;512:201-210. (PMID: 28985574)
J Infect Dis. 2024 Nov 22;:. (PMID: 39574290)
Am J Trop Med Hyg. 1991 Sep;45(3):377-82. (PMID: 1928574)
Can Commun Dis Rep. 2015 Jun 04;41(6):117-123. (PMID: 29769943)
Am J Trop Med Hyg. 1966 Mar;15(2):199-204. (PMID: 4379642)
J Med Entomol. 2023 Nov 14;60(6):1230-1241. (PMID: 37862064)
J Am Mosq Control Assoc. 1986 Mar;2(1):73-8. (PMID: 3507473)
Am J Trop Med Hyg. 2015 Aug;93(2):384-9. (PMID: 26033022)
J Wildl Dis. 1988 Apr;24(2):352-5. (PMID: 3373643)
Nat Commun. 2019 Feb 20;10(1):879. (PMID: 30787296)
J Neurovirol. 2016 Jun;22(3):257-60. (PMID: 26903031)
Emerg Microbes Infect. 2015 Jun 10;4:e33. (PMID: 26954882)
Am J Hyg. 1961 May;73:344-9. (PMID: 13688984)
J Am Mosq Control Assoc. 2016 Dec;32(4):326-328. (PMID: 28206866)
Am J Trop Med Hyg. 2019 Feb;100(2):445-451. (PMID: 30526745)
Lancet Infect Dis. 2025 Feb;25(2):166-175. (PMID: 39423838)
Emerg Infect Dis. 2019 Apr;25(4):728-738. (PMID: 30882310)
Am J Trop Med Hyg. 1982 Nov;31(6):1245-51. (PMID: 7149110)
MMWR Morb Mortal Wkly Rep. 2021 Aug 13;70(32):1069-1074. (PMID: 34383731)
Am J Epidemiol. 1965 Mar;81:245-53. (PMID: 14261030)
MMWR Morb Mortal Wkly Rep. 2011 May 27;60(20):652-5. (PMID: 21617630)
Sci Rep. 2021 Aug 12;11(1):16424. (PMID: 34385513)
Zoonoses Res. 1964 Aug;3(3):153-64. (PMID: 5895901)
J Clin Microbiol. 2020 Nov 18;58(12):. (PMID: 32938736)
Open Forum Infect Dis. 2017 Jul 22;4(3):ofx150. (PMID: 28948178)
J Wildl Dis. 2024 Apr 1;60(2):375-387. (PMID: 38345469)
Vector Borne Zoonotic Dis. 2016 Mar;16(3):191-8. (PMID: 26855300)
J Assoc Med Microbiol Infect Dis Can. 2021 Sep 30;6(3):213-220. (PMID: 36337757)
Am J Trop Med Hyg. 1984 Nov;33(6):1218-27. (PMID: 6507732)
Vaccines (Basel). 2024 Jul 18;12(7):. (PMID: 39066430)
Am J Trop Med Hyg. 1975 Nov;24(6 Pt 1):1006-9. (PMID: 1200251)
J Gen Virol. 2017 Sep;98(9):2258-2266. (PMID: 28885138)
J Med Entomol. 2023 Nov 14;60(6):1165-1182. (PMID: 37862102)
MMWR Morb Mortal Wkly Rep. 2022 May 06;71(18):628-632. (PMID: 35511710)
Emerg Infect Dis. 2001 May-Jun;7(3):451-2. (PMID: 11384526)
Contributed Indexing: Keywords: California serogroup; Jamestown Canyon virus; Montana; Orthobunyaviruses; United States; arboviruses; meningitis/encephalitis; mosquitoborne infections; mosquitoes; vector-borne infections; viruses
Substance Nomenclature: 0 (Antibodies, Viral)
0 (Antibodies, Neutralizing)
Entry Date(s): Date Created: 20250325 Date Completed: 20250514 Latest Revision: 20250514
Update Code: 20250515
PubMed Central ID: PMC11950286
DOI: 10.3201/eid3104.241520
PMID: 40133033
Database: MEDLINE
Description
Abstract:Viral encephalitis is often underreported and undiagnosed. To understand the potential causes of viral encephalitis in the state of Montana, USA, we examined the relative incidence of human infections for the California serogroup (CSG) of Orthobunyaviruses by screening random convenience serum samples obtained from different hospitals across Montana. We initially screened deidentified samples for neutralizing antibodies against Jamestown Canyon virus (JCV), a CSG virus that has caused encephalitis in Montana. We then analyzed JCV-positive samples for neutralization of other CSG viruses, and detected neutralizing antibodies against La Crosse virus, California encephalitis virus, and Trivittatus virus. We also found a high level of cross-reactivity, particularly between JCV and California encephalitis virus. Our findings indicate that the relative CSG virus infection rates in humans are quite high, between 21% and 40%. Clinicians should consider CSG viruses in differential diagnosis for cases of encephalitis of unknown etiology in Montana.
ISSN:1080-6059
DOI:10.3201/eid3104.241520