Clinical correlates, lipid metabolic parameters and thyroid hormones are associated with abnormal glucose metabolism in first-episode and drug-naïve major depressive disorder patients with suicide attempts: A large cross-sectional study.
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| Názov: | Clinical correlates, lipid metabolic parameters and thyroid hormones are associated with abnormal glucose metabolism in first-episode and drug-naïve major depressive disorder patients with suicide attempts: A large cross-sectional study. |
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| Autori: | Chen S; Institute of Mental Health, Tianjin Anding Hospital, Tianjin, China., Wang J; Institute of Mental Health, Tianjin Anding Hospital, Tianjin, China., Lang X; Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, China., Zhang XY; Hefei Fourth Peoples Hospital, Anhui Mental Health Center, Affiliated Mental Health Center of Anhui Medical University, Hefei, China. Electronic address: zhangxy@psych.ac.cn. |
| Zdroj: | Journal of affective disorders [J Affect Disord] 2025 Jul 01; Vol. 380, pp. 10-16. Date of Electronic Publication: 2025 Mar 20. |
| Spôsob vydávania: | Journal Article |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| Výrazy zo slovníka MeSH: | Depressive Disorder, Major*/epidemiology , Depressive Disorder, Major*/psychology , Depressive Disorder, Major*/blood , Depressive Disorder, Major*/metabolism , Suicide, Attempted*/psychology , Suicide, Attempted*/statistics & numerical data , Thyroid Hormones*/blood , Blood Glucose*/metabolism , Glucose Metabolism Disorders*/epidemiology , Glucose Metabolism Disorders*/blood , Lipid Metabolism*/physiology, Humans ; Female ; Male ; Cross-Sectional Studies ; Adult ; Middle Aged ; Risk Factors ; Comorbidity ; Young Adult ; Thyrotropin/blood ; Lipids/blood |
| Abstrakt: | Competing Interests: Declaration of competing interest No conflict of interest. Background: The factors associated with glucose disturbances in major depressive disorder (MDD) patients with comorbid suicide attempts remains unclear. To the best of our knowledge, this is the first study with a large sample size to examine risk factors for glucose disturbances, including clinically relevant factors, lipid metabolic parameters, and thyroid hormone levels in first-episode drug-naïve (FEDN) MDD patients with comorbid suicide attempts. Methods: A total of 1718 FEDN MDD patients were enrolled. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) were used to assess the clinical symptoms of the patients. Fasting blood samples were collected and biochemical parameters were measured, including fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), thyroid stimulating hormone (TSH), free thyroxine (FT4, FT3), anti-thyroid autoantibodies (TgAb), and thyroid peroxidase antibody (TPOAb). Statistical analyses were performed using multivariate logistic regression analyses and receptor operating characteristic curves. Results: The prevalence of glucose disturbances was 24 % in MDD patients with comorbid suicide attempts, which was 1.88 times higher than that in MDD patients without suicide attempts (11 %). Among MDD patients with comorbid suicide attempters, compared with patients without glucose disturbances, patients with glucose disturbances had higher mean scores on the HAMA, HAMD and PANSS positive subscale scores, and higher mean levels of TC, TG, TSH, HDL-C, LDL-C, and TPOAb. The combination of HAMA score, HAMD score, PANSS positive subscale score and TSH distinguished between patients with and without glucose disturbances. Conclusions: Our findings suggest a high prevalence of glucose disturbances in FEDN MDD patients with comorbid suicide attempts. Several clinical correlates, lipid metabolism parameters, and thyroid hormone function are associated with glucose disturbances in MDD patients with comorbid suicide attempts. (Copyright © 2025 Elsevier B.V. All rights reserved.) |
| Contributed Indexing: | Keywords: Glucose disturbances; Metabolic parameters; Suicide attempt; Thyroid hormones |
| Substance Nomenclature: | 0 (Thyroid Hormones) 0 (Blood Glucose) 9002-71-5 (Thyrotropin) 0 (Lipids) |
| Entry Date(s): | Date Created: 20250322 Date Completed: 20250425 Latest Revision: 20250425 |
| Update Code: | 20250425 |
| DOI: | 10.1016/j.jad.2025.03.102 |
| PMID: | 40120949 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Competing Interests: Declaration of competing interest No conflict of interest.<br />Background: The factors associated with glucose disturbances in major depressive disorder (MDD) patients with comorbid suicide attempts remains unclear. To the best of our knowledge, this is the first study with a large sample size to examine risk factors for glucose disturbances, including clinically relevant factors, lipid metabolic parameters, and thyroid hormone levels in first-episode drug-naïve (FEDN) MDD patients with comorbid suicide attempts.<br />Methods: A total of 1718 FEDN MDD patients were enrolled. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) were used to assess the clinical symptoms of the patients. Fasting blood samples were collected and biochemical parameters were measured, including fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), thyroid stimulating hormone (TSH), free thyroxine (FT4, FT3), anti-thyroid autoantibodies (TgAb), and thyroid peroxidase antibody (TPOAb). Statistical analyses were performed using multivariate logistic regression analyses and receptor operating characteristic curves.<br />Results: The prevalence of glucose disturbances was 24 % in MDD patients with comorbid suicide attempts, which was 1.88 times higher than that in MDD patients without suicide attempts (11 %). Among MDD patients with comorbid suicide attempters, compared with patients without glucose disturbances, patients with glucose disturbances had higher mean scores on the HAMA, HAMD and PANSS positive subscale scores, and higher mean levels of TC, TG, TSH, HDL-C, LDL-C, and TPOAb. The combination of HAMA score, HAMD score, PANSS positive subscale score and TSH distinguished between patients with and without glucose disturbances.<br />Conclusions: Our findings suggest a high prevalence of glucose disturbances in FEDN MDD patients with comorbid suicide attempts. Several clinical correlates, lipid metabolism parameters, and thyroid hormone function are associated with glucose disturbances in MDD patients with comorbid suicide attempts.<br /> (Copyright © 2025 Elsevier B.V. All rights reserved.) |
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| ISSN: | 1573-2517 |
| DOI: | 10.1016/j.jad.2025.03.102 |