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Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020-2023.

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Bibliographic Details
Title: Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020-2023.
Authors: Chiu CY, Godasi RR, Hughes HR, Servellita V, Foresythe K, Tubati A, Zorn K, Sidhu S, Wilson MR, Bethina SV, Abenroth D, Cheng Y, Grams R, Reese C, Isada C, Thottempudi N
Source: Emerging infectious diseases [Emerg Infect Dis] 2025 Feb; Vol. 31 (2), pp. 215-221.
Publication Type: Case Reports; Journal Article
Language: English
Journal Info: Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE
Imprint Name(s): Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-
MeSH Terms: Bunyaviridae Infections*/virology , Bunyaviridae Infections*/diagnosis , Bunyaviridae Infections*/epidemiology , Encephalitis Virus, California*/genetics , Meningoencephalitis*/virology , Meningoencephalitis*/diagnosis , Meningoencephalitis*/epidemiology , Meningoencephalitis*/etiology, Animals ; Female ; Humans ; Male ; Middle Aged ; Fatal Outcome ; High-Throughput Nucleotide Sequencing ; Phylogeny ; United States/epidemiology
Abstract: We used clinical metagenomic next-generation sequencing of cerebrospinal fluid to investigate bunyavirus infections in 2 immunocompromised patients in the United States who had fatal meningoencephalitis. Potosi virus has been isolated from mosquito vectors and Lone Star virus from tick vectors. These findings highlight the power of metagenomic next-generation sequencing in broad-based, agnostic detection of emerging viral infections that test negative using conventional targeted diagnostic methods.
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Contributed Indexing: Keywords: Aedes albopictus mosquito; Amyblomma americanum tick; LSV; Lone Star virus; POTV; Potosi virus; United States; arboviruses; arthropod-borne viruses; bunyavirus; mNGS; meningitis/encephalitis; meningoencephalitis; metagenomic next-generation sequencing; mosquitoes; ticks; vector-borne infections; viruses
Entry Date(s): Date Created: 20250221 Date Completed: 20250221 Latest Revision: 20250520
Update Code: 20250520
PubMed Central ID: PMC11845157
DOI: 10.3201/eid3102.240831
PMID: 39983710
Database: MEDLINE
Description
Abstract:We used clinical metagenomic next-generation sequencing of cerebrospinal fluid to investigate bunyavirus infections in 2 immunocompromised patients in the United States who had fatal meningoencephalitis. Potosi virus has been isolated from mosquito vectors and Lone Star virus from tick vectors. These findings highlight the power of metagenomic next-generation sequencing in broad-based, agnostic detection of emerging viral infections that test negative using conventional targeted diagnostic methods.
ISSN:1080-6059
DOI:10.3201/eid3102.240831