The significance of antibody to hepatitis B surface antigen in infection and clearance of hepatitis B virus.
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| Názov: | The significance of antibody to hepatitis B surface antigen in infection and clearance of hepatitis B virus. |
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| Autori: | Ding L; Department of General Practice, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Huang J; Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Huang S; Department of General Practice, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Nutrition, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. |
| Zdroj: | Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2025 Dec; Vol. 21 (1), pp. 2445283. Date of Electronic Publication: 2025 Jan 03. |
| Spôsob vydávania: | Journal Article; Review |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Austin, Tex. : Landes Bioscience |
| Výrazy zo slovníka MeSH: | Hepatitis B Surface Antigens*/immunology , Hepatitis B Antibodies*/immunology , Hepatitis B, Chronic*/immunology , Hepatitis B, Chronic*/therapy , Hepatitis B virus*/immunology , Hepatitis B Vaccines*/immunology , Hepatitis B Vaccines*/administration & dosage, Humans ; Antibodies, Neutralizing/immunology ; B-Lymphocytes/immunology |
| Abstrakt: | One of the key features of chronic hepatitis B virus (HBV) infection is the inability to mount sufficient and coordinated adaptive immune responses against HBV. Recent studies on HBV-specific B cells and antibody to hepatitis B surface antigen (anti-HBs) have shed light on their role in the pathogenesis of chronic hepatitis B (CHB). Anti-HBs is recognized as a protective immune marker, both for HBV infection clearance and following vaccination, and it is also considered an important indicator of functional cure for CHB. Notably, functional impairment of HBV-specific B cells may be reversible. The restoration of HBV-specific B cell function, along with the induction of an anti-HBs antibody response, is regarded as pivotal for terminating chronic HBV infection and achieving functional cure. This article reviews the significance of anti-HBs in both the infection and clearance of HBV, and discusses the potential of neutralizing antibodies and therapeutic vaccines as promising future strategies. |
| Contributed Indexing: | Keywords: HBV-specific B cells; Hepatitis B virus; functional cure; hepatitis B surface antibody; therapeutic vaccines |
| Substance Nomenclature: | 0 (Hepatitis B Surface Antigens) 0 (Hepatitis B Antibodies) 0 (Hepatitis B Vaccines) 0 (Antibodies, Neutralizing) |
| Entry Date(s): | Date Created: 20250104 Date Completed: 20250106 Latest Revision: 20250113 |
| Update Code: | 20250113 |
| DOI: | 10.1080/21645515.2024.2445283 |
| PMID: | 39754388 |
| Databáza: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | One of the key features of chronic hepatitis B virus (HBV) infection is the inability to mount sufficient and coordinated adaptive immune responses against HBV. Recent studies on HBV-specific B cells and antibody to hepatitis B surface antigen (anti-HBs) have shed light on their role in the pathogenesis of chronic hepatitis B (CHB). Anti-HBs is recognized as a protective immune marker, both for HBV infection clearance and following vaccination, and it is also considered an important indicator of functional cure for CHB. Notably, functional impairment of HBV-specific B cells may be reversible. The restoration of HBV-specific B cell function, along with the induction of an anti-HBs antibody response, is regarded as pivotal for terminating chronic HBV infection and achieving functional cure. This article reviews the significance of anti-HBs in both the infection and clearance of HBV, and discusses the potential of neutralizing antibodies and therapeutic vaccines as promising future strategies. |
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| ISSN: | 2164-554X |
| DOI: | 10.1080/21645515.2024.2445283 |