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The role and function of lncRNA in ageing-associated liver diseases.

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Title: The role and function of lncRNA in ageing-associated liver diseases.
Authors: Zarandi PK; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.; Cancer Biology Signaling Pathway Interest Group (CBSPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran., Ghiasi M; Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran., Heiat M; Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Baqiyatallah University of Medical Sciences, Tehran, Iran.
Source: RNA biology [RNA Biol] 2025 Dec; Vol. 22 (1), pp. 1-8. Date of Electronic Publication: 2024 Dec 19.
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101235328 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-8584 (Electronic) Linking ISSN: 15476286 NLM ISO Abbreviation: RNA Biol Subsets: MEDLINE
Imprint Name(s): Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Georgetown, TX : Landes Bioscience,
MeSH Terms: RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Aging*/genetics , Liver Diseases*/genetics , Liver Diseases*/metabolism , Liver Diseases*/pathology , Gene Expression Regulation*, Humans ; Animals ; Liver/metabolism ; Liver/pathology ; Apoptosis/genetics ; Cellular Senescence/genetics ; Cell Proliferation
Abstract: Liver diseases are a significant global health issue, characterized by elevated levels of disorder and death. The substantial impact of ageing on liver diseases and their prognosis is evident. Multiple processes are involved in the ageing process, which ultimately leads to functional deterioration of this organ. The process of liver ageing not only renders the liver more susceptible to diseases but also compromises the integrity of other organs due to the liver's critical function in metabolism regulation. A growing body of research suggests that long non-coding RNAs (lncRNAs) play a significant role in the majority of pathophysiological pathways. They regulate gene expression through a variety of interactions with microRNAs (miRNAs), messenger RNAs (mRNAs), DNA, or proteins. LncRNAs exert a major influence on the progression of age-related liver diseases through the regulation of cell proliferation, necrosis, apoptosis, senescence, and metabolic reprogramming. A concise overview of the current understanding of lncRNAs and their potential impact on the development of age-related liver diseases will be provided in this mini-review.
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Contributed Indexing: Keywords: Liver diseases; ageing; liver ageing; lncRNAs; ncRNAs
Substance Nomenclature: 0 (RNA, Long Noncoding)
Entry Date(s): Date Created: 20241219 Date Completed: 20241219 Latest Revision: 20250121
Update Code: 20250122
PubMed Central ID: PMC11660375
DOI: 10.1080/15476286.2024.2440678
PMID: 39697114
Database: MEDLINE
Description
Abstract:Liver diseases are a significant global health issue, characterized by elevated levels of disorder and death. The substantial impact of ageing on liver diseases and their prognosis is evident. Multiple processes are involved in the ageing process, which ultimately leads to functional deterioration of this organ. The process of liver ageing not only renders the liver more susceptible to diseases but also compromises the integrity of other organs due to the liver's critical function in metabolism regulation. A growing body of research suggests that long non-coding RNAs (lncRNAs) play a significant role in the majority of pathophysiological pathways. They regulate gene expression through a variety of interactions with microRNAs (miRNAs), messenger RNAs (mRNAs), DNA, or proteins. LncRNAs exert a major influence on the progression of age-related liver diseases through the regulation of cell proliferation, necrosis, apoptosis, senescence, and metabolic reprogramming. A concise overview of the current understanding of lncRNAs and their potential impact on the development of age-related liver diseases will be provided in this mini-review.
ISSN:1555-8584
DOI:10.1080/15476286.2024.2440678