Multiple social factors are associated with wellbeing when accounting for shared genetic and environmental confounding.
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| Title: | Multiple social factors are associated with wellbeing when accounting for shared genetic and environmental confounding. |
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| Authors: | Bjørndal LD; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway. l.d.bjorndal@psykologi.uio.no., Nes RB; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.; Division of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway.; Department of Philosophy, Classics, and History of Arts and Ideas, University of Oslo, Oslo, Norway., Ayorech Z; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway., Vassend O; Department of Psychology, University of Oslo, Oslo, Norway., Røysamb E; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.; Division of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway. |
| Source: | Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2025 Feb; Vol. 34 (2), pp. 535-545. Date of Electronic Publication: 2024 Nov 20. |
| Publication Type: | Journal Article; Twin Study |
| Language: | English |
| Journal Info: | Publisher: Springer Netherlands Country of Publication: Netherlands NLM ID: 9210257 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2649 (Electronic) Linking ISSN: 09629343 NLM ISO Abbreviation: Qual Life Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2005- : Netherlands : Springer Netherlands Original Publication: Oxford, UK : Rapid Communications of Oxford, Ltd, c1992- |
| MeSH Terms: | Personal Satisfaction* , Mental Health* , Social Factors* , Social Environment* , Quality of Life*, Humans ; Female ; Male ; Adult ; Middle Aged ; Loneliness/psychology ; Trust ; Aged ; Interpersonal Relations ; Young Adult ; Gene-Environment Interaction |
| Abstract: | Competing Interests: Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose. Purpose: Social factors are associated with mental health and wellbeing. However, few studies have examined genetic and environmental influences on social factors themselves, limiting current understanding of influences on aspects of the social environment. Most studies which have identified links between social factors and mental health are also limited by the possible influence of unmeasured genetic and environmental confounding. In this study, we investigated the genetic and environmental underpinnings of multiple social factors (relationship satisfaction, loneliness, attachment, trust, relationship disruptions), and their associations with life satisfaction measured concurrently and six years later, after accounting for shared genetic and environmental confounding. Methods: Data from a population-based sample of adult twins (N = 1987) and two measurement timepoints were used for the primary analyses. We used multivariate Cholesky models to estimate genetic and environmental influences across five social factors. Subsequently, we conducted co-twin control analyses to examine associations between social factors and wellbeing after controlling for shared genetic and environmental confounding. Results: Heritability estimates for the social factors ranged from 24 to 42%. Genetic correlations across social factors were substantial, indicative of considerable genetic overlap. Associations between wellbeing and relationship satisfaction, loneliness, anxious and avoidant attachment, trust, and disruptions in relationships in the past year were attenuated in co-twin control analyses but remained statistically significant. Relationship satisfaction, loneliness, and attachment avoidance were also associated with wellbeing measured six years later in estimates which controlled for shared genetic and environmental confounding. Conclusion: Our findings provide evidence that multiple social factors are associated with wellbeing after accounting for potential confounding by shared genetic and/or environmental factors. These findings highlight the importance of multiple aspects of the social environment for wellbeing in older adulthood. Future studies should examine the directionality in associations between social factors and mental health and assess these relationships beyond older adulthood. (© 2024. The Author(s).) |
| Comments: | Erratum in: Qual Life Res. 2025 Feb;34(2):547. doi: 10.1007/s11136-024-03886-8.. (PMID: 39812962) |
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| Grant Information: | 314843 Norges Forskningsråd; 288083 Norges Forskningsråd |
| Contributed Indexing: | Keywords: Co-twin control; Environmental influences; Genetics; Social factors; Twin study; Wellbeing |
| Entry Date(s): | Date Created: 20241120 Date Completed: 20250226 Latest Revision: 20250522 |
| Update Code: | 20250522 |
| PubMed Central ID: | PMC11865172 |
| DOI: | 10.1007/s11136-024-03832-8 |
| PMID: | 39565552 |
| Database: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstract: | Competing Interests: Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose.<br />Purpose: Social factors are associated with mental health and wellbeing. However, few studies have examined genetic and environmental influences on social factors themselves, limiting current understanding of influences on aspects of the social environment. Most studies which have identified links between social factors and mental health are also limited by the possible influence of unmeasured genetic and environmental confounding. In this study, we investigated the genetic and environmental underpinnings of multiple social factors (relationship satisfaction, loneliness, attachment, trust, relationship disruptions), and their associations with life satisfaction measured concurrently and six years later, after accounting for shared genetic and environmental confounding.<br />Methods: Data from a population-based sample of adult twins (N = 1987) and two measurement timepoints were used for the primary analyses. We used multivariate Cholesky models to estimate genetic and environmental influences across five social factors. Subsequently, we conducted co-twin control analyses to examine associations between social factors and wellbeing after controlling for shared genetic and environmental confounding.<br />Results: Heritability estimates for the social factors ranged from 24 to 42%. Genetic correlations across social factors were substantial, indicative of considerable genetic overlap. Associations between wellbeing and relationship satisfaction, loneliness, anxious and avoidant attachment, trust, and disruptions in relationships in the past year were attenuated in co-twin control analyses but remained statistically significant. Relationship satisfaction, loneliness, and attachment avoidance were also associated with wellbeing measured six years later in estimates which controlled for shared genetic and environmental confounding.<br />Conclusion: Our findings provide evidence that multiple social factors are associated with wellbeing after accounting for potential confounding by shared genetic and/or environmental factors. These findings highlight the importance of multiple aspects of the social environment for wellbeing in older adulthood. Future studies should examine the directionality in associations between social factors and mental health and assess these relationships beyond older adulthood.<br /> (© 2024. The Author(s).) |
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| ISSN: | 1573-2649 |
| DOI: | 10.1007/s11136-024-03832-8 |