High Estradiol Environment After IVF Causes Increased Risk of Glucose Metabolic Dysfunction in Offspring.
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| Názov: | High Estradiol Environment After IVF Causes Increased Risk of Glucose Metabolic Dysfunction in Offspring. |
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| Autori: | Lv PP; The Reproductive Center, Women's Hospital of Zhejiang University School of Medicine, Hangzhou 310006, China.; Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, Zhejiang 310006, China., Feng C; Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, Zhejiang 310006, China.; The Reproductive Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China., Ding GL; Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, Zhejiang 310006, China.; Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200433, China., Yu DQ; The Reproductive Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China., Yan YS; The Reproductive Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China., Liu J; The Reproductive Center, Women's Hospital of Zhejiang University School of Medicine, Hangzhou 310006, China., Lv M; The Reproductive Center, Women's Hospital of Zhejiang University School of Medicine, Hangzhou 310006, China., Ying YY; The Reproductive Center, Women's Hospital of Zhejiang University School of Medicine, Hangzhou 310006, China., Li JY; The Reproductive Center, Women's Hospital of Zhejiang University School of Medicine, Hangzhou 310006, China., Chen XJ; The Reproductive Center, Women's Hospital of Zhejiang University School of Medicine, Hangzhou 310006, China., Ye YH; The Reproductive Center, Women's Hospital of Zhejiang University School of Medicine, Hangzhou 310006, China., Amanda K; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06520, USA., Wu YT; Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200433, China., Huang HF; The Reproductive Center, Women's Hospital of Zhejiang University School of Medicine, Hangzhou 310006, China.; Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, Zhejiang 310006, China.; Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200433, China., Zhang D; The Reproductive Center, Women's Hospital of Zhejiang University School of Medicine, Hangzhou 310006, China.; Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, Zhejiang 310006, China. |
| Zdroj: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2025 May 19; Vol. 110 (6), pp. 1680-1688. |
| Spôsob vydávania: | Journal Article |
| Jazyk: | English |
| Informácie o časopise: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2017- : New York : Oxford University Press Original Publication: Springfield, Ill. : Charles C. Thomas |
| Výrazy zo slovníka MeSH: | Fertilization in Vitro*/adverse effects , Estradiol*/blood , Estradiol*/adverse effects , Prenatal Exposure Delayed Effects*/metabolism , Glucose Metabolism Disorders*/etiology , Glucose Metabolism Disorders*/epidemiology, Female ; Pregnancy ; Humans ; Animals ; Retrospective Studies ; Mice ; Child ; Child, Preschool ; Male ; Insulin Resistance ; Embryo Transfer/adverse effects ; Blood Glucose/metabolism ; Blood Glucose/analysis ; Insulin/blood ; Adult ; Glucose/metabolism |
| Abstrakt: | Context: Assisted reproductive technology (ART) is associated with increased metabolic risks in offspring. The effect of high maternal estradiol (E2) levels during early pregnancy on the glucose metabolism of offspring remains unclear. Objective: This work aimed to evaluate glucose metabolism in children conceived via in vitro fertilization (IVF) and to assess whether high E2 exposure during early pregnancy is associated with metabolic alterations. Methods: This retrospective analysis included 500 singletons aged 3 to 10 years born after fresh embryo transfer (ET) (n = 200), frozen ET (n = 100), and natural conception (NC) (n = 200) from a university hospital. Children underwent anthropometric measurements and examinations for fasting glucose, insulin, and lipid levels. A mouse model of high E2 exposure during early pregnancy was established to study glucose and insulin tolerance, and insulin secretion. Results: Compared with NC, children born after fresh ET showed higher fasting glucose/insulin levels, increased insulin resistance, and higher incidence of impaired fasting glucose, which might be associated with higher maternal E2 levels. Frozen ET showed intermediate results. In mice, offspring exposed to high E2 levels during gestation exhibited impaired glucose/insulin tolerance and defects in insulin secretion. Conclusion: High maternal E2 levels in early pregnancy are associated with altered glucose metabolism and increased metabolic risks in IVF-conceived children. Further studies are needed to elucidate the underlying mechanisms. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. See the journal About page for additional terms.) |
| Grant Information: | LY21H040004 Natural Science Foundation of Zhejiang Province; LY22H040002 Natural Science Foundation of Zhejiang Province; 82171690 National Natural Science Foundation of China; 81901498 National Natural Science Foundation of China; 2021C03G2013079 Key Research and Development Program of Zhejiang; 2021YFC2700701 National Key Research and Development Program of China; 2021YFC2700100 National Key Research and Development Program of China |
| Contributed Indexing: | Keywords: IVF; estradiol; glucose metabolism; insulin resistance; islet; offspring |
| Substance Nomenclature: | 4TI98Z838E (Estradiol) 0 (Blood Glucose) 0 (Insulin) IY9XDZ35W2 (Glucose) |
| Entry Date(s): | Date Created: 20241009 Date Completed: 20250519 Latest Revision: 20250519 |
| Update Code: | 20250519 |
| DOI: | 10.1210/clinem/dgae671 |
| PMID: | 39383320 |
| Databáza: | MEDLINE |
Nájsť tento článok vo Web of Science | Abstrakt: | Context: Assisted reproductive technology (ART) is associated with increased metabolic risks in offspring. The effect of high maternal estradiol (E2) levels during early pregnancy on the glucose metabolism of offspring remains unclear.<br />Objective: This work aimed to evaluate glucose metabolism in children conceived via in vitro fertilization (IVF) and to assess whether high E2 exposure during early pregnancy is associated with metabolic alterations.<br />Methods: This retrospective analysis included 500 singletons aged 3 to 10 years born after fresh embryo transfer (ET) (n = 200), frozen ET (n = 100), and natural conception (NC) (n = 200) from a university hospital. Children underwent anthropometric measurements and examinations for fasting glucose, insulin, and lipid levels. A mouse model of high E2 exposure during early pregnancy was established to study glucose and insulin tolerance, and insulin secretion.<br />Results: Compared with NC, children born after fresh ET showed higher fasting glucose/insulin levels, increased insulin resistance, and higher incidence of impaired fasting glucose, which might be associated with higher maternal E2 levels. Frozen ET showed intermediate results. In mice, offspring exposed to high E2 levels during gestation exhibited impaired glucose/insulin tolerance and defects in insulin secretion.<br />Conclusion: High maternal E2 levels in early pregnancy are associated with altered glucose metabolism and increased metabolic risks in IVF-conceived children. Further studies are needed to elucidate the underlying mechanisms.<br /> (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. See the journal About page for additional terms.) |
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| ISSN: | 1945-7197 |
| DOI: | 10.1210/clinem/dgae671 |