Top-down modulation of visual cortical stimulus encoding and gamma independent of firing rates.
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| Název: | Top-down modulation of visual cortical stimulus encoding and gamma independent of firing rates. |
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| Autoři: | Lewis CM; Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany.; Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Wunderle T; Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany., Fries P; Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany.; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EN Nijmegen, Netherlands. |
| Zdroj: | BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 12. Date of Electronic Publication: 2024 Apr 12. |
| Způsob vydávání: | Preprint; Journal Article |
| Jazyk: | English |
| Informace o časopise: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Abstrakt: | Neurons in primary visual cortex integrate sensory input with signals reflecting the animal's internal state to support flexible behavior. Internal variables, such as expectation, attention, or current goals, are imposed in a top-down manner via extensive feedback projections from higher-order areas. We optogenetically activated a high-order visual area, area 21a, in the lightly anesthetized cat (OptoTD), while recording from neuronal populations in V1. OptoTD induced strong, up to several fold, changes in gamma-band synchronization together with much smaller changes in firing rate, and the two effects showed no correlation. OptoTD effects showed specificity for the features of the simultaneously presented visual stimuli. OptoTD-induced changes in gamma synchronization, but not firing rates, were predictive of simultaneous changes in the amount of encoded stimulus information. Our findings suggest that one important role of top-down signals is to modulate synchronization and the information encoded by populations of sensory neurons. |
| Competing Interests: | Declaration of Interests P.F. and C.M.L. have a patent on implantation methods for thin-film electrodes, and P.F. is member of the Advisory Board of CorTec GmbH (Freiburg, Germany). |
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| Grant Information: | U54 MH091657 United States MH NIMH NIH HHS |
| Contributed Indexing: | Keywords: cortex; feedback; gamma; optogenetics; stimulus decoding; synchronization; top-down; vision |
| Entry Date(s): | Date Created: 20240422 Latest Revision: 20241120 |
| Update Code: | 20250114 |
| PubMed Central ID: | PMC11030389 |
| DOI: | 10.1101/2024.04.11.589006 |
| PMID: | 38645050 |
| Databáze: | MEDLINE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Neurons in primary visual cortex integrate sensory input with signals reflecting the animal's internal state to support flexible behavior. Internal variables, such as expectation, attention, or current goals, are imposed in a top-down manner via extensive feedback projections from higher-order areas. We optogenetically activated a high-order visual area, area 21a, in the lightly anesthetized cat (OptoTD), while recording from neuronal populations in V1. OptoTD induced strong, up to several fold, changes in gamma-band synchronization together with much smaller changes in firing rate, and the two effects showed no correlation. OptoTD effects showed specificity for the features of the simultaneously presented visual stimuli. OptoTD-induced changes in gamma synchronization, but not firing rates, were predictive of simultaneous changes in the amount of encoded stimulus information. Our findings suggest that one important role of top-down signals is to modulate synchronization and the information encoded by populations of sensory neurons. |
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| ISSN: | 2692-8205 |
| DOI: | 10.1101/2024.04.11.589006 |