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Correlation Between Clinical Characteristics and Radionuclide Salivagram Findings in Infants With Congenital Laryngeal Developmental Anomalies.

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Title: Correlation Between Clinical Characteristics and Radionuclide Salivagram Findings in Infants With Congenital Laryngeal Developmental Anomalies.
Authors: Liu Y; Department of Pneumology, Xi'an Children's Hospital, Xi'an, Shaanxi, China., Wang X; Department of Pneumology, Xi'an Children's Hospital, Xi'an, Shaanxi, China., Wang LB; Department of Pneumology, Children's Hospital of Fudan University, Shanghai, China. Electronic address: wanglbc@163.com., Sun XR; Department of Pneumology, Xi'an Children's Hospital, Xi'an, Shaanxi, China. Electronic address: wanglbc@163.com.
Source: Journal of voice : official journal of the Voice Foundation [J Voice] 2025 Nov; Vol. 39 (6), pp. 1597-1603. Date of Electronic Publication: 2023 Oct 06.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 8712262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4588 (Electronic) Linking ISSN: 08921997 NLM ISO Abbreviation: J Voice Subsets: MEDLINE
Imprint Name(s): Publication: 2003- : St. Louis, MO : Mosby
Original Publication: [New York, N.Y.] : Raven Press, 1987-
MeSH Terms: Larynx*/abnormalities , Larynx*/diagnostic imaging , Larynx*/physiopathology , Radionuclide Imaging* , Radiopharmaceuticals*/administration & dosage, Humans ; Retrospective Studies ; Female ; Male ; Infant ; Predictive Value of Tests ; Logistic Models ; Risk Factors ; Infant, Newborn ; Multivariate Analysis ; Odds Ratio
Abstract: Competing Interests: Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Objective: To evaluate the correlation between clinical characteristics and radionuclide salivagram findings in infants with congenital laryngeal developmental anomalies, and determine the clinical characteristics that could predict the positive results of radionuclide salivagram.
Methods: 151 hospitalized infants with congenital laryngeal developmental anomalies were retrospectively included to assess the correlation between positive radionuclide salivagram results and clinical features, and a multivariate logistic regression model was constructed to identify significant correlates that jointly predict positive radionuclide salivagram results.
Results: Positive radionuclide salivagram results were significantly associated with fever, neurological diseases, congenital syndromes, and positive pathogenetic test results in univariate analysis. Positive radionuclide salivagram were significantly associated with fever (odds ratio [OR] = 3.494; 95% confidence interval [CI] 1.414-8.630; P = 0.007), neurological diseases (OR = 3.296; 95% CI 1.335-8.138; P = 0.010), and congenital syndromes (OR = 5.069, 95% CI 1.696-15.154; P = 0.004) in a multivariable logistic regression analysis.
Conclusion: Fever, concurrent neurological diseases, and concurrent congenital syndromes were discovered as clinical factors that could predict positive radionuclide salivagram results and salivary aspiration should be highly suspected in infants with these clinical factors of congenital laryngeal developmental anomalies.
(Copyright © 2025. Published by Elsevier Inc.)
Contributed Indexing: Keywords: Clinical characteristics; Infants; Radionuclide salivagram; Salivary aspiration
Substance Nomenclature: 0 (Radiopharmaceuticals)
Entry Date(s): Date Created: 20231008 Date Completed: 20251129 Latest Revision: 20251129
Update Code: 20251130
DOI: 10.1016/j.jvoice.2023.06.025
PMID: 37806900
Database: MEDLINE
Description
Abstract:Competing Interests: Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br />Objective: To evaluate the correlation between clinical characteristics and radionuclide salivagram findings in infants with congenital laryngeal developmental anomalies, and determine the clinical characteristics that could predict the positive results of radionuclide salivagram.<br />Methods: 151 hospitalized infants with congenital laryngeal developmental anomalies were retrospectively included to assess the correlation between positive radionuclide salivagram results and clinical features, and a multivariate logistic regression model was constructed to identify significant correlates that jointly predict positive radionuclide salivagram results.<br />Results: Positive radionuclide salivagram results were significantly associated with fever, neurological diseases, congenital syndromes, and positive pathogenetic test results in univariate analysis. Positive radionuclide salivagram were significantly associated with fever (odds ratio [OR] = 3.494; 95% confidence interval [CI] 1.414-8.630; P = 0.007), neurological diseases (OR = 3.296; 95% CI 1.335-8.138; P = 0.010), and congenital syndromes (OR = 5.069, 95% CI 1.696-15.154; P = 0.004) in a multivariable logistic regression analysis.<br />Conclusion: Fever, concurrent neurological diseases, and concurrent congenital syndromes were discovered as clinical factors that could predict positive radionuclide salivagram results and salivary aspiration should be highly suspected in infants with these clinical factors of congenital laryngeal developmental anomalies.<br /> (Copyright © 2025. Published by Elsevier Inc.)
ISSN:1873-4588
DOI:10.1016/j.jvoice.2023.06.025