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Synthetic Morphogenesis: introducing IEEE journal readers to programming living mammalian cells to make structures.

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Title: Synthetic Morphogenesis: introducing IEEE journal readers to programming living mammalian cells to make structures.
Authors: Davies JA; Professor of Experimental Anatomy at the University of Edinburgh, UK, and a member of the Centre for Mammalian Synthetic Biology at that University.
Source: Proceedings of the IEEE. Institute of Electrical and Electronics Engineers [Proc IEEE Inst Electr Electron Eng] 2022 May; Vol. 110 (5), pp. 688-707.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Institute of Electrical and Electronics Engineers Country of Publication: United States NLM ID: 9879073 Publication Model: Print Cited Medium: Print ISSN: 0018-9219 (Print) Linking ISSN: 00189219 NLM ISO Abbreviation: Proc IEEE Inst Electr Electron Eng Subsets: PubMed not MEDLINE
Imprint Name(s): Original Publication: [New York, N.Y.] : Institute of Electrical and Electronics Engineers, [1963-
Abstract: Synthetic morphogenesis is a new engineering discipline, in which cells are genetically engineered to make designed shapes and structures. At least in this early phase of the field, devices tend to make use of natural shape-generating processes that operate in embryonic development, but invoke them artificially at times and in orders of a technologist's choosing. This requires construction of genetic control, sequencing and feedback systems that have close parallels to electronic design, which is one reason the field may be of interest to readers of IEEE journals. The other reason is that synthetic morphogenesis allows the construction of two-way interfaces, especially opto-genetic and opto-electronic, between the living and the electronic, allowing unprecedented information flow and control between the two types of 'machine'. This review introduces synthetic morphogenesis, illustrates what has been achieved, drawing parallels wherever possible between biology and electronics, and looks forward to likely next steps and challenges to be overcome.
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Grant Information: BB/M018040/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council
Contributed Indexing: Keywords: Biomedical engineering; Circuits and systems; Construction; Electrooptics; Synthetic biology
Entry Date(s): Date Created: 20230102 Latest Revision: 20250530
Update Code: 20250530
PubMed Central ID: PMC7614003
DOI: 10.1109/JPROC.2021.3137077
PMID: 36590991
Database: MEDLINE
Description
Abstract:Synthetic morphogenesis is a new engineering discipline, in which cells are genetically engineered to make designed shapes and structures. At least in this early phase of the field, devices tend to make use of natural shape-generating processes that operate in embryonic development, but invoke them artificially at times and in orders of a technologist's choosing. This requires construction of genetic control, sequencing and feedback systems that have close parallels to electronic design, which is one reason the field may be of interest to readers of IEEE journals. The other reason is that synthetic morphogenesis allows the construction of two-way interfaces, especially opto-genetic and opto-electronic, between the living and the electronic, allowing unprecedented information flow and control between the two types of 'machine'. This review introduces synthetic morphogenesis, illustrates what has been achieved, drawing parallels wherever possible between biology and electronics, and looks forward to likely next steps and challenges to be overcome.
ISSN:0018-9219
DOI:10.1109/JPROC.2021.3137077