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Sentinel lymph node mapping using ICG fluorescence and cone beam CT - a feasibility study in a rabbit model of oral cancer.

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Název: Sentinel lymph node mapping using ICG fluorescence and cone beam CT - a feasibility study in a rabbit model of oral cancer.
Autoři: Muhanna N; Department of Otolaryngology - Head & Neck Surgery, University of Toronto, Toronto, ON, Canada.; Guided Therapeutics (GTx) Program, TECHNA Institute, University Health Network, 101 College St, Toronto, ON, M5G 1L7, Canada.; Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.; Department of Otolaryngology, Head and Neck and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel., Chan HHL; Guided Therapeutics (GTx) Program, TECHNA Institute, University Health Network, 101 College St, Toronto, ON, M5G 1L7, Canada., Douglas CM; Department of Otolaryngology - Head & Neck Surgery, University of Toronto, Toronto, ON, Canada. Catriona.douglas@uhn.ca.; Guided Therapeutics (GTx) Program, TECHNA Institute, University Health Network, 101 College St, Toronto, ON, M5G 1L7, Canada. Catriona.douglas@uhn.ca.; Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada. Catriona.douglas@uhn.ca., Daly MJ; Guided Therapeutics (GTx) Program, TECHNA Institute, University Health Network, 101 College St, Toronto, ON, M5G 1L7, Canada., Jaidka A; Guided Therapeutics (GTx) Program, TECHNA Institute, University Health Network, 101 College St, Toronto, ON, M5G 1L7, Canada., Eu D; Department of Otolaryngology - Head & Neck Surgery, University of Toronto, Toronto, ON, Canada.; Guided Therapeutics (GTx) Program, TECHNA Institute, University Health Network, 101 College St, Toronto, ON, M5G 1L7, Canada., Bernstein J; Department of Otolaryngology - Head & Neck Surgery, University of Toronto, Toronto, ON, Canada.; Guided Therapeutics (GTx) Program, TECHNA Institute, University Health Network, 101 College St, Toronto, ON, M5G 1L7, Canada.; Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada., Townson JL; Guided Therapeutics (GTx) Program, TECHNA Institute, University Health Network, 101 College St, Toronto, ON, M5G 1L7, Canada., Irish JC; Department of Otolaryngology - Head & Neck Surgery, University of Toronto, Toronto, ON, Canada.; Guided Therapeutics (GTx) Program, TECHNA Institute, University Health Network, 101 College St, Toronto, ON, M5G 1L7, Canada.; Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Zdroj: BMC medical imaging [BMC Med Imaging] 2020 Sep 14; Vol. 20 (1), pp. 106. Date of Electronic Publication: 2020 Sep 14.
Způsob vydávání: Journal Article; Research Support, Non-U.S. Gov't
Jazyk: English
Informace o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 100968553 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2342 (Electronic) Linking ISSN: 14712342 NLM ISO Abbreviation: BMC Med Imaging Subsets: MEDLINE
Imprint Name(s): Original Publication: London : BioMed Central, [2001-
Výrazy ze slovníku MeSH: Cone-Beam Computed Tomography/*methods , Indocyanine Green/*administration & dosage , Lymphatic Metastasis/*diagnostic imaging , Mouth Neoplasms/*surgery , Optical Imaging/*methods , Sentinel Lymph Node/*diagnostic imaging , Squamous Cell Carcinoma of Head and Neck/*surgery, Animals ; Cell Line, Tumor ; Feasibility Studies ; Humans ; Male ; Mouth Neoplasms/diagnostic imaging ; Mouth Neoplasms/pathology ; Neoplasm Transplantation ; Prospective Studies ; Rabbits ; Radiography, Interventional ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node Biopsy ; Squamous Cell Carcinoma of Head and Neck/diagnostic imaging ; Squamous Cell Carcinoma of Head and Neck/pathology ; X-Ray Microtomography
Abstrakt: Background: Current sentinel lymph node biopsy (SLNB) techniques, including use of radioisotopes, have disadvantages including the use of a radioactive tracer. Indocyanine green (ICG) based near-infrared (NIR) fluorescence imaging and cone beam CT (CBCT) have advantages for intraoperative use. However, limited literature exists regarding their use in head and neck cancer SLNB.
Methods: This was a prospective, non-randomized study using a rabbit oral cavity VX2 squamous cell carcinoma model (n = 10) which develops lymph node metastasis. Pre-operatively, images were acquired by MicroCT. During surgery, CBCT and NIR fluorescence imaging of ICG was used to map and guide the SLNB resection.
Results: Intraoperative use of ICG to guide fluorescence resection resulted in identification of all lymph nodes identified by pre-operative CT. CBCT was useful for near real time intraoperative imaging and 3D reconstruction.
Conclusions: This pre-clinical study further demonstrates the technical feasibility, limitations and advantages of intraoperative NIR-guided ICG imaging for SLN identification as a complementary method during head and neck surgery.
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Grant Information: . International Princess Margaret Cancer Foundation
Contributed Indexing: Keywords: Cone beam CT; Head and neck cancer; Head and neck surgery; Indocyanine green; Near-infrared fluorescence imaging; Sentinel lymph node biopsy
Substance Nomenclature: IX6J1063HV (Indocyanine Green)
Entry Date(s): Date Created: 20200915 Date Completed: 20210831 Latest Revision: 20240329
Update Code: 20250114
PubMed Central ID: PMC7491106
DOI: 10.1186/s12880-020-00507-x
PMID: 32928138
Databáze: MEDLINE
Popis
Abstrakt:Background: Current sentinel lymph node biopsy (SLNB) techniques, including use of radioisotopes, have disadvantages including the use of a radioactive tracer. Indocyanine green (ICG) based near-infrared (NIR) fluorescence imaging and cone beam CT (CBCT) have advantages for intraoperative use. However, limited literature exists regarding their use in head and neck cancer SLNB.<br />Methods: This was a prospective, non-randomized study using a rabbit oral cavity VX2 squamous cell carcinoma model (n = 10) which develops lymph node metastasis. Pre-operatively, images were acquired by MicroCT. During surgery, CBCT and NIR fluorescence imaging of ICG was used to map and guide the SLNB resection.<br />Results: Intraoperative use of ICG to guide fluorescence resection resulted in identification of all lymph nodes identified by pre-operative CT. CBCT was useful for near real time intraoperative imaging and 3D reconstruction.<br />Conclusions: This pre-clinical study further demonstrates the technical feasibility, limitations and advantages of intraoperative NIR-guided ICG imaging for SLN identification as a complementary method during head and neck surgery.
ISSN:1471-2342
DOI:10.1186/s12880-020-00507-x