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| Názov: |
New aporphine alkaloids with antitumor activities from the roots of Thalictrum omeiense. |
| Autori: |
Chen, Zhao-Jing1 (AUTHOR), Yang, Han-Gao1 (AUTHOR), Zhu, Wen-Peng1 (AUTHOR), Xue, Chun-Mei1 (AUTHOR), Zhang, Hong-Mei1 (AUTHOR), Peng, Yu-Ting1 (AUTHOR), Li, Da-Hong1,2,3 (AUTHOR) lidahong0203@163.com, Hua, Hui-Ming1,3 (AUTHOR) huimhua@163.com |
| Zdroj: |
Journal of Asian Natural Products Research. Dec2025, Vol. 27 Issue 12, p1777-1785. 9p. |
| Predmety: |
*IN vitro studies, *STATISTICAL correlation, *ALKALOIDS, *NUCLEAR magnetic resonance spectroscopy, *RESEARCH funding, *ANTINEOPLASTIC agents, *BREAST tumors, *CELL proliferation, *PLANT roots, *PHYTOCHEMICALS, *CARCINOMA, *DESCRIPTIVE statistics, *PLANT extracts, *CELL lines, *EXPERIMENTAL design, *MEDICINAL plants, *LUNG tumors, *MOLECULAR structure, *RESEARCH, *ANALYTICAL chemistry, *CRYSTALLOGRAPHY, *DRUG discovery, *PHARMACODYNAMICS |
| Abstrakt: |
Two new aporphine alkaloids, 6aR-2'-(3-oxobutenyl)-thaliadin (1) and N-methylthalisopynine (2), along with ten known analogs (3–12), were isolated from the roots of Thalictrum omeiense W. T. Wang et S. H. Wang. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compounds 1–7 and 9–12 were tested for their antiproliferative effects in vitro against two human cancer cell lines (A549 and MCF-7). Among them, compounds 1, 3, and 7 exhibited moderate inhibitory activity against the tested cell lines with IC50 values ranging from 23.73 to 34.97 μM. [ABSTRACT FROM AUTHOR] |
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