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Coumarins and flavones with anti-inflammatory activity isolated from the branches and leaves of Daphne retusa.

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Bibliographic Details
Title: Coumarins and flavones with anti-inflammatory activity isolated from the branches and leaves of Daphne retusa.
Authors: Xu, Yang1 (AUTHOR), Li, Yu-Xia1 (AUTHOR), Sa, Kui-Ru1 (AUTHOR), Sun, De-Juan1 (AUTHOR), Li, Hua1,2 (AUTHOR) 2022041@fjtcm.edu.cn, Chen, Li-Xia1 (AUTHOR) syzyclx@163.com
Source: Journal of Asian Natural Products Research. Dec2025, Vol. 27 Issue 12, p1766-1776. 11p.
Subject Terms: *ANTI-inflammatory agents, *IN vitro studies, *COMPUTER-assisted molecular modeling, *RESEARCH funding, *PHYTOCHEMICALS, *DESCRIPTIVE statistics, *PLANT extracts, *FLAVONES, *MEDICINAL plants, *MOLECULAR structure, *MASS spectrometry, *LEAVES, *CHROMATOGRAPHIC analysis
Abstract: In this study, two new (1, 13) and fourteen known (2–12, 14–16) compounds were isolated from the branches and leaves of Daphne retusa. On the basis of chemical evidence and spectral data analysis (UV, ECD NMR, and HR-ESI-MS), the structures of new compounds were elucidated. Furthermore, all compounds have been tested for their inhibitory effects on NO production in LPS-induced RAW 264.7 cells, and compound 3 showed obvious inhibitory effect. Through target screening and molecular docking technology, potential binding targets for compound 3 to exert anti-inflammatory effects have been predicted. [ABSTRACT FROM AUTHOR]
Database: Academic Search Index
Description
Abstract:In this study, two new (1, 13) and fourteen known (2–12, 14–16) compounds were isolated from the branches and leaves of Daphne retusa. On the basis of chemical evidence and spectral data analysis (UV, ECD NMR, and HR-ESI-MS), the structures of new compounds were elucidated. Furthermore, all compounds have been tested for their inhibitory effects on NO production in LPS-induced RAW 264.7 cells, and compound 3 showed obvious inhibitory effect. Through target screening and molecular docking technology, potential binding targets for compound 3 to exert anti-inflammatory effects have been predicted. [ABSTRACT FROM AUTHOR]
ISSN:10286020
DOI:10.1080/10286020.2024.2315212