Novel drug delivery based on ZnMgO2 nanoparticles loaded with insulin for treating experimental diabetes.
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| Titel: | Novel drug delivery based on ZnMgO2 nanoparticles loaded with insulin for treating experimental diabetes. |
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| Autoren: | AL-Iedani, Hanan Sajjad1 (AUTHOR) hiedani@uowasit.edu.iq, Al-Maamori, Jafar Abass Issa2 (AUTHOR) jalmaamori@uowasit.edu.iq, Rheima, Ahmed Mahdi3 (AUTHOR) ahmed.rheima@gmail.com |
| Quelle: | AIP Conference Proceedings. 2025, Vol. 3190 Issue 1, p1-10. 10p. |
| Schlagwörter: | *INSULIN, *METAL nanoparticles, *SCIENTIFIC method, *NANOSTRUCTURED materials, *INSULIN therapy, *DRUG delivery systems, *METALLIC oxides, *HYPOGLYCEMIC agents |
| Abstract: | In recent years, nanomaterials, and particularly their uses in medicine, have garnered an increasing amount of attention. Nanoparticles made of zinc oxide and magnesium oxide are among the most important types of metal oxides due to the stability of their structures, the low toxicity of their compounds, and the fact that they preserve the structures of cells. One of the most important uses for nanoparticles made of metal oxide is in the medical field, namely in medication delivery. Random selection was used to split twenty-four male albino rats into four groups (n = 6): a control group, an insulin group, diabetic rats, and diabetic rats treated with ZnMgO2 NPs loaded with insulin. Therapy was administered to rats for a period of 28 days. Alloxan was injected intraperitoneally at a dose of 120 mg/kg into rats with blood sugar levels were more than 250 mg/dL. This procedure was used to develop diabetes mellitus. The physicochemical characteristics of the nanoparticles were examined using several analytical methods, such as UV-Vis spectral analysis, X-ray diffraction (XRD), and Field Emission Scanning Electron Microscopy (FE-SEM). The data revealed significant increases in glucose, Hba1c, C-reactive protein, cholesterol, triglyceride, ALP, ALT, and AST levels, as well as a notable decrease in body weight and HDL levels, in the diabetes control group in comparison to the healthy control group, where the difference was statistically significant (P<0.05). Compared to control groups, ZnMgO2 NPs loaded with insulin lower total glucose, Hba1c, C-reactive protein, cholesterol, triglycerides, ALP, ALT, and AST and increase body weight and HDL. Our research found that novel photo-synthesized ZnMgO2 -NPs loaded with insulin had significant antidiabetic effects compared to diabetic rats groups. [ABSTRACT FROM AUTHOR] |
| Datenbank: | Academic Search Index |
Nájsť tento článok vo Web of Science | Abstract: | In recent years, nanomaterials, and particularly their uses in medicine, have garnered an increasing amount of attention. Nanoparticles made of zinc oxide and magnesium oxide are among the most important types of metal oxides due to the stability of their structures, the low toxicity of their compounds, and the fact that they preserve the structures of cells. One of the most important uses for nanoparticles made of metal oxide is in the medical field, namely in medication delivery. Random selection was used to split twenty-four male albino rats into four groups (n = 6): a control group, an insulin group, diabetic rats, and diabetic rats treated with ZnMgO2 NPs loaded with insulin. Therapy was administered to rats for a period of 28 days. Alloxan was injected intraperitoneally at a dose of 120 mg/kg into rats with blood sugar levels were more than 250 mg/dL. This procedure was used to develop diabetes mellitus. The physicochemical characteristics of the nanoparticles were examined using several analytical methods, such as UV-Vis spectral analysis, X-ray diffraction (XRD), and Field Emission Scanning Electron Microscopy (FE-SEM). The data revealed significant increases in glucose, Hba1c, C-reactive protein, cholesterol, triglyceride, ALP, ALT, and AST levels, as well as a notable decrease in body weight and HDL levels, in the diabetes control group in comparison to the healthy control group, where the difference was statistically significant (P<0.05). Compared to control groups, ZnMgO2 NPs loaded with insulin lower total glucose, Hba1c, C-reactive protein, cholesterol, triglycerides, ALP, ALT, and AST and increase body weight and HDL. Our research found that novel photo-synthesized ZnMgO2 -NPs loaded with insulin had significant antidiabetic effects compared to diabetic rats groups. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 0094243X |
| DOI: | 10.1063/5.0293113 |