Zobraziť v EDS

锐扶刀联合重组人干扰素治疗宫颈高级别鳞状上皮内病变 合并人乳头瘤病毒感染的临床疗效研究.

Uložené v:
Podrobná bibliografia
Názov: 锐扶刀联合重组人干扰素治疗宫颈高级别鳞状上皮内病变 合并人乳头瘤病毒感染的临床疗效研究.
Alternate Title: Clinical efficacy study of radio-frequency combined with recombinant human interferon in the treatment of high-grade squamous intraepithelial lesions of the cervix combined with human papillomavirus infection.
Autori: 张胜男1, 张鸿升1 148904176@qq.com, 金 芬1, 郭伟堃1
Zdroj: Journal of Modern Medicine & Health. 8/25/2025, Vol. 41 Issue 8, p1784-1792. 5p.
Predmety: *HUMAN papillomavirus, *SURGICAL blood loss, *STATISTICAL significance, *TUMOR proteins, *TREATMENT effectiveness, *RADIO frequency therapy
Abstract (English): Objective To explore the clinical efficacy of radiofrequency (RF) knife combined with recombinant human interferon in the treatment of highgrade squamous intraepithelial lesions (HSIL) of the cervix with human papillomavirus (HPV) infection. Methods A total of 60 patients with cervical HSIL complicated with HPV infection who were treated in the gynecological clinic of our hospital from July 2023 to June 2024 were randomly divided into observation group and control group using the random number method, with 30 cases in each group. The control group received cervical loop electrosurgical excision procedure (LEEP) combined with recombinant human interferon therapy, while the observation group received radiofrequency (RF) therapy combined with recombinant human interferon therapy. Statistical analysis was conducted on postoperative indicators. HPV clearance rates, and adverse reaction incidence rates in both groups following treatment. Results The rate of vaginal itching, surgery duration, intraoperative blood loss and margin thickness were significantly better than those in the control group, with statistically significant differences (P< 0.05). However, there were no statistically significant differences between the two groups in terms of the concordance rate of cervical tissue pathology before and after surgery, margin positivity rate. HPV seroconversion status, recurrence rate within six months, incidence rate of lower abdomind, and levels of Creactive protein. tumor necrosis factora, and interleukin10 (P > 0.05) . Conclusion The treatment regimen of RF combined with recombinant human interferon for cervical HSIL combined with HPV infection can significantly reduce surgical time and intraoperative blood loss. At the same time, it can also reduce adverse reactions in patients and improve their prognosis. [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 目的 探讨锐扶刀 (RF) 联合重组人干扰素治疗宫颈高级别鳞状上皮内病变 (HSIL) 合并人乳 头瘤病毒 (HPV) 感染的临床疗效。方法 选取 2023 年 7 月至 2024 年 6 月该院妇科门诊就诊的宫颈 HSIL 合 并 HPV 感染患者 60 例, 采用随机数字法分为观察组和对照组, 每组 30 例。对照组给予宫颈环形电切术联合 重组人干扰素治疗, 观察组给予 RF 联合重组人干扰素治疗。对 2 组患者治疗后围术期指标、HPV 转阴率、不 良反应发生率进行统计分析。结果 观察组患者阴道瘙痒发生率、手术时间、术中出血量、切缘厚度均明显均 优于对照组, 差异均有统计学意义 (P<0.05); 2 组患者手术前后宫颈组织病理相符率、切缘阳性率、HPV 转阴 情况、半年内复发率、下腹坠胀发生率, 以及 C 反应蛋白、肿瘤坏死因子-α、白细胞介素-10 水平比较, 差异均无 统计学意义 (P>0.05)。结论 RF 联合重组人干扰素的治疗方案针对宫颈 HSIL 合并 HPV 感染能明显减少 手术时间和术中出血量, 同时, 还能减少患者不良反应, 并改善其预后。 [ABSTRACT FROM AUTHOR]
Databáza: Academic Search Index
Popis
Abstrakt:Objective To explore the clinical efficacy of radiofrequency (RF) knife combined with recombinant human interferon in the treatment of highgrade squamous intraepithelial lesions (HSIL) of the cervix with human papillomavirus (HPV) infection. Methods A total of 60 patients with cervical HSIL complicated with HPV infection who were treated in the gynecological clinic of our hospital from July 2023 to June 2024 were randomly divided into observation group and control group using the random number method, with 30 cases in each group. The control group received cervical loop electrosurgical excision procedure (LEEP) combined with recombinant human interferon therapy, while the observation group received radiofrequency (RF) therapy combined with recombinant human interferon therapy. Statistical analysis was conducted on postoperative indicators. HPV clearance rates, and adverse reaction incidence rates in both groups following treatment. Results The rate of vaginal itching, surgery duration, intraoperative blood loss and margin thickness were significantly better than those in the control group, with statistically significant differences (P< 0.05). However, there were no statistically significant differences between the two groups in terms of the concordance rate of cervical tissue pathology before and after surgery, margin positivity rate. HPV seroconversion status, recurrence rate within six months, incidence rate of lower abdomind, and levels of Creactive protein. tumor necrosis factora, and interleukin10 (P > 0.05) . Conclusion The treatment regimen of RF combined with recombinant human interferon for cervical HSIL combined with HPV infection can significantly reduce surgical time and intraoperative blood loss. At the same time, it can also reduce adverse reactions in patients and improve their prognosis. [ABSTRACT FROM AUTHOR]
ISSN:10095519
DOI:10.3969/j.issn.1009-5519.2025.08.002