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基于 R 语言的国家知识产权局专利数据库中药复方 治疗注意缺陷多动障碍组方规律分析.

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Title: 基于 R 语言的国家知识产权局专利数据库中药复方 治疗注意缺陷多动障碍组方规律分析.
Alternate Title: Analysis of composition patterns in Chinese herbal formulas for treating ADHD based on the patent database of the CNIPA using R language.
Authors: 高泽宏1 gothere@qq.com, 关丽君2 13940599463@139.com
Source: Shandong Medical Journal. 7/25/2025, Vol. 65 Issue 7, p41-45. 5p.
Subject Terms: *ATTENTION-deficit hyperactivity disorder, *PATENT databases, *HERBAL medicine, *CLUSTER analysis (Statistics), *INTELLECTUAL property
Abstract (English): Objective To investigate the composition patterns of Chinese herbal formulas for treating attention deficit hyperactivity disorder (ADHD) in the patent database of the China National Intellectual Property Administration (CNIPA) using R language, and to provide ideas for the treatment of ADHD. Methods Patents meeting inclusion criteria for ADHD herbal formulas were collected from the CNIPA database up to December 2024. R language was employed to analyze prescription data regarding herbal properties, flavors, meridian tropisms, efficacy categories, association rules, and cluster analysis, aiming to uncover patterns in ADHD treatment. Results Totally 110 patent formulas met the criteria, involving 138 distinct herbs with a total frequency of 796 applications. The top three most frequently used herbs were Shichangpu (Acorus tatarinowii), Yuanzhi (Polygalae Radix), and Fuling (Poria). Tonic and tranquilizing herbs were the most common efficacy categories. Herbs with neutral and warm properties, and sweet or pungent flavors, were most commonly employed. Primary meridian tropisms were the heart, liver, kidney, lung, and spleen meridians. Common herb combinations included Shu Dihuang (prepared Rehmanniae Radix Praeparata), Yuanzhi, and Shichangpu and so on. Cluster analysis yielded the three following groups: phlegm-resolving and yin-nourishing herbs [e. g., Shu Dihuang, Wuweizi (Schisandrae Chinensis Fructus), Fuling, Shichangpu], liver-soothing and wind-extinguishing herbs [e. g., Shouwuteng (Polygoni Multiflori Caulis), Baishao (Paeoniae Radix Alba)], and harmonizing and tonifying herbs [e. g., Chaihu (Bupleuri Radix), Renshen (Ginseng Radix et Rhizoma)]. Conclusions The Chinese herbs commonly used for treating ADHD are Shichangpu, Yuanzhi, and Fuling. Tonifying and tranquilizing herbs were predominant. Herbs with neutral or warm properties and sweet or pungent flavors were favored. Association rule analysis identified Shichangpu and Yuanzhi as core herbs. Three groups were obtained by cluster analysis. [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 目的　分析基于 R语言的国家知识产权局专利数据库中药复方治疗注意缺陷多动障碍 (ADHD) 组方规 律, 为 ADHD 的治疗提供思路。方法　收集截止 2024 年12 月的国家知识产权局专利数据库中符合的治疗 ADHD 的 专利中药复方, 基于R语言对处方数据进行性味归经、功效、关联规则分析和聚类分析, 挖掘中药复方治疗 ADHD 的 规律。结果　根据纳入标准, 共纳入 110条专利中药复方, 得到 138味中药, 总用药频数为 796, 频次最多的前三位 药分别为石菖蒲、远志、茯苓; 高频功效药物为补益药、安神药; 平性、温性药和甘、辛味药使用最多; 归经主要为心 经、肝经、肾经、肺经和脾经为主; 常用的药物组合有熟地黄、远志、石菖蒲等, 聚类分析得出以下药物组合, 第一类为 熟地黄、五味子、茯苓、石菖蒲等豁痰养阴类中药, 第二类组合包括首乌藤、白芍等柔肝息风类中药, 第三类组合包括 柴胡、人参等和解补益作用的中药。结论　治疗 ADHD 应用较多的中药为石菖蒲、远志、茯苓, 常用补益药、安神药, 药性以平、温为主, 药味以甘、辛为主, 石菖蒲和远志为中心药物, 药物的聚类分析共得到3类药物组合. [ABSTRACT FROM AUTHOR]
Database: Academic Search Index
Description
Abstract:Objective To investigate the composition patterns of Chinese herbal formulas for treating attention deficit hyperactivity disorder (ADHD) in the patent database of the China National Intellectual Property Administration (CNIPA) using R language, and to provide ideas for the treatment of ADHD. Methods Patents meeting inclusion criteria for ADHD herbal formulas were collected from the CNIPA database up to December 2024. R language was employed to analyze prescription data regarding herbal properties, flavors, meridian tropisms, efficacy categories, association rules, and cluster analysis, aiming to uncover patterns in ADHD treatment. Results Totally 110 patent formulas met the criteria, involving 138 distinct herbs with a total frequency of 796 applications. The top three most frequently used herbs were Shichangpu (Acorus tatarinowii), Yuanzhi (Polygalae Radix), and Fuling (Poria). Tonic and tranquilizing herbs were the most common efficacy categories. Herbs with neutral and warm properties, and sweet or pungent flavors, were most commonly employed. Primary meridian tropisms were the heart, liver, kidney, lung, and spleen meridians. Common herb combinations included Shu Dihuang (prepared Rehmanniae Radix Praeparata), Yuanzhi, and Shichangpu and so on. Cluster analysis yielded the three following groups: phlegm-resolving and yin-nourishing herbs [e. g., Shu Dihuang, Wuweizi (Schisandrae Chinensis Fructus), Fuling, Shichangpu], liver-soothing and wind-extinguishing herbs [e. g., Shouwuteng (Polygoni Multiflori Caulis), Baishao (Paeoniae Radix Alba)], and harmonizing and tonifying herbs [e. g., Chaihu (Bupleuri Radix), Renshen (Ginseng Radix et Rhizoma)]. Conclusions The Chinese herbs commonly used for treating ADHD are Shichangpu, Yuanzhi, and Fuling. Tonifying and tranquilizing herbs were predominant. Herbs with neutral or warm properties and sweet or pungent flavors were favored. Association rule analysis identified Shichangpu and Yuanzhi as core herbs. Three groups were obtained by cluster analysis. [ABSTRACT FROM AUTHOR]
ISSN:1002266X
DOI:10.3969/j.issn.1002-266X.2025.07.010