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基于 国 家 专 利 的 中 药 复 方 治 疗 三 叉 神 经 痛 的 数据挖掘研究.

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Titel: 基于 国 家 专 利 的 中 药 复 方 治 疗 三 叉 神 经 痛 的 数据挖掘研究.
Alternate Title: Data Mining on Traditional Chinese Medicine Compound Formulated from National Patents in the Treatment of Trigeminal Neuralgia.
Autoren: 李相国1 664350119@qq.com, 黄德斌2, 杨 柳1 174169217@qq.com
Quelle: Evaluation & Analysis of Drug-Use in Hospitals of China / Zhongguo Yiyuan Yongyao Pingjia yu Fenxi. 2025, Vol. 25 Issue 4, p385-393. 5p.
Schlagwörter: *CHINESE medicine, *PATENT databases, *TRIGEMINAL neuralgia, *DRUG development, *CLUSTER analysis (Statistics)
Abstract (English): OBJECTIVE: To analyze the medication patterns of traditional Chinese medicine compound patents in the treatment of trigeminal neuralgia, so as to provide reference for the research and development of new prescriptions. METHODS: Prescription data of traditional Chinese medicine for trigeminal neuralgia in the national patent database were retrieved (search time was from database establishment to Sept. 30th, 2024), and Excel 2021 was used to perform statistics on flavors and frequency, R 4. 3. 3 software was used for the analysis of association rules, clustering, and correlation coefficients. The core complex network of traditional Chinese medicine was constructed by Cytoscape 3. 8, and the dense clusters of traditional Chinese medicine were extracted. RESULTS: A total of 171 patents were enrolled, including 609 flavors of medicines. The top 4 high-frequency medicines were Chuanxiong rhizoma, licorice, Buthus martensi, and Radix angelicae dahuricae. The medicinal properties were mainly cold, followed by warm. The medicinal flavors were bitter, followed by pungent and sweet. The top 3 meridians were liver meridian, lung meridian, and stomach meridian. The commonly used pairs of drugs were Radix angelicae dahuricae-Chuanxiong rhizoma, Scolopendra subspinipes mutilans-Buthus martensi, Bombyx Batryticatus-Buthus martensi, with the combinations including Radix angelicae dahuricae-Buthus martensi-Chuanxiong rhizoma, licorice, Scolopendra subspinipes mutilansChuanxiong rhizoma-Buthus martensi, Bombyx Batryticatus-Buthus martensi-Chuanxiong rhizoma. Four groups of core drug combinations were extracted by complex cluster analysis, and two potential drug combinations were identified. CONCLUSIONS: Traditional Chinese medicine compound patents in the treatment of trigeminal neuralgia are based on dispelling wind and relieving pain as the basic rule of treatment. The medication patterns and potential drug combinations obtained can lay a foundation for guiding clinical drug use and new drug development [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 目的: 探讨中药复方专利治疗三叉神经痛的用药规律, 为新方研发提供参考。 方法: 检索国家专利数据库中治疗三叉神 经痛的中药处方数据 (检索时间为建库至 2024 年 9 月 30 日), 运用 Excel 2021 软件进行性味归经和频次统计, 采用 R 4. 3. 3 软件 进行关联规则、聚类和相关性系数分析, 通过 Cytoscape 3. 8 软件构建中药核心复杂网络, 并提取密集中药集群。 结果: 共纳入 171 项专利, 涉及药物 609 味, 高频药物中前 4 位为川芎、甘草、全蝎和白芷。 药性以寒性为主, 其次为温性; 药味以苦味居首, 其次 为辛、甘味; 归经前 3 位为肝经、肺经和胃经。 常用对药为白芷-川芎、蜈蚣-全蝎、僵蚕-全蝎, 角药组合为白芷-全蝎-川芎、蜈蚣-川 芎-全蝎、僵蚕-全蝎-川芎等。 通过复杂聚类分析提取出核心药物组合 4 组, 并挖掘出潜在药物组合 2 个。 结论: 中药复方专利治 疗三叉神经痛以祛风止痛为基本治则, 本研究得出的用药规律及潜在药物组合, 可为指导临床用药及新药开发奠定基础。 [ABSTRACT FROM AUTHOR]
Datenbank: Academic Search Index
Beschreibung
Abstract:OBJECTIVE: To analyze the medication patterns of traditional Chinese medicine compound patents in the treatment of trigeminal neuralgia, so as to provide reference for the research and development of new prescriptions. METHODS: Prescription data of traditional Chinese medicine for trigeminal neuralgia in the national patent database were retrieved (search time was from database establishment to Sept. 30th, 2024), and Excel 2021 was used to perform statistics on flavors and frequency, R 4. 3. 3 software was used for the analysis of association rules, clustering, and correlation coefficients. The core complex network of traditional Chinese medicine was constructed by Cytoscape 3. 8, and the dense clusters of traditional Chinese medicine were extracted. RESULTS: A total of 171 patents were enrolled, including 609 flavors of medicines. The top 4 high-frequency medicines were Chuanxiong rhizoma, licorice, Buthus martensi, and Radix angelicae dahuricae. The medicinal properties were mainly cold, followed by warm. The medicinal flavors were bitter, followed by pungent and sweet. The top 3 meridians were liver meridian, lung meridian, and stomach meridian. The commonly used pairs of drugs were Radix angelicae dahuricae-Chuanxiong rhizoma, Scolopendra subspinipes mutilans-Buthus martensi, Bombyx Batryticatus-Buthus martensi, with the combinations including Radix angelicae dahuricae-Buthus martensi-Chuanxiong rhizoma, licorice, Scolopendra subspinipes mutilansChuanxiong rhizoma-Buthus martensi, Bombyx Batryticatus-Buthus martensi-Chuanxiong rhizoma. Four groups of core drug combinations were extracted by complex cluster analysis, and two potential drug combinations were identified. CONCLUSIONS: Traditional Chinese medicine compound patents in the treatment of trigeminal neuralgia are based on dispelling wind and relieving pain as the basic rule of treatment. The medication patterns and potential drug combinations obtained can lay a foundation for guiding clinical drug use and new drug development [ABSTRACT FROM AUTHOR]
ISSN:16722124
DOI:10.14009/j.issn.1672-2124.2025.04.001