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Regio‐ and Stereoselective β‐C(sp3)−H Activation/ Functionalization of Saturated Nitrogen Heterocycles, Amines and Amides.

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Titel: Regio‐ and Stereoselective β‐C(sp3)−H Activation/ Functionalization of Saturated Nitrogen Heterocycles, Amines and Amides.
Autoren: Yadav, Sanjay1,2 (AUTHOR), Murugesh, V.1,2 (AUTHOR) murugeshprasad@gmail.com, Suresh, Surisetti1,2 (AUTHOR) suresh.surisetti@yahoo.in
Quelle: Advanced Synthesis & Catalysis. Apr2025, Vol. 367 Issue 8, p1-48. 48p.
Schlagwörter: *TRANSITION metals, *TRANSFORMATION groups, *AMIDES, *HETEROCYCLIC compounds, *STEREOSELECTIVE reactions
Abstract: Regio‐ and stereoselective β‐C(sp3)−H bond functionalizations of saturated nitrogen heterocycles, amines/amides are challenging and have emerged as an important topic of research in the area of C(sp3)−H activation. Herein, we have summarized various β‐C(sp3)−H activation/functionalization methods; this review provides an overview of various trending approaches for β‐C(sp3)−H bond activation/functionalization of saturated nitrogen heterocycles, amines/amides. The regio‐ and stereoselective β‐C(sp3)−H bond activation methods are classified based on the reaction pathways. The literature methods including directing group or ligand‐assisted transformations, reactions proceeding through enamine intermediate, redox‐neutral methods and other trending methods including photoredox and transitional metal‐free methods are discussed with recent updates. [ABSTRACT FROM AUTHOR]
Datenbank: Academic Search Index
Beschreibung
Abstract:Regio‐ and stereoselective β‐C(sp3)−H bond functionalizations of saturated nitrogen heterocycles, amines/amides are challenging and have emerged as an important topic of research in the area of C(sp3)−H activation. Herein, we have summarized various β‐C(sp3)−H activation/functionalization methods; this review provides an overview of various trending approaches for β‐C(sp3)−H bond activation/functionalization of saturated nitrogen heterocycles, amines/amides. The regio‐ and stereoselective β‐C(sp3)−H bond activation methods are classified based on the reaction pathways. The literature methods including directing group or ligand‐assisted transformations, reactions proceeding through enamine intermediate, redox‐neutral methods and other trending methods including photoredox and transitional metal‐free methods are discussed with recent updates. [ABSTRACT FROM AUTHOR]
ISSN:16154150
DOI:10.1002/adsc.202401398