Comparative screening of tetra-chlorometallate anions in novel magnetic metallogeminisurfactant catalysts for advanced synthesis of an anti-tumor benzothiazol-based aminophosphonate drug (ACBTAP).
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| Titel: | Comparative screening of tetra-chlorometallate anions in novel magnetic metallogeminisurfactant catalysts for advanced synthesis of an anti-tumor benzothiazol-based aminophosphonate drug (ACBTAP). |
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| Autoren: | Tamaddon, Fatemeh1 (AUTHOR) ftamaddon@yazd.ac.ir, Tadayonfar, SeydEhsan1 (AUTHOR) ehsantadayonfar@stu.yazd.ac.ir |
| Quelle: | Journal of Molecular Liquids. Jun2019, Vol. 283, p51-57. 7p. |
| Schlagwörter: | *CATALYST synthesis, *CRITICAL micelle concentration, *MAGNETIC fluids, *MELTING points, *SURFACE tension, *SOLUBILIZATION, *ANIONIC surfactants |
| Abstract: | Due to the high surface activity and low critical micelle concentration (CMC) of metallogemini-surfactants (MGSs), in this work various magnetic MGSs (MMGS 1 s) were prepared by simple grinding of low-cost hydrated salts of Fe3+, Co2+, Mn2+ and Ni2+ with GS 1 synthesized by an improved solvent-free method. These new MMGS 1 s, which are complexes of 2FeCl 4 −, CoCl 4 2−, MnCl 4 2−, and NiCl 4 2− with GS 1 , were characterized by UV–Vis, FT-IR, and melting point (mp) analyses. So, the maximum UV–Vis absorption wavelength was due to the GS 1 2+·CoCl 4 2− and the minimum mp and pH were due to the GS 1 2+ ·2FeCl 4 − (MFeGS 1). The results of the catalytic activities of MMGS 1 s in solvent-free synthesis of anticancer O , O ′-diethyl-α-(benzothiazole-2-yl)amino(phenylmethyl) phosphonate (ACBTAP) revealed the superiority of MFeGS 1 , although catalysts were isolated as aqueous magnetic liquids (MLs) by addition of water. The aqueous MLs were further prepared in 0.01 and 0.1 molar concentration and analyzed by pH, surface tension (ᵞ), superconducting quantum interface device magnetometer (SQUID), and magnetic tests. Similar to GS 1 , all MMGS 1 s reduced the ᵞ of water by a half time ratio, while the magnetic activity of their aqueous MLs confirmed by magnetic drop-deviation and drop-movement over organic phase. The SQUID analysis of the aqueous MLs supported ferromagnetic properties for solution of MCoGS 1 , MNiGS 1 , and MMnGS 1 in water and paramagnetic properties for the aqueous solution of GS 1 2+·2FeCl 4 −. The as-prepared MLs are novel polar alternatives for organic solvents, water-treatment sorbents, and magnetic delivery of biomaterials. Unlabelled Image • Improved solvent-free synthesis of gemini-surfactant (GS 1) in 96% yield • MMGS 1 s gave by co-grinding of GS 1 and low-cost hydrated metal halides. • Upgraded preparation of magnetic metallogeminisurfactants (MMGS 1 s) • New aqueous magnetic liquids (MLs) by solubilizing of MMGS 1 s in water • The GS 1 2+·2FeCl 4 2− is a talented catalyst for synthesis of anticancer ACBTAP drug. [ABSTRACT FROM AUTHOR] |
| Datenbank: | Academic Search Index |
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Nájsť tento článok vo Web of Science | Abstract: | Due to the high surface activity and low critical micelle concentration (CMC) of metallogemini-surfactants (MGSs), in this work various magnetic MGSs (MMGS 1 s) were prepared by simple grinding of low-cost hydrated salts of Fe3+, Co2+, Mn2+ and Ni2+ with GS 1 synthesized by an improved solvent-free method. These new MMGS 1 s, which are complexes of 2FeCl 4 −, CoCl 4 2−, MnCl 4 2−, and NiCl 4 2− with GS 1 , were characterized by UV–Vis, FT-IR, and melting point (mp) analyses. So, the maximum UV–Vis absorption wavelength was due to the GS 1 2+·CoCl 4 2− and the minimum mp and pH were due to the GS 1 2+ ·2FeCl 4 − (MFeGS 1). The results of the catalytic activities of MMGS 1 s in solvent-free synthesis of anticancer O , O ′-diethyl-α-(benzothiazole-2-yl)amino(phenylmethyl) phosphonate (ACBTAP) revealed the superiority of MFeGS 1 , although catalysts were isolated as aqueous magnetic liquids (MLs) by addition of water. The aqueous MLs were further prepared in 0.01 and 0.1 molar concentration and analyzed by pH, surface tension (ᵞ), superconducting quantum interface device magnetometer (SQUID), and magnetic tests. Similar to GS 1 , all MMGS 1 s reduced the ᵞ of water by a half time ratio, while the magnetic activity of their aqueous MLs confirmed by magnetic drop-deviation and drop-movement over organic phase. The SQUID analysis of the aqueous MLs supported ferromagnetic properties for solution of MCoGS 1 , MNiGS 1 , and MMnGS 1 in water and paramagnetic properties for the aqueous solution of GS 1 2+·2FeCl 4 −. The as-prepared MLs are novel polar alternatives for organic solvents, water-treatment sorbents, and magnetic delivery of biomaterials. Unlabelled Image • Improved solvent-free synthesis of gemini-surfactant (GS 1) in 96% yield • MMGS 1 s gave by co-grinding of GS 1 and low-cost hydrated metal halides. • Upgraded preparation of magnetic metallogeminisurfactants (MMGS 1 s) • New aqueous magnetic liquids (MLs) by solubilizing of MMGS 1 s in water • The GS 1 2+·2FeCl 4 2− is a talented catalyst for synthesis of anticancer ACBTAP drug. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 01677322 |
| DOI: | 10.1016/j.molliq.2019.03.008 |