Prenatal Exposure to PM2:5 Oxidative Potential and Lung Function in Infants and Preschool- Age Children: A Prospective Study

BACKGROUND: Fine particulate matter (PM2:5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2:5 oxidative potential (OP) on lung function in infants and preschool children. OBJECTIVES: We estimated the associations of person...

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Veröffentlicht in:Environmental health perspectives Jg. 131; H. 1; S. 1 - 12
Hauptverfasser: Marsal, Anouk, Slama, Rémy, Lyon-Caen, Sarah, Borlaza, Lucille Joanna S, Jaffrezo, Jean-Luc, Boudier, Anne, Darfeuil, Sophie, Elazzouzi, Rhabira, Gioria, Yoann, Lepeule, Johanna, Chartier, Ryan, Pin, Isabelle, Quentin, Joane, Bayat, Sam, Uzu, Gaëlle, Siroux, Valérie
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Research Triangle Park National Institute of Environmental Health Sciences 01.01.2023
Schlagworte:
Acids
Ascorbic acid
Asthma
Children
Children & youth
Dithiothreitol
Exposure
Frequency dependence
Infants
Lungs
Mother-offspring interactions
Neonates
Nitrogen
Offspring
Outdoor air quality
Oxidative stress
Parameter estimation
Particulate emissions
Particulate matter
Pregnancy
Prenatal experience
Prenatal exposure
Preschool children
Respiratory diseases
Respiratory function
ISSN:1552-9924
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Zusammenfassung:BACKGROUND: Fine particulate matter (PM2:5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2:5 oxidative potential (OP) on lung function in infants and preschool children. OBJECTIVES: We estimated the associations of personal exposure to PM2:5 and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics. METHODS: We used data from 356 mother-child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout (N2MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM2:5 mass and OP with lung function parameters were estimated using multiple linear regressions. RESULTS: In neonates, an interquartile (IQR) increase in OPDTT v (0:89 nmol=min=m3) was associated with a decrease in functional residual capacity (FRC) measured by N2MBW [b= -2:26 mL; 95% confidence interval (CI): -4:68, 0.15]. Associations with PM2:5 showed similar patterns in comparison with OPDTT v but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs (Rrs7-19) from AOS tended to be associated with higher OPDTT v (b= 0:09 hPa ... s=L; 95% CI: -0:06, 0.24) and OPAA v (IQR = 1:14 nmol=min=m3; b= 0:12 hPa ... s=L; 95% CI: -0:04, 0.27) but not with PM2:5 (IQR = 6:9 lg=m3; b= 0:02 hPa ... s=L; 95% CI: -0:13, 0.16). Results for FRC and Rrs7-19 remained similar in OP models adjusted on PM2:5.
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ISSN:1552-9924
DOI:10.1289/EHP11155