Essential role of METTL3-mediated m 6 A modification in glioma stem-like cells maintenance and radioresistance

Despite advances in biology and therapeutic modalities, existence of highly tumorigenic glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible. N6-methyl adenosine (m A), one of the abundant mRNA modifications catalyzed by methyltransferase-like 3 and 14 (METTL3/14), influences various...

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Vydané v:	Oncogene Ročník 37; číslo 4; s. 522
Hlavní autori:	Visvanathan, A, Patil, V, Arora, A, Hegde, A S, Arivazhagan, A, Santosh, V, Somasundaram, K
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 25.01.2018
Predmet:	3' Untranslated Regions - genetics Adenosine - analogs & derivatives Adenosine - metabolism Animals Brain - cytology Brain - pathology Brain - surgery Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Brain Neoplasms - surgery Carcinogenesis - genetics Cell Dedifferentiation - genetics Cell Dedifferentiation - radiation effects Cell Line, Tumor Cell Proliferation - genetics DNA Repair - radiation effects ELAV-Like Protein 1 - metabolism Female Gene Expression Regulation, Neoplastic Glioblastoma - genetics Glioblastoma - pathology Glioblastoma - radiotherapy Glioblastoma - surgery Humans Methyltransferases - genetics Methyltransferases - metabolism Mice Mice, Nude Mutagenesis, Site-Directed Neoplastic Stem Cells - pathology Neoplastic Stem Cells - radiation effects Radiation Tolerance - genetics RNA, Messenger - metabolism SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Spheroids, Cellular - radiation effects Xenograft Model Antitumor Assays
ISSN:	1476-5594
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