Essential role of METTL3-mediated m 6 A modification in glioma stem-like cells maintenance and radioresistance

Despite advances in biology and therapeutic modalities, existence of highly tumorigenic glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible. N6-methyl adenosine (m A), one of the abundant mRNA modifications catalyzed by methyltransferase-like 3 and 14 (METTL3/14), influences various...

Full description

Saved in:

Bibliographic Details
Published in:	Oncogene Vol. 37; no. 4; p. 522
Main Authors:	Visvanathan, A, Patil, V, Arora, A, Hegde, A S, Arivazhagan, A, Santosh, V, Somasundaram, K
Format:	Journal Article
Language:	English
Published:	England 25.01.2018
Subjects:	3' Untranslated Regions - genetics Adenosine - analogs & derivatives Adenosine - metabolism Animals Brain - cytology Brain - pathology Brain - surgery Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Brain Neoplasms - surgery Carcinogenesis - genetics Cell Dedifferentiation - genetics Cell Dedifferentiation - radiation effects Cell Line, Tumor Cell Proliferation - genetics DNA Repair - radiation effects ELAV-Like Protein 1 - metabolism Female Gene Expression Regulation, Neoplastic Glioblastoma - genetics Glioblastoma - pathology Glioblastoma - radiotherapy Glioblastoma - surgery Humans Methyltransferases - genetics Methyltransferases - metabolism Mice Mice, Nude Mutagenesis, Site-Directed Neoplastic Stem Cells - pathology Neoplastic Stem Cells - radiation effects Radiation Tolerance - genetics RNA, Messenger - metabolism SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Spheroids, Cellular - radiation effects Xenograft Model Antitumor Assays
ISSN:	1476-5594
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!