Intracerebroventricular microinjection of the 5-HT 1F receptor agonist LY 344864 inhibits methamphetamine conditioned place preference reinstatement in rats
Relapse following a prolonged period of drug cessation is a key barrier in the treatment of methamphetamine (METH) addiction, for which pharmacological treatment exhibits little efficacy. Previous studies have suggested that this process involves alterations in levels of serotonin (5-HT) in the brai...
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| Vydané v: | Pharmacology, biochemistry and behavior Ročník 173; s. 27 |
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| Hlavní autori: | , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
01.10.2018
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| ISSN: | 1873-5177 |
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| Abstract | Relapse following a prolonged period of drug cessation is a key barrier in the treatment of methamphetamine (METH) addiction, for which pharmacological treatment exhibits little efficacy. Previous studies have suggested that this process involves alterations in levels of serotonin (5-HT) in the brain. Although the 5-HT
receptor has been implicated in the reward pathway, its physiological functions remain unknown. In the present study, we examined the effect of the 5-HT
agonist LY 344864 on the reinstatement of METH-seeking behavior in rats using a conditioned place preference (CPP) paradigm. The CPP paradigm was first used to determine the effective doses of LY and METH. Four groups were then conditioned with METH (5 mg/kg; i.p.), while the sham group received saline. METH-induced CPP was subsequently extinguished. On the 13th day of extinction, the rats received either METH (0, 1, or 2.5 mg/kg; i.p.) plus vehicle or priming METH plus LY (2 μg/5 μL; i.c.v.). On reinstatement day, preference scores were calculated as the difference in time spent in the drug-paired and vehicle-paired compartments. Rats conditioned with the lowest effective dose of METH (5 mg/kg) exhibited significant differences in pre- and post-testing preference scores. Preference scores were significantly higher in the saline + METH group than in the control group. Furthermore, preference scores were significantly higher in rats that had received priming METH treatment, and pre-treatment with LY significantly attenuated the reinstatement of METH-seeking behavior. These findings suggest that future studies should evaluate the therapeutic potential of 5-HT
agonists for preventing relapse in individuals with METH addiction. |
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| AbstractList | Relapse following a prolonged period of drug cessation is a key barrier in the treatment of methamphetamine (METH) addiction, for which pharmacological treatment exhibits little efficacy. Previous studies have suggested that this process involves alterations in levels of serotonin (5-HT) in the brain. Although the 5-HT
receptor has been implicated in the reward pathway, its physiological functions remain unknown. In the present study, we examined the effect of the 5-HT
agonist LY 344864 on the reinstatement of METH-seeking behavior in rats using a conditioned place preference (CPP) paradigm. The CPP paradigm was first used to determine the effective doses of LY and METH. Four groups were then conditioned with METH (5 mg/kg; i.p.), while the sham group received saline. METH-induced CPP was subsequently extinguished. On the 13th day of extinction, the rats received either METH (0, 1, or 2.5 mg/kg; i.p.) plus vehicle or priming METH plus LY (2 μg/5 μL; i.c.v.). On reinstatement day, preference scores were calculated as the difference in time spent in the drug-paired and vehicle-paired compartments. Rats conditioned with the lowest effective dose of METH (5 mg/kg) exhibited significant differences in pre- and post-testing preference scores. Preference scores were significantly higher in the saline + METH group than in the control group. Furthermore, preference scores were significantly higher in rats that had received priming METH treatment, and pre-treatment with LY significantly attenuated the reinstatement of METH-seeking behavior. These findings suggest that future studies should evaluate the therapeutic potential of 5-HT
agonists for preventing relapse in individuals with METH addiction. |
| Author | Sadeghian, Reihaneh Asl, Sara Soleimani Shahidi, Siamak Komaki, Alireza |
| Author_xml | – sequence: 1 givenname: Siamak surname: Shahidi fullname: Shahidi, Siamak organization: Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran – sequence: 2 givenname: Reihaneh surname: Sadeghian fullname: Sadeghian, Reihaneh email: re.sadeghian1414@gmail.com organization: Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: re.sadeghian1414@gmail.com – sequence: 3 givenname: Alireza surname: Komaki fullname: Komaki, Alireza organization: Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran – sequence: 4 givenname: Sara Soleimani surname: Asl fullname: Asl, Sara Soleimani organization: Anatomy Departments, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30077744$$D View this record in MEDLINE/PubMed |
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| Keywords | Relapse Conditioned place preference Serotonin receptor Methamphetamine |
| Language | English |
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| SubjectTerms | Amphetamine-Related Disorders - physiopathology Amphetamine-Related Disorders - psychology Animals Carbazoles - administration & dosage Carbazoles - pharmacology Central Nervous System Stimulants - pharmacology Conditioning, Classical - drug effects Dose-Response Relationship, Drug Fluorobenzenes - administration & dosage Fluorobenzenes - pharmacology Injections, Intraventricular Male Methamphetamine - pharmacology Rats Rats, Wistar Receptor, Serotonin, 5-HT1F Receptors, Serotonin - drug effects Recurrence Serotonin Receptor Agonists - pharmacology |
| Title | Intracerebroventricular microinjection of the 5-HT 1F receptor agonist LY 344864 inhibits methamphetamine conditioned place preference reinstatement in rats |
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