3466 Real-world diagnosis of chronic migraine in patients with cervical dystonia analyzed by botulinum neurotoxin treatment exposure: an epidemiologic perspective

BackgroundMigraine is a common comorbidity in patients with cervical dystonia (CD); however, the diagnosis of chronic migraine (CM) in patients with cervical dystonia (CD) is unknown.MethodsThis observational retrospective cohort study used longitudinal patient-level data from the Optum Market Clari...

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Published in:BMJ neurology open Vol. 7; no. Suppl 1; p. A20
Main Authors: Rodriguez, Ramon, Broner, Susan W, de, Grace, Rhyne, Christopher, Sadeghi Marjan, Xiaomeng Emma, Ukah Ahunna, Ifantides Kim Becker, Sarva Harini, Kidd, Juanita
Format: Journal Article
Language:English
Published: London BMJ Publishing Group LTD 01.10.2025
Subjects:
Comorbidity
Dystonia
Headaches
Medical coding
Migraine
ISSN:2632-6140
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Abstract BackgroundMigraine is a common comorbidity in patients with cervical dystonia (CD); however, the diagnosis of chronic migraine (CM) in patients with cervical dystonia (CD) is unknown.MethodsThis observational retrospective cohort study used longitudinal patient-level data from the Optum Market Clarity Database in the US. CD cohort includes patients ≥18y with ≥2CD diagnoses ≥30d apart during the study (January 2017 - September, 2021) and ≥180d of continuous health plan enrolment prior to cohort entry (first CD diagnosis coding). Cohort 1:CD+migraine/headache patients; cohort 2: CD+CM patients; cohorts 3 and 4: CD+CM BoNT treated and BoNT-untreated patients, respectively. Assessments include diagnosis, demographics and clinical characteristics of migraine/headache in the CD cohort.ResultsOf 81,884 CD patients, 36.1% had migraine/headache (cohort 1, n=29,533), 12.6% had concurrent CM (cohort 2, n=10,284). There were more CD+CM patients in cohort 4(BoNT-untreated) compared to cohort 3 (BoNT-treated) (57.4% vs 42.6%). Common comorbidities were comparable across cohorts 1–4 (neck pain, range: 63.6% - 78.8%; psychiatric conditions, range: 37.5% - 43.3%). The proportion of patients with psychiatric conditions in the CD+CM cohort was greater compared to the overall CD cohort (42.9% vs 28.1%). CD+CM patients treated with BoNT for both CD and CM diagnoses were higher (24.6%) than those treated for CD or CM individually (19.6% and 16.6%)ConclusionThis study provides evidence that CM is a common comorbidity in CD patients and therefore underscores the importance of diagnosis and selection of appropriate treatment options for managing these disease states.
AbstractList BackgroundMigraine is a common comorbidity in patients with cervical dystonia (CD); however, the diagnosis of chronic migraine (CM) in patients with cervical dystonia (CD) is unknown.MethodsThis observational retrospective cohort study used longitudinal patient-level data from the Optum Market Clarity Database in the US. CD cohort includes patients ≥18y with ≥2CD diagnoses ≥30d apart during the study (January 2017 - September, 2021) and ≥180d of continuous health plan enrolment prior to cohort entry (first CD diagnosis coding). Cohort 1:CD+migraine/headache patients; cohort 2: CD+CM patients; cohorts 3 and 4: CD+CM BoNT treated and BoNT-untreated patients, respectively. Assessments include diagnosis, demographics and clinical characteristics of migraine/headache in the CD cohort.ResultsOf 81,884 CD patients, 36.1% had migraine/headache (cohort 1, n=29,533), 12.6% had concurrent CM (cohort 2, n=10,284). There were more CD+CM patients in cohort 4(BoNT-untreated) compared to cohort 3 (BoNT-treated) (57.4% vs 42.6%). Common comorbidities were comparable across cohorts 1–4 (neck pain, range: 63.6% - 78.8%; psychiatric conditions, range: 37.5% - 43.3%). The proportion of patients with psychiatric conditions in the CD+CM cohort was greater compared to the overall CD cohort (42.9% vs 28.1%). CD+CM patients treated with BoNT for both CD and CM diagnoses were higher (24.6%) than those treated for CD or CM individually (19.6% and 16.6%)ConclusionThis study provides evidence that CM is a common comorbidity in CD patients and therefore underscores the importance of diagnosis and selection of appropriate treatment options for managing these disease states.
Author Ifantides Kim Becker
Kidd, Juanita
Broner, Susan W
Xiaomeng Emma
Sadeghi Marjan
Ukah Ahunna
Rhyne, Christopher
Rodriguez, Ramon
de, Grace
Sarva Harini
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Snippet BackgroundMigraine is a common comorbidity in patients with cervical dystonia (CD); however, the diagnosis of chronic migraine (CM) in patients with cervical...
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SubjectTerms Comorbidity
Dystonia
Headaches
Medical coding
Migraine
Title 3466 Real-world diagnosis of chronic migraine in patients with cervical dystonia analyzed by botulinum neurotoxin treatment exposure: an epidemiologic perspective
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