Clustering of Pattern Recognition Receptors for Fungal Detection e1003873
[...]it has been reported that DC-SIGN synergizes TLR signaling through RAF1, a serine/threonine kinase, which induces phosphorylation of the p65 subunit of NFκB, followed by prolonged and enhanced transcription of Il10 by NFκB activation [14]. [...]OPN-deficient immunocompromised mice are extreme...
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| Vydané v: | PLoS pathogens Ročník 10; číslo 2 |
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| Hlavní autori: | , |
| Médium: | Journal Article |
| Jazyk: | English |
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Public Library of Science
01.02.2014
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| Abstract | [...]it has been reported that DC-SIGN synergizes TLR signaling through RAF1, a serine/threonine kinase, which induces phosphorylation of the p65 subunit of NFκB, followed by prolonged and enhanced transcription of Il10 by NFκB activation [14]. [...]OPN-deficient immunocompromised mice are extremely susceptible to opportunistic infection by Pneumocystis [10]. iOPN is known to co-localize with actin and induces cytoskeletal rearrangement [18], [19]. |
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| AbstractList | [...]it has been reported that DC-SIGN synergizes TLR signaling through RAF1, a serine/threonine kinase, which induces phosphorylation of the p65 subunit of NFκB, followed by prolonged and enhanced transcription of Il10 by NFκB activation [14]. [...]OPN-deficient immunocompromised mice are extremely susceptible to opportunistic infection by Pneumocystis [10]. iOPN is known to co-localize with actin and induces cytoskeletal rearrangement [18], [19]. |
| Author | Inoue, Makoto Shinohara, Mari L |
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| Copyright | 2014 Inoue, Shinohara. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Inoue M, Shinohara ML (2014) Clustering of Pattern Recognition Receptors for Fungal Detection. PLoS Pathog 10(2): e1003873. doi:10.1371/journal.ppat.1003873 |
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| DOI | 10.1371/journal.ppat.1003873 |
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| SubjectTerms | Chemokines Cytokines Fungal infections Fungi Immune system Kinases Ligands Lipids Lymphocytes Lymphoma Pattern recognition Phosphorylation Proteins |
| Subtitle | e1003873 |
| Title | Clustering of Pattern Recognition Receptors for Fungal Detection |
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