More severe hypercoagulable state in acute COVID-19 pneumonia as compared to other pneumonia

To conduct a comprehensive evaluation of coagulation profiles - via traditional and whole blood thromboelastometry tests - in COVID-19 positive vs. COVID-19 negative patients admitted to medical wards for acute pneumonia. We enrolled all consecutive patients admitted to Internal Medicine wards of Pa...

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Vydáno v:Mayo Clinic proceedings. Innovations, quality & outcomes
Hlavní autoři: Spiezia, Luca, Campello, Elena, Cola, Marco, Poletto, Francesco, Cerruti, Lorenzo, Poretto, Anna, Simion, Chiara, Cattelan, Annamaria, Vettor, Roberto, Simioni, Paolo
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands 12.04.2021
Témata:
CFT, clot formation time
aPTT, activated partial thromboplastin time
listPT, prothrombin time
CT, clotting time
MCF, maximum clot firmness
ISSN:2542-4548, 2542-4548
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Shrnutí:To conduct a comprehensive evaluation of coagulation profiles - via traditional and whole blood thromboelastometry tests - in COVID-19 positive vs. COVID-19 negative patients admitted to medical wards for acute pneumonia. We enrolled all consecutive patients admitted to Internal Medicine wards of Padova University Hospital between 7 March and 30 April 2020 for COVID-19-related pneumonia (cases) vs. non-COVID-19 pneumonia (controls). A group of healthy subjects acted as baseline for thromboelastometry parameters. Fifty-six cases (mean age 64±15 yrs, M/F 37/19) and 56 controls (mean age 76±11 yrs, M/F 35/21) were enrolled. Cases and controls showed markedly hypercoagulable thromboelastometry profiles vs. healthy subjects, mainly characterized by a significantly shorter propagation phase of coagulation (Clot Formation Time, CFT) and significantly increased maximum clot firmness (MCF) (p <0.001 in all comparisons). COVID-19 patients with pneumonia had significantly shorter CFT and higher MCF (p <0.01 and <0.05, respectively in all comparisons) vs. controls. Patients admitted to internal medicine wards for COVID-19 pneumonia presented a markedly prothrombotic state, which seems peculiar to COVID-19 rather than pneumonia itself.
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ISSN:2542-4548
2542-4548
DOI:10.1016/j.mayocpiqo.2020.08.014