Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women e1000118

While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide associa...

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Vydáno v:PLoS genetics Ročník 4; číslo 7
Hlavní autoři: Paré, Guillaume, Chasman, Daniel I, Kellogg, Mark, Zee, Robert YL, Rifai, Nader, Badola, Sunita, Miletich, Joseph P, Ridker, Paul M
Médium: Journal Article
Jazyk:angličtina
Vydáno: San Francisco Public Library of Science 01.07.2008
Témata:
Blood
Cancer
Cardiovascular disease
Charitable foundations
Genes
Genomes
Malaria
Mortality
Plasma
Proteins
Stroke
Womens health
ISSN:1553-7390, 1553-7404
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Shrnutí:While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5×10-8), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1×10-29) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.
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ISSN:1553-7390
1553-7404
DOI:10.1371/journal.pgen.1000118