Research on predicting the risk of mild cognitive impairment in the elderly based on the joint model

To construct and compare the dynamic prediction models of the risk of mild cognitive impairment (MCI) in the elderly based on six different cognitive function scales. Based on longitudinal data from the Alzheimer's Disease Neuroimaging Initiative from 2005 to 2020, Mini-mental state examination...

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Bibliographic Details
Published in:Zhōnghuá liúxíngbìng zázhì Vol. 43; no. 2; p. 269
Main Authors: Xu, J, Yuan, M Q, Fang, Y
Format: Journal Article
Language:Chinese
Published: China 10.02.2022
Subjects:
Aged
Alzheimer Disease - diagnosis
Alzheimer Disease - psychology
Cognition
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - epidemiology
Humans
Middle Aged
Neuropsychological Tests
Risk Factors
ISSN:0254-6450
Online Access:Get more information
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Summary:To construct and compare the dynamic prediction models of the risk of mild cognitive impairment (MCI) in the elderly based on six different cognitive function scales. Based on longitudinal data from the Alzheimer's Disease Neuroimaging Initiative from 2005 to 2020, Mini-mental state examination (MMSE), functional activities questionnaire (FAQ), Alzheimer's disease assessment scale-cognitive (ADAS-Cog) 11, ADAS-Cog13, ADAS delayed word recall (ADASQ4), and Rey auditory verbal learning test (RAVLT)_immediate were used as longitudinal cognitive function evaluation indicators to assess the longitudinal changes in cognitive function. The joint model was used to analyze association between indicators variation trajectory and survival outcome MCI, and construct the risk prediction model of MCI in the elderly, the linear mixed model was constructed the longitudinal sub-model which described the evolution of a repeated measure over time, a proportional hazards model was constructed the survival sub-model, and the two
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ISSN:0254-6450
DOI:10.3760/cma.j.cn112338-20210620-00484