EXTRACELLULAR VESICLES FROM BLOOD PLASMA STUDIED BY LOW VOLTAGE SCANNING ELECTRON MICROSCOPY

Extracellular vesicles are subspherical membranous structures secreted by cells and enriched with different types of biological molecules. The number and the molecular content of these structures depend on pathological conditions and the physiological state of the organism. Extracellular vesicles pl...

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Vydáno v:T͡S︡itologii͡a Ročník 59; číslo 3; s. 169
Hlavní autoři: Kondratov, K A, Petrova, T A, Mikhailovskii, V Yu, Ivanova, A N, Kostareva, A A, Fedorov, A V
Médium: Journal Article
Jazyk:angličtina
ruština
Vydáno: Russia (Federation) 2017
Témata:
Animals
Cell-Derived Microparticles - metabolism
Cell-Derived Microparticles - ultrastructure
Extracellular Vesicles - metabolism
Extracellular Vesicles - ultrastructure
Humans
Male
Microscopy, Electron, Scanning
Plasma
Rats
Rats, Wistar
ISSN:0041-3771
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Shrnutí:Extracellular vesicles are subspherical membranous structures secreted by cells and enriched with different types of biological molecules. The number and the molecular content of these structures depend on pathological conditions and the physiological state of the organism. Extracellular vesicles play an important role in intercellular communication and represent potential disease biomarkers. However, mechanisms of formation, functions and morphological characteristics of extracellular vesicles are still studied insufficiently. Low voltage scanning electron microscopy is a promising method to investigate extracellular vesicles, since it does not require conductive coating and therefore enables a high-resolution visualization of morphological details of nanosized objects. This paper presents the results of low voltage scanning electron microscopy study of morphology and size of objects from blood plasma fractions.
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ISSN:0041-3771