ANALGESIC ACTIVITY OF SOME NEW DECAHYDROQUINOLINE DERIVATIVES.
The work was aimed at assessing in vivo the analgesic properties of ten decahydroquinoline derivatives (pharmacologically active substances, PAS) and deter- mining the role of opioid receptors in mechanism of their action. Among the derivatives studied, pronounced analgesic properties at a dose of 1...
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| Vydané v: | Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Ročník 79; číslo 11; s. 7 |
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| Hlavní autori: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | Russian |
| Vydavateľské údaje: |
Russia (Federation)
2016
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| ISSN: | 0869-2092 |
| On-line prístup: | Zistit podrobnosti o prístupe |
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| Shrnutí: | The work was aimed at assessing in vivo the analgesic properties of ten decahydroquinoline derivatives (pharmacologically active substances, PAS) and deter- mining the role of opioid receptors in mechanism of their action. Among the derivatives studied, pronounced analgesic properties at a dose of 1/4 LD50 was ob- served for two compounds (PAS-70 and PAS-71), while four compounds (PAS-66, PAS-69, PAS-74, PAS-76) produced weak and short anesthetic effects. PAS-70 and PAS-71 showed analgesic action even in a dose of 1/8 LD50. The maximum effect of PAS-70 and PAS-71 was developed within 20 - 60 min after administration and lasted for two hours (PAS-70 in a dose of 1/4 LD50, PAS-71 in doses of 1/4 and 1/8 LD50). The analgesic effect of PAS-70 (at 1/4 LD5,) and PAS-71 (at 1/4 and 1/8 LD50) significantly exceeds that of reference drugs metamizol (1/4 LD5) and ketorolac (1/4 LD50). The mechanism of drug action is not related to opioid receptors. |
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| Bibliografia: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0869-2092 |