Respiratory pathogen spectrum in pulmonary exacerbation of bronchiectasis in adults and its association with disease severity

To determine the pattern of respiratory pathogens at bronchiectasis exacerbation and its associations with disease severity. A total of 119 steady-state bronchiectasis patients [42 males, 77 females, age range 19 to 74 years, mean age (45±14)years], diagnosed by a compatible history combined with ev...

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Published in:Zhonghua jiehe he huxi zazhi Vol. 42; no. 4; p. 254
Main Authors: Gao, Y H, Guan, W J, Zhu, Y N, Chen, R C, Zhang, G J
Format: Journal Article
Language:Chinese
Published: China 12.04.2019
Subjects:
Adult
Aged
Bronchiectasis - blood
Bronchiectasis - microbiology
Bronchiectasis - physiopathology
Bronchiectasis - virology
China - epidemiology
Female
Haemophilus influenzae
Humans
Inflammation Mediators - blood
Lung - physiopathology
Lung - virology
Male
Middle Aged
Prospective Studies
Respiratory Tract Infections - diagnosis
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - microbiology
Respiratory Tract Infections - virology
Spirometry - methods
Sputum - microbiology
Sputum - virology
Tomography, X-Ray Computed
Young Adult
China
Bacteria
Viruses
Bronchiectasis
Acute exacerbation
ISSN:1001-0939
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Summary:To determine the pattern of respiratory pathogens at bronchiectasis exacerbation and its associations with disease severity. A total of 119 steady-state bronchiectasis patients [42 males, 77 females, age range 19 to 74 years, mean age (45±14)years], diagnosed by a compatible history combined with evidence of bronchial dilatation on high-resolution computed tomography (HRCT), were recruited prospectively from out-patient clinics in the First Affiliated Hospital of Guangzhou Medical University between September 2012 and March 2013. A comprehensive history taking, radiologic appearance, spirometry, sputum bacterial culture and 16 respiratory viruses in nasopharyngeal swabs and sputum samples by PCR assays were collected at steady-state bronchiectasis. All bronchiectasis patients were followed up one year and assessed for bacteriology, virology and systemic inflammatory indices [including white blood cell, C-reactive protein (CRP), interleukin-6, 8 and tumor necrosis factor-α] during bronchiectasis exacerbation.
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ISSN:1001-0939
DOI:10.3760/cma.j.issn.1001-0939.2019.04.002