Characteristics of airway microbiome co-occurrence network in patients with type 2 and non-type 2 asthma

To study the characteristics of the airway microbiome co-occurrence network in patients with type 2 and non-type 2 asthma. In a prospective study based on a cohort of asthma patients, respiratory induced sputum samples were collected from 55 asthma patients [25 males and 30 females, with a median ag...

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Bibliographic Details
Published in:Zhonghua jiehe he huxi zazhi Vol. 47; no. 12; p. 1121
Main Authors: Wang, W, Wang, F R, Guo, Y, Zhang, H B, Jiang, F F
Format: Journal Article
Language:Chinese
Published: China 12.12.2024
Subjects:
Adult
Asthma - metabolism
Asthma - microbiology
Breath Tests
Case-Control Studies
Female
Humans
Male
Microbiota
Middle Aged
Nitric Oxide - metabolism
Prospective Studies
Respiratory System - metabolism
Respiratory System - microbiology
Sputum - microbiology
ISSN:1001-0939
Online Access:Get more information
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Summary:To study the characteristics of the airway microbiome co-occurrence network in patients with type 2 and non-type 2 asthma. In a prospective study based on a cohort of asthma patients, respiratory induced sputum samples were collected from 55 asthma patients [25 males and 30 females, with a median age of 47.7 years (age range 34.3-63.0 years)] admitted to the Department of Respiratory and Critical Care, Beijing Chaoyang Hospital, Capital Medical University and 12 healthy controls from the Physical Examination Centre of Beijing Chaoyang Hospital, Capital Medical University, from May 2021 to May 2022. According to the level of exhaled breath nitric oxide (FeNO), the asthma patients were divided into 22 cases in the high FeNO group (FeNO≥40 ppb, , type 2 asthma group) and 33 cases in the low FeNO group (FeNO<40 ppb, i.e., non-type 2 asthma group). All induced sputum samples were subjected to second-generation macrogenomic sequencing and bioinformatic analyses of microbial community diversity, compositional charac
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ISSN:1001-0939
DOI:10.3760/cma.j.cn112147-20241015-00611